Background
Methods
Patient database
Data statement
Main supporting software
Multivariate logistic regression analysis to determine the influence of different factors on pregnancy outcomes
Factors | Factors grouping | B | S.E, | Wals | df | Sig | Exp (B) |
---|---|---|---|---|---|---|---|
Age | < 25 | 83.775 | 4.000 | 0.000 | |||
25–30 | 0.063 | 0.106 | 0.358 | 1.000 | 0.550 | 1.065 | |
30–35 | 0.034 | 0.107 | 0.099 | 1.000 | 0.753 | 1.034 | |
35–40 | − 0.183 | 0.118 | 2.386 | 1.000 | 0.122 | 0.833 | |
> 40 | − 1.375 | 0.186 | 54.716 | 1.000 | 0.000 | 0.253 | |
DOI | Less than 1 year | 19.995 | 5.000 | 0.001 | |||
1–3 year | − 0.081 | 0.132 | 0.380 | 1.000 | 0.538 | 0.922 | |
3–6 year | − 0.104 | 0.131 | 0.631 | 1.000 | 0.427 | 0.901 | |
6–9 year | − 0.242 | 0.143 | 2.882 | 1.000 | 0.090 | 0.785 | |
9–12 year | − 0.422 | 0.167 | 6.363 | 1.000 | 0.012 | 0.656 | |
12and above | − 0.606 | 0.205 | 8.758 | 1.000 | 0.003 | 0.546 | |
EMT | Group1 | 98.562 | 3.000 | 0.000 | |||
Group2 | 0.610 | 0.103 | 34.719 | 1.000 | 0.000 | 1.840 | |
Group3 | 0.806 | 0.104 | 60.242 | 1.000 | 0.000 | 2.239 | |
Group4 | 1.105 | 0.119 | 86.471 | 1.000 | 0.000 | 3.021 | |
Endometrial pattern | A | 12.339 | 2.000 | 0.002 | |||
B | − 0.229 | 0.068 | 11.199 | 1.000 | 0.001 | 0.795 | |
C | − 0.135 | 0.088 | 2.319 | 1.000 | 0.128 | 0.874 | |
Mature follicle number | < 5 | 10.745 | 3.000 | 0.013 | |||
5–9 | 0.219 | 0.096 | 5.214 | 1.000 | 0.022 | 1.245 | |
10–14 | 0.326 | 0.102 | 10.236 | 1.000 | 0.001 | 1.385 | |
≥ 15 | 0.271 | 0.117 | 5.365 | 1.000 | 0.021 | 1.312 | |
clinical protocol | Long | 47.341 | 3.000 | 0.000 | |||
Short | − 0.232 | 0.069 | 11.325 | 1.000 | 0.001 | 0.793 | |
Prolong | 0.411 | 0.079 | 26.875 | 1.000 | 0.000 | 1.508 | |
Other | − 0.101 | 0.102 | 0.989 | 1.000 | 0.320 | 0.904 | |
P | − 0.489 | 0.078 | 39.090 | 1.000 | 0.000 | 0.613 | |
Number of embryo transfer | 0 (frozen) | 194.106 | 3.000 | 0.000 | |||
1 | 20.154 | 511.654 | 0.002 | 1.000 | 0.969 | 565,920,737.626 | |
2 | 21.041 | 511.654 | 0.002 | 1.000 | 0.967 | 1,373,929,027.313 | |
3 | 20.499 | 511.654 | 0.002 | 1.000 | 0.968 | 799,202,249.339 | |
constant | − 21.098 | 511.654 | 0.002 | 1.000 | 0.967 | 0.000 |
Prediction model
Predicting IVF results | pregnant | Not pregnant | Total |
---|---|---|---|
Successful pregnancy | 3562 (TP) | 3123 (FP) | 6685 |
Not pregnant | 94 (FN) | 6212 (TN) | 6306 |
Total | 3656 | 9335 | 12,991 |
Results
Variables | Pregnancy ( +) | Non-pregnancy ( −) | P value |
---|---|---|---|
