Erschienen in:
14.02.2019 | Images
An Uncommon Variant Hemoglobin: Hb Ty Gard Detected from Gujarat, India
verfasst von:
Anand Kumar Gyanendra Singh Wahengbam, Khushbu Kumari, Rajnish Kumar Singh, Vadlamudi Raghavendra Rao, Kallur Nava Saraswathy, Kamlesh Dharajiya, Reena Das, Benrithung Murry
Erschienen in:
Indian Journal of Hematology and Blood Transfusion
|
Ausgabe 3/2019
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Excerpt
More than 30 abnormal hemoglobins have been described in individuals of Indian and Pakistani origins which include 18 alpha chain variants, 14 beta chain variants, 2 delta chain variants, and one gamma chain variant as described in the HbVar database [
1]. A number of abnormal hemoglobin variants have been characterized, mostly occurring at very low gene frequencies. We are reporting here a variant hemoglobin with relevant molecular characterization as identified by our Thalassemia carrier screening program among various high-risk population groups of Gujarat. The preliminary test was done with complete blood count (Sysmex KX-21), hemoglobin analysis with high performance liquid chromatography (VARIANT II Hemoglobin Testing System) followed by a confirmatory molecular analysis with Sanger sequencing (ABI 3730 DNA Analyzer, Applied BioSystems). …
