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European Journal of Nuclear Medicine and Molecular Imaging

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01.04.2010 | Original Article

Abnormal response to mental stress in patients with Takotsubo cardiomyopathy detected by gated single photon emission computed tomography

verfasst von: Roberto Sciagrà, Guido Parodi, Stefano Del Pace, Sabrina Genovese, Linda Zampini, Benedetta Bellandi, Gian Franco Gensini, Alberto Pupi, David Antoniucci

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2010

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Abstract

Purpose

Persistent abnormalities are usually not detected in patients with Takotsubo cardiomyopathy (TTC). Since sympathetically mediated myocardial damage has been proposed as a causative mechanism of TTC, we explored whether mental stress could evoke abnormalities in these patients.

Methods

One month after an acute event, 22 patients fulfilling all TTC diagnostic criteria and 11 controls underwent resting and mental stress gated single photon emission computed tomography (SPECT). Perfusion, wall motion, transient ischaemic dilation (TID) and left ventricular (LV) ejection fraction (EF) were evaluated.

Results

None of the controls showed stress-induced abnormalities. Mental stress evoked regional changes (perfusion defects and/or wall motion abnormality) in 16 TTC subjects and global abnormalities (LVEF fall >5% and/or TID >1.10) in 13; 3 had a completely negative response. TID, delta LVEF and delta wall motion score were significantly different in TTC vs control patients: 1.08 ± 0.20 vs 0.95 ± 0.11 (p < 0.05), −1.7 ± 6% vs 4 ± 5% (p < 0.02) and 2.5 (0, 4.25) vs 0 (0, 0) (p < 0.002), respectively.

Conclusion

Mental stress may evoke regional and/or global abnormalities in most TTC patients. The abnormal response to mental stress supports the role of sympathetic stimulation in TTC. Mental stress could thus be helpful for TTC evaluation.

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Titel: Abnormal response to mental stress in patients with Takotsubo cardiomyopathy detected by gated single photon emission computed tomography
verfasst von: Roberto Sciagrà
Guido Parodi
Stefano Del Pace
Sabrina Genovese
Linda Zampini
Benedetta Bellandi
Gian Franco Gensini
Alberto Pupi
David Antoniucci
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2010
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1362-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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