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Supportive Care in Cancer
Erschienen in: Supportive Care in Cancer 7/2018

18.04.2018 | Review Article

Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis

verfasst von: Alexander Bourdon, Scott A. Grandy, Melanie R. Keats

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2018

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Abstract

Purpose

The main purpose of this review was to synthesize evidence from existing childhood cancer survivor studies that report the effect of aerobic exercise on cardiopulmonary fitness (a marker of cardiovascular health), in survivors that were currently receiving or had been treated with a cardiotoxic agent.

Methods

Studies were identified for this review by searching both electronic databases of peer-reviewed articles, as well as various sources of gray literature. Risk of bias was qualitatively assessed in these studies using the domains outlined in the Cochrane Handbook for Systematic Reviews of Interventions. Data was analyzed quantitatively using random-effects meta-analyses and subgroup analyses in RevMan Software.

Results

Meta-analysis of pooled evidence from the nine included studies suggests that aerobic exercise has a statistically and clinically significant positive effect on cardiopulmonary fitness (effect estimate = 6.92%, p value = 0.02). Findings from subgroup analyses of clinical characteristics and exercise parameters were not significant.

Conclusions

The findings from this review, although not directly demonstrating a cardioprotective effect, are a preliminary step towards establishing the putative cardioprotective effect of aerobic exercise against the direct cardiotoxic impact of cancer treatments. The significant positive effect estimate in favor of aerobic exercise is a small but important advancement towards the standardization of aerobic exercise in childhood cancer survivors. Further studies are necessary.
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Literatur
1.
Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2017) SEER Cancer statistics review, 1975–2014, National Cancer Institute. Bethesda, MD https://​seer.​cancer.​gov/​csr/​1975_​2014/​
2.
Smith M, Hare ML (2004) An overview of progress in childhood cancer survival. J Pediatr Oncol Nurs 21:160–164CrossRefPubMed
3.
4.
Mertens AC, Liu Q, Neglia LP, Wasilewski K, Leisenring W, Armstrong GT, Robison LL, Yasui Y (2008) Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. 100:1368–1379
5.
Schlitt A, Jordan K, Vordermark D, Schwamborn J, Langer T, Thomssen C (2014) Cardiotoxicity and oncological treatments. Dtsch Arztebl Int 111:161–168PubMedPubMedCentral
6.
Adao R, de Keulenaer G, Leite-Moreira A, Bras-Silva C (2013) Cardiotoxicity associated with cancer therapy: pathophysiology and prevention strategies. Rev Port Cardiol 32:395–409PubMedCrossRef
7.
Aleman BM, van den Belt-Dusebout AW, De Bruin ML, van’t Veer MB, Baaijens MH, de Boer JP, Hart AA, Klokman WJ, Kuenen MA, Ouwens GM, Bartelink H, van Leeuwen FE (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109:1878–1886CrossRefPubMed
8.
Bovelli D, Plataniotis G, Roila F, ESMO Guidelines Working Group (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann Oncol 21(Suppl 5):v277–v282CrossRefPubMed
9.
Jones RL, Swanton C, Ewer MS (2006) Anthracycline cardiotoxicity. Expert Opin Drug Saf 5:791–809CrossRefPubMed
10.
Chen MH, Colan SD, Diller L (2011) Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 108:619–628CrossRefPubMed
11.
Harake D, Franco VI, Henkel JM, Miller TL, Lipshultz SE (2012) Cardiotoxicity in childhood cancer survivors: strategies for prevention and management. Futur Cardiol 8:647–670CrossRef
12.
van Laar M, Feltbower RG, Gale CP, Bowen DT, Oliver SE, Glaser A (2014) Cardiovascular sequelae in long-term survivors of young peoples’ cancer: a linked cohort study. Br J Cancer 110:1338–1341CrossRefPubMedPubMedCentral
13.