(N = 3656) | (N = 9335) | ||
Age (years) | 30.18 ± 4.13 | 32.42 ± 5.75 | < 0.01 |
BMI (kg/m2) | 21.88 ± 2.93 | 21.93 ± 2.90 | 0.3278 |
Cycle protocols | < 0.01 | ||
Long agonist protocol | 2302 (63.0%) | 4423 (47.4%) | |
Short agonist protocol | 575 (15.7%) | 1870 (20.0%) | |
Prolonged agonist protocol | 565 (15.5%) | 857 (9.2%) | |
Other | 214 (5.9%) | 2185 (23.4%) | |
Duration of infertility (years) | 3.67 ± 2.68 | 4.25 ± 3.61 | < 0.01 |
FSH (mIU/ml) | 7.38 ± 2.57 | 8.05 ± 3.65 | < 0.01 |
embryo transferred | 1.86 ± 0.34 | 0.66 ± 0.87 | < 0.01 |
HMG | 8.05 ± 7.54 | 9.74 ± 8.92 | < 0.01 |
Gntime | 10 ± 1.78 | 9.82 ± 2.05 | < 0.01 |
mature follicles | 9.97 ± 3.93 | 9.47 ± 5.67 | < 0.01 |
endometrial thickness on HCGday | 11.68 ± 2.38 | 10.54 ± 2.81 | < 0.01 |
E2 | 3362.93 ± 1756.74 | 3477.31 ± 2652.94 | 0.004228 |
Progesterone (ng/ml) | 0.9 ± 0.30 | 1.23 ± 1.72 | < 0.01 |
oocytes retrieved (n) | 11.31 ± 4.59 | 11.33 ± 7.94 | 0.8667 |
endometrial morphology | < 0.01 | ||
a | 2801 (76.6%) | 5754 (61.6%) | |
b | 539 (14.7%) | 1895 (20.3%) | |
c | 316 (8.6%) | 1686 (18.1%) |
Variables | Pregnancy ( +) | Non-pregnancy ( −) |
---|---|---|
(N = 3656) | (N = 9335) | |
Ovary-related factors | 114 (3.1%) | 481 (5.2%) |
Tubal related factors | 756 (20.7%) | 1599 (17.1%) |
Endometriosis | 42 (1.1%) | 88 (0.9%) |
Male factors | 343 (9.4%) | 705 (7.6%) |
Uterine factors | 37 (1%) | 81 (0.8%) |
Other | 1344 (36.8%) | 3408 (36.5%) |
Multiple causes | 1020 (27.9%) | 2973 (31.8%) |
Statistics of patients with different endometrial patterns
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 785) | (N = 3476) | (N = 3345) | (N = 949) | ||
Age (years) | 34.42 ± 6.02 | 31.32 ± 5.00 | 30.4 ± 4.53 | 30.09 ± 4.34 | < 0.01 |
Duration of infertility (years) | 4.35 ± 4.05 | 3.91 ± 3.16 | 3.95 ± 3.01 | 3.81 ± 2.79 | 0.00159 |
Clinical protocol | < 0.01 | ||||
Long agonist protocol | 224 (28.5%) | 1877 (54.0%) | 1973 (59%) | 570 (60.1%) | |
Short agonist protocol | 140 (17.8%) | 837(24.1%) | 589 (17.6%) | 121 (12.8%) | |
Prolonged agonist protocol | 64 (8.2%) | 352 (10.1%) | 548 (16.4%) | 198 (20.9%) | |
Other | 357 (45.5%) | 410 (11.8%) | 235 (7.0%) | 60 (6.3%) | |
Embryo transferred | 0.65 ± 0.88 | 1.13 ± 0.92 | 1.21 ± 0.90 | 1.18 ± 0.91 | < 0.01 |
Progesterone(ng/ml) | 1.08 ± 2.34 | 1.05 ± 0.63 | 1.03 ± 0.48 | 1.01 ± 0.41 | 0.261 |
Clinical pregnancy | 96 (12.2%) | 1071 (30.8%) | 1250 (37.4%) | 384 (40.5%) | < 0.01 |
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 427) | (N = 864) | (N = 769) | (N = 374) | ||
