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Journal of Natural Medicines

Erschienen in:

01.07.2011 | Note

Acoschimperoside P, 2′-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

verfasst von: Yusnita Rifai, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Erschienen in: Journal of Natural Medicines | Ausgabe 3-4/2011

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Abstract

Complete ¹H and ¹³C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

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Titel: Acoschimperoside P, 2′-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra
verfasst von: Yusnita Rifai
Midori A. Arai
Takashi Koyano
Thaworn Kowithayakorn
Masami Ishibashi
Publikationsdatum: 01.07.2011
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3-4/2011
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0530-1

Springer Medizin

Abstract

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