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Medical Oncology
Erschienen in: Medical Oncology 6/2020

01.06.2020 | Original Paper

Ablation, consolidation and radiotherapy for the management of metastatic lesions of the spine: impact on the quality of life in a mid-term clinical and diagnostic follow-up in a pilot study

verfasst von: Francesco Arrigoni, Camilla de Cataldo, Federico Bruno, Pierpaolo Palumbo, Luigi Zugaro, Mario Di Staso, Giovanni Luca Gravina, Antonio Barile, Carlo Masciocchi

Erschienen in: Medical Oncology | Ausgabe 6/2020

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Abstract

Bone metastasis in the spine are lesions that are very challenging to manage because of pain, possible respiratory and neurological complications due to the closeness with the spinal cord. In fact, a fracture of a vertebra weakened by a pathological tissue can occur. In this paper, an experience of a single center in treating bone metastasis in the vertebral soma is reported (both fractured than with an increased risk of fracture) with a combined procedure of ablation, vertebroplasty and radiotherapy. This combined strategy aims to obtain an increased ability to treat the pathological tissue (ablation and radiotherapy) and a stabilization of the osteolytic lesion (vertebroplasty). We evaluated the outcome of this procedure in 12 lesions (in 11 patients) with a follow-up (from 6 to 48 months) with clinical and imaging data. Patients showed an immediate, rapid and persistent regression of the symptomatology in all lesions except two. Moreover, a stability of the disease in the bone segment treatment was reached. Even if this is a pilot study for the number of patients and the follow-up, we believe that this approach could be promising as these early results are. In specific clinical conditions and selected patients, this study seems to be possible to perform a curative approach.
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Metadaten
Titel
Ablation, consolidation and radiotherapy for the management of metastatic lesions of the spine: impact on the quality of life in a mid-term clinical and diagnostic follow-up in a pilot study
verfasst von
Francesco Arrigoni
Camilla de Cataldo
Federico Bruno
Pierpaolo Palumbo
Luigi Zugaro
Mario Di Staso
Giovanni Luca Gravina
Antonio Barile
Carlo Masciocchi
Publikationsdatum
01.06.2020
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 6/2020
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-020-01378-6

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