Franco VI, Lipshultz SE (2015) Cardiac complications in childhood cancer survivors treated with anthracyclines. Cardiol Young 25(Suppl 2):107–116CrossRefPubMed
14.
15.
Hutchins KK, Siddeek H, Franco VI, Lipshultz SE (2017) Prevention of cardiotoxicity among survivors of childhood cancer. Br J Clin Pharmacol 83:455–465CrossRefPubMed
16.
Hodgson DC (2011) Late effects in the era of modern therapy for Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2011:323–329
17.
Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561–578CrossRefPubMed
18.
Brenner DJ, Shuryak I, Jozsef G, Dewyngaert KJ, Formenti SC (2014) Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med 174:158–160CrossRefPubMed
19.
Sieswerda E, van Dalen EC, Postma A, Cheuk DK, Caron HN, Kremer LC (2011) Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Cochrane Database Syst Rev (9):CD008011. https://​doi.​org/​10.​1002/​14651858.​CD008011.​pub2.
20.
Hamer M, Ingle L, Carroll S, Stamatakis E (2012) Physical activity and cardiovascular mortality risk: possible protective mechanisms? Med Sci Sports Exerc 44:84–88CrossRefPubMed
21.
Hopper I, Billah B, Skiba M, Krum H (2011) Prevention of diabetes and reduction in major cardiovascular events in studies of subjects with prediabetes: meta-analysis of randomised controlled clinical trials. Eur J Cardiovasc Prev Rehabil 18:813–823CrossRefPubMed
22.
23.
Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML (1996) Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94:857–862CrossRefPubMed
24.
25.
Riner WF, Sellhorst SH (2013) Physical activity and exercise in children with chronic health conditions. 2:12–20
26.
Kelly AK (2011) Physical activity prescription for childhood cancer survivors. Curr Sports Med Rep 10:352–359CrossRefPubMed
27.
Baumann FT, Bloch W, Beulertz J (2013) Clinical exercise interventions in pediatric oncology: a systematic review. Pediatr Res 74:366–374CrossRefPubMed
28.
Miller TL, Horgan S, Lipshultz SE (2005) Exercise rehabilitation of pediatric patients with cardiovascular disease. 20:27–37
29.
Sasso JP, Eves ND, Christensen JF, Koelwyn GJ, Scott J, Jones LW (2015) A framework for prescription in exercise-oncology research. J Cachexia Sarcopenia Muscle 6:115–124CrossRefPubMedPubMedCentral
30.
van Brussel M, Takken T, Lucia A, van der Net J, Helders PJ (2005) Is physical fitness decreased in survivors of childhood leukemia? A systematic review. Leukemia 19:13–17CrossRefPubMed
31.
Matthys D, Verhaaren H, Benoit Y, Laureys G, De Naeyer A, Craen M (1993) Gender difference in aerobic capacity in adolescents after cure from malignant disease in childhood. Acta Paediatr 82:459–462CrossRefPubMed
32.
Chamorro-Vina C, Keats MR, Culos-Reed NS (2015) Pediatric Oncology Exercise Manual
33.
Chen JJ, Wu PT, Middlekauff HR, Nguyen KL (2017) Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. Am J Physiol Heart Circ Physiol 312:H213–H222CrossRefPubMed
34.
Jones LW, Liang Y, Pituskin EN, Battaglini CL, Scott JM, Hornsby WE, Haykowsky M (2011) Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis. Oncologist 16:112–120CrossRefPubMedPubMedCentral
35.
Beaudry R (2015) Effect of supervised exercise on aerobic capacity in cancer survivors: adherence and workload predict variance in effect. 3:43
36.
Liu RD, Chinapaw MJ, Huijgens PC, van Mechelen W (2009) Physical exercise interventions in haematological cancer patients, feasible to conduct but effectiveness to be established: a systematic literature review. Cancer Treat Rev 35:185–192CrossRefPubMed
37.
Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ (2016) Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev 3:CD008796PubMed
38.
Moug SJ, Bryce A, Mutrie N, Anderson AS (2017) Lifestyle interventions are feasible in patients with colorectal cancer with potential short-term health benefits: a systematic review. Int J Color Dis 32:765–775CrossRef
39.
Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP, HF-ACTION Investigators (2009) Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301:1451–1459CrossRefPubMedPubMedCentral
40.
