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European Journal of Pediatrics
Erschienen in: European Journal of Pediatrics 6/2004

01.06.2004 | Review

Advances in Kawasaki disease

verfasst von: Stanford T. Shulman, Anne H. Rowley

Erschienen in: European Journal of Pediatrics | Ausgabe 6/2004

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Abstract

Recent studies have increased our understanding of the etiopathogenesis of Kawasaki disease (KD). The inflammatory infiltrate in KD coronary artery aneurysms has been shown to consist of CD8 T lymphocytes, macrophages, and IgA plasma cells, consistent with an immune response to an intracellular pathogen with a mucosal portal of entry. The identification of an oligoclonal IgA response in the vascular wall and the detection of a KD-associated antigen in inflamed KD tissues using a synthetic antibody derived from KD oligoclonal IgA antibodies have provided new approaches to identification of the etiologic agent. Highly effective therapy has evolved for KD, even in the absence of identification of the etiologic agent. The existence of incomplete KD cases remains a significant diagnostic dilemma for the clinician. Conclusion: the development of a diagnostic test, more specific therapy, and ultimate prevention of this potentially fatal illness of childhood are dependent upon continued advances in determining the etiopathogenesis of this fascinating disorder.
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Metadaten
Titel
Advances in Kawasaki disease
verfasst von
Stanford T. Shulman
Anne H. Rowley
Publikationsdatum
01.06.2004
Verlag
Springer-Verlag
Erschienen in
European Journal of Pediatrics / Ausgabe 6/2004
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-004-1431-z

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