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19.02.2016 | CANCER

Analgesic use and the risk of primary adult brain tumor

verfasst von: Kathleen M. Egan, Louis B. Nabors, Zachary J. Thompson, Carrie M. Rozmeski, Gabriella A. Anic, Jeffrey J. Olson, Renato V. LaRocca, Sajeel A. Chowdhary, Peter A. Forsyth, Reid C. Thompson

Erschienen in: European Journal of Epidemiology | Ausgabe 9/2016

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Abstract

Glioma and meningioma are uncommon tumors of the brain with few known risk factors. Regular use of aspirin has been linked to a lower risk of gastrointestinal and other cancers, though evidence for an association with brain tumors is mixed. We examined the association of aspirin and other analgesics with the risk of glioma and meningioma in a large US case–control study. Cases were persons recently diagnosed with glioma or meningioma and treated at medical centers in the southeastern US. Controls were persons sampled from the same communities as the cases combined with friends and other associates of the cases. Information on past use of analgesics (aspirin, other anti-inflammatory agents, and acetaminophen) was collected in structured interviews. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for analgesic use adjusted for potential confounders. All associations were considered according to indication for use. A total of 1123 glioma cases, 310 meningioma cases and 1296 controls were included in the analysis. For indications other than headache, glioma cases were less likely than controls to report regular use of aspirin (OR 0.69; CI 0.56, 0.87), in a dose-dependent manner (P trend < 0.001). No significant associations were observed with other analgesics for glioma, or any class of pain reliever for meningioma. Results suggest that regular aspirin use may reduce incidence of glioma.

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Titel: Analgesic use and the risk of primary adult brain tumor
verfasst von: Kathleen M. Egan
Louis B. Nabors
Zachary J. Thompson
Carrie M. Rozmeski
Gabriella A. Anic
Jeffrey J. Olson
Renato V. LaRocca
Sajeel A. Chowdhary
Peter A. Forsyth
Reid C. Thompson
Publikationsdatum: 19.02.2016
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 9/2016
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-016-0129-7

Springer Medizin

Abstract

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