Tukenova M, Guibout C, Oberlin O, Doyon F, Mousannif A, Haddy N, Guerin S, Pacquement H, Aouba A, Hawkins M, Winter D, Bourhis J, Lefkopoulos D, Diallo I, de Vathaire F (2010) Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol 28:1308–1315CrossRefPubMed
41.
Pescatello LS (2014) Interpretation of clinical exercise test results. In: Anonymous ACSM’s guidelines for exercise testing and prescription, 9th ed. edn. Wolters Kluwer/Lippincott Williams & Wilkins Health., Philadelphia, pp 241–266
42.
Hutton B, Moher D, Cameron C (2015) The PRISMA extension statement. Ann Intern Med 163:566–567CrossRefPubMed
43.
Higgins JPT, Altman DG, Sterne JAC (2011) Assessing risk of bias in included studies. In: Higgins JPT, Green S (eds) Cochrane handbook for systematic reviews of interventions. 5.1.0 [updated march 2011] The Cochrane Collaboration
44.
The Cochrane Collaboration (2014) Review Manager (RevMan)
45.
46.
Schunemann H, Brozek J, Guyatt G, Oxman A (2013) GRADE Handbook
47.
Dubnov-Raz G, Azar M, Reuveny R, Katz U, Weintraub M, Constantini NW (2015) Changes in fitness are associated with changes in body composition and bone health in children after cancer. Acta Paediatr 104:1055–1061CrossRefPubMed
48.
Shore S (1998) The effect of a moderate aerobic training program on T.B. and natural killer cell function in normal adults, normal children, and children with cancer. Dissertation. University of Toronto.
49.
Braam KI, van Dijk EM, Veening MA, Bierings MB, Merks JH, Grootenhuis MA, Chinapaw MJ, Sinnema G, Takken T, Huisman J, Kaspers GJ, van Dulmen-den Broeder E (2010) Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer. BMC Cancer 10:624–2407–10-624
50.
Soares-Miranda L, Fiuza-Luces C, Lassaletta A, Santana-Sosa E, Padilla JR, Fernandez-Casanova L, Lorenzo-Gonzalez R, Lopez-Mojares LM, Perez M, Perez-Martinez A, Lucia A (2013) Physical Activity in Pediatric Cancer patients with solid tumors (PAPEC): trial rationale and design. Contemp Clin Trials 36:106–115CrossRefPubMed
51.
Marchese VG, Chiarello LA, Lange BJ (2004) Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 42:127–133CrossRefPubMed
52.
Moyer-Mileur LJ, Ransdell L, Bruggers CS (2009) Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol 31:259–266CrossRefPubMed
53.
Tanir MK, Kuguoglu S (2013) Impact of exercise on lower activity levels in children with acute lymphoblastic leukemia: a randomized controlled trial from Turkey. Rehabil Nurs 38:48–59CrossRefPubMed
54.
Chiang YC (2007) The effects of a home-based aerobic exercise intervention on fatigue and cardiorespiratory fitness in children with acute lymphoblastic leukemia during the maintenance stage of chemotherapy. Chang Gung University
55.
Niesen-Vertommen S (1998) The recovery patterns and effects of exercise rehabilitation on the physiological and psychological health of children who have survived treatment for a malignancy. University of British Columbia
56.
Braam K, Van Dijk-Lokkart EM, Takken T, Veening MA, Huisman J (2014) Short term effects on physical fitness of a 12-week exercise and psychosocial training program in childhood cancer patients. 61:S242–243
57.
Winningham ML (1991) Walking program for people with cancer. Getting started. Cancer Nurs 14:270–276CrossRefPubMed
58.
Higgins J, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions
59.
Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302–314CrossRefPubMed
60.
Rushton M, Clark R, Brideson G, Damarell R (2015) The effectiveness of non-pharmacological interventions for the management of cancer treatment-induced cardiotoxicity: a systematic review protocol. JBI Database System Rev Implement Rep 13:53–73PubMed
61.
Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT (2004) The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J 25:1428–1437CrossRefPubMed
62.
Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2003) Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol 42:2139–2143CrossRefPubMed
63.
Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2002) Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation 106:666–671CrossRefPubMed
64.
Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H (2009) Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301:2024–2035CrossRefPubMed
65.
Payne VG, Morrow JR Jr (1993) Exercise and VO2 max in children: a meta-analysis. Res Q Exerc Sport 64:305–313CrossRefPubMed
66.
Sharkey AM, Carey AB, Heise CT, Barber G (1993) Cardiac rehabilitation after cancer therapy in children and young adults. Am J Cardiol 71:1488–1490CrossRefPubMed
67.
Hinkle AS, Proukou C, Chen Y (2005) Pulmonary effects of antineoplastic therapy. In: Schwartz CL, Hobbie WL, Constine LS, Ruccione KS (eds) Survivors of childhood cancer and adolescent cancer, 2nd edn. Springer, Berlin, pp 161–180CrossRef
68.
Ness KK, Armenian SH, Kadan-Lottick N, Gurney JG (2011) Adverse effects of treatment in childhood acute lymphoblastic leukemia: general overview and implications for long-term cardiac health. Expert Rev Hematol 4:185–197CrossRefPubMedPubMedCentral
69.
Sontgerath R, Eckert K (2015) Impairments of lower extremity muscle strength and balance in childhood cancer patients and survivors: a systematic review. Pediatr Hematol Oncol 32:585–612CrossRefPubMed
70.
Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, Jones LW (2011) Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation 124:642–650CrossRefPubMedPubMedCentral
71.
Shirinbayan V, Roshan VD (2012) Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity. Asian Pac J Cancer Prev 13:5849–5855CrossRefPubMed
72.
Ashrafi J (2012) Cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative stress in rats. 6:2380–2388
73.
Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90:3390–3394PubMed
74.
Haykowsky MJ, Mackey JR, Thompson RB, Jones LW, Paterson DI (2009) Adjuvant trastuzumab induces ventricular remodeling despite aerobic exercise training. Clin Cancer Res 15:4963–4967CrossRefPubMed
75.
Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB (2010) Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 121:675–683CrossRefPubMedPubMedCentral
76.
Scheede-Bergdahl C, Jagoe RT (2013) After the chemotherapy: potential mechanisms for chemotherapy-induced delayed skeletal muscle dysfunction in survivors of acute lymphoblastic leukaemia in childhood. Front Pharmacol 4:49CrossRefPubMedPubMedCentral
77.
Buffart LM, Galvao DA, Brug J, Chinapaw MJ, Newton RU (2014) Evidence-based physical activity guidelines for cancer survivors: current guidelines, knowledge gaps and future research directions. Cancer Treat Rev 40:327–340CrossRefPubMed
78.
Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Cook D, Jespersen D, Proulx C, Dolan LB, Forbes CC, Wooding E, Trinh L, Segal RJ (2013) Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J Natl Cancer Inst 105:1821–1832CrossRefPubMed
79.
Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Vallerand JR, Adams SC, Proulx C, Dolan LB, Wooding E, Segal RJ (2014) Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy. Br J Cancer 111:1718–1725CrossRefPubMedPubMedCentral
80.
Burnham TR, Wilcox A (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34:1863–1867CrossRefPubMed
81.
Buffart LM, Kalter J, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Lucia A, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J (2017) Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs. Cancer Treat Rev 52:91–104CrossRefPubMed
82.
Christiansen JR, Kanellopoulos A, Lund MB, Massey R, Dalen H, Kiserud CE, Ruud E, Aakhus S (2015) Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 62:1437–1443CrossRefPubMed
83.
Martin JE, Dubbert PM (1985) Adherence to exercise. Exerc Sport Sci Rev 13:137-168CrossRef
Metadaten
Titel
Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis
verfasst von
Alexander Bourdon
Scott A. Grandy
Melanie R. Keats
Publikationsdatum
18.04.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 7/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4208-z

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