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01.12.2013 | Short Communication

An immunophenotypic and molecular diagnosis of composite hairy cell leukaemia and chronic lymphocytic leukaemia

verfasst von: Stuart Liptrot, David O’ Brien, Stephen E. Langabeer, Fiona Quinn, A. Jill Mackarel, Patrick Elder, Elisabeth Vandenberghe, Patrick J. Hayden

Erschienen in: Medical Oncology | Ausgabe 4/2013

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Abstract

Hairy cell leukaemia (HCL) and chronic lymphocytic leukaemia (CLL) are distinct clinicopathological B cell chronic lymphoproliferative disorders (B-CLPD). Both diseases have characteristic immunophenotypic and molecular features. The co-existence of two B-CLPD is perhaps more common than previously thought but a composite HCL and CLL has been rarely documented. A case is reported in which the morphology, integrated with an extensive immunophenotyping panel, and incorporation of the recently described HCL-associated BRAF V600E mutation, enabled the prompt diagnosis of composite HCL and CLL thus allowing appropriate treatment selection. This case serves to highlight the benefit of a multidisciplinary approach to the diagnosis of bi-clonal B-CLPD.

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Titel: An immunophenotypic and molecular diagnosis of composite hairy cell leukaemia and chronic lymphocytic leukaemia
verfasst von: Stuart Liptrot
David O’ Brien
Stephen E. Langabeer
Fiona Quinn
A. Jill Mackarel
Patrick Elder
Elisabeth Vandenberghe
Patrick J. Hayden
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 4/2013
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-013-0692-7

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An immunophenotypic and molecular diagnosis of composite hairy cell leukaemia and chronic lymphocytic leukaemia

Abstract

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