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11.12.2019 | Original Paper

Alcohol consumption and serum metabolite concentrations in young women

verfasst von: Joanne F. Dorgan, Seungyoun Jung, Cher M. Dallal, Min Zhan, Christina A. Stennett, Yuji Zhang, Richard L. Eckert, Linda G. Snetselaar, Linda Van Horn

Erschienen in: Cancer Causes & Control | Ausgabe 2/2020

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Abstract

Purpose

Alcohol consumption is an established breast cancer risk factor, though further research is needed to advance our understanding of the mechanism underlying the association. We used global metabolomics profiling to identify serum metabolites and metabolic pathways that could potentially mediate the alcohol–breast cancer association.

Methods

A cross-sectional analysis of reported alcohol consumption and serum metabolite concentrations was conducted among 211 healthy women 25–29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-Up Study (DISC06). Alcohol–metabolite associations were evaluated using multivariable linear mixed-effects regression.

Results

Alcohol was significantly (FDR p < 0.05) associated with several serum metabolites after adjustment for diet composition and other potential confounders. The amino acid sarcosine, the omega-3 fatty acid eicosapentaenoate, and the steroid 4-androsten-3beta,17beta-diol monosulfate were positively associated with alcohol intake, while the gamma-tocopherol metabolite gamma-carboxyethyl hydroxychroman (CEHC) was inversely associated. Positive associations of alcohol with 2-methylcitrate and 4-androsten-3beta,17beta-diol disulfate were borderline significant (FDR p < 0.10). Metabolite set enrichment analysis identified steroids and the glycine pathway as having more members associated with alcohol consumption than expected by chance.

Conclusions

Most of the metabolites associated with alcohol in the current analysis participate in pathways hypothesized to mediate the alcohol–breast cancer association including hormonal, one-carbon metabolism, and oxidative stress pathways, but they could also affect risk via alternative pathways. Independent replication of alcohol–metabolite associations and prospective evaluation of confirmed associations with breast cancer risk are needed.

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Children’s Hospital, New Orleans, LA; Johns Hopkins Hospital, Baltimore, MD, Kaiser Permanente Center for Health Research, Portland, OR; University of Medicine and Dentistry of New Jersey, Newark, NJ; Northwestern University Medical School, Chicago, IL; University of Iowa Hospital and Clinics, Iowa City, IA.

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Titel: Alcohol consumption and serum metabolite concentrations in young women
verfasst von: Joanne F. Dorgan
Seungyoun Jung
Cher M. Dallal
Min Zhan
Christina A. Stennett
Yuji Zhang
Richard L. Eckert
Linda G. Snetselaar
Linda Van Horn
Publikationsdatum: 11.12.2019
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 2/2020
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-019-01256-1

Springer Medizin

Alcohol consumption and serum metabolite concentrations in young women