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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 11/2019

07.08.2019 | Editorial

Al18F-NOTA-octreotide and 18F-SiFAlin-TATE: two ‘new kids on the block’ in somatostatin receptor imaging

verfasst von: Karolien Goffin

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2019

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Excerpt

Since their introduction in clinical routine, somatostatin receptor agonists (SSAs) labelled with the positron-emitting radionuclide gallium-68, collectively referred to as 68Ga-DOTA-peptides, have gradually replaced the use of 111In-DTPA-octreotide for imaging of the somatostatin receptor (SSTR) in patients with neuro-endocrine tumours (NETs). Apart from the specific advantages of PET over SPECT, such as a higher sensitivity (counts/Bq) and spatial resolution, the higher affinity of 68Ga-DOTA-peptides for the SSTR-subtype 2, which is the most overexpressed SSTR-subtype in NETs, offers an additional benefit in detecting SSTR-expressing lesions. Indeed, superior performance of 68Ga-DOTA-peptide-PET was demonstrated by several groups when comparing it head-to-head to 111In-DTPA-octreotide-SPECT in patients with NETs, with mainly a significantly higher sensitivity in detecting SSTR-overexpressing lesions [1‐4]. …
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Metadaten
Titel
Al18F-NOTA-octreotide and 18F-SiFAlin-TATE: two ‘new kids on the block’ in somatostatin receptor imaging
verfasst von
Karolien Goffin
Publikationsdatum
07.08.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2019
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-019-04474-6

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