Age (years) | 35.86 ± 5.79 | 32.54 ± 5.47 | 30.85 ± 5.13 | 30.93 ± 4.66 | < 0.01 |
Duration of infertility (years) | 5.17 ± 4.70 | 4.37 ± 3.50 | 4.41 ± 3.58 | 4.23 ± 3.35 | 0.000804 |
Clinical protocol | < 0.01 | ||||
Long agonist protocol | 123 (28.8%) | 499 (57.8%) | 548 (71.3%) | 271 (72.5%) | |
Short agonist protocol | 63 (14.8%) | 163 (18.9%) | 105 (13.7%) | 52 (13.9%) | |
Prolonged agonist protocol | 6 (1.4%) | 12 (1.4%) | 13 (1.7%) | 9 (2.4%) | |
Other | 235 (55.0%) | 190 (22.0%) | 103 (13.4%) | 42 (11.2%) | |
Embryo transferred | 0.53 ± 0.81 | 0.87 ± 0.92 | 1.05 ± 0.93 | 1.07 ± 0.92 | < 0.01 |
Progesterone(ng/ml) | 1.49 ± 2.87 | 1.51 ± 3.05 | 1.24 ± 1.29 | 1.18 ± 1.60 | 0.0352 |
Clinical pregnancy | 32 (7.5%) | 161 (18.6%) | 214 (27.8%) | 132 (35.2%) | < 0.01 |
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 549) | (N = 631) | (N = 543) | (N = 279) | ||
Age (years) | 37.77 ± 5.88 | 34.03 ± 6.44 | 31.6 ± 5.31 | 31.3 ± 5.00 | < 0.01 |
Duration of infertility (years) | 4.16 ± 4.17 | 4.16 ± 3.86 | 4.14 ± 3.46 | 4.21 ± 3.37 | 0.994 |
Clinical protocol | < 0.01 | ||||
Long agonist protocol | 49 (9.0%) | 202 (32.0%) | 249 (45.9%) | 140 (50.2%) | |
Short agonist protocol | 47 (8.6%) | 125 (19.8%) | 136 (25.0%) | 67 (24.0%) | |
Prolonged agonist protocol | 30 (5.5%) | 60 (9.5%) | 85 (15.7%) | 45 (16.1%) | |
Other | 423 (77.0%) | 244 (38.7%) | 73 (13.4%) | 27 (9.7%) | |
Embryo transferred | 0.16 ± 0.53 | 0.55 ± 0.85 | 0.84 ± 0.94 | 0.94 ± 0.95 | < 0.01 |
Progesterone (ng/ml) | 1.11 ± 1.21 | 1.36 ± 1.91 | 1.41 ± 2.12 | 1.29 ± 2.61 | 0.0418 |
Clinical pregnancy | 14 (2.6%) | 89(14.1%) | 129 (23.8%) | 84 (30.1%) | < 0.01 |
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 396) | (N = 2578) | (N = 2770) | (N = 981) | ||
Age (years) | 30.89 ± 5.88 | 30.22 ± 5.02 | 29.89 ± 4.44 | 29.89 ± 4.56 | < 0.01 |
Duration of infertility (years) | 3.49 ± 3.98 | 3.91 ± 3.16 | 3.84 ± 2.95 | 4.01 ± 2.55 | 0.00188 |
Endometrial patterns | < 0.01 | ||||
A | 224 (56.6%) | 1877 (72.8%) | 1973 (71.2%) | 570 (58.1%) | |
B | 123 (31%) | 409 (15.9%) | 548 (19.9%) | 271 (27.6%) | |
C | 49 (12.4%) | 202 (7.8%) | 249 (9%) | 140 (14.3%) | |
Embryo transferred | 1.06 ± 0.85 | 1.19 ± 0.88 | 1.21 ± 0.91 | 1.17 ± 0.88 | < 0.01 |
Progesterone(ng/ml) | 1.09 ± 2.22 | 1.1 ± 0.44 | 1.05 ± 0.42 | 1.03 ± 0.38 | 0.181 |
Clinical pregnancy | 74 (18.7%) | 831 (32.2%) | 1006 (36.3%) | 391 (39.9%) | < 0.01 |
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 396) | (N = 2578) | (N = 2770) | (N = