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Erschienen in: Archives of Gynecology and Obstetrics 5/2014

01.05.2014 | Maternal-Fetal Medicine

Amniotic fluid volume in normal singleton pregnancies: modeling with quantile regression

verfasst von: Adam T. Sandlin, Songthip T. Ounpraseuth, Horace J. Spencer, Courtney L. Sick, Patrick M. Lang, Everett F. Magann

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2014

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Abstract

Purpose

To develop uniform and reliable reference ranges for amniotic fluid volume (AFV) across gestation in normal singleton pregnancies using quantile regression (QR).

Methods

An analysis of true AFVs determined by dye-dilution techniques or by direct measurement at cesarean delivery in normal singleton pregnancies. AFV centiles were established by QR, a flexible semi-parametric approach of estimating rates of change across the entire distribution of AFV rather than just in the mean as is observed with standard linear regression.

Results

The study evaluated 379 women with normal singleton pregnancies between 16 and 41 weeks gestation. QR was used to determine the association between AFV and gestational age (GA). A second-order quantile regression model indicated a nonlinear relationship between AFV and gestational age at the upper centile range (≥80th percentile).

Conclusion

This study defines normative centile charts for true AFVs between 16 and 41 weeks gestation in normal singleton pregnancies using QR. This statistical approach more appropriately reflects true AFV across gestation at each centile of interest (e.g. 5th, 50th, 95th, etc.) as compared to standard linear regression.
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Metadaten
Titel
Amniotic fluid volume in normal singleton pregnancies: modeling with quantile regression
verfasst von
Adam T. Sandlin
Songthip T. Ounpraseuth
Horace J. Spencer
Courtney L. Sick
Patrick M. Lang
Everett F. Magann
Publikationsdatum
01.05.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2014
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-013-3087-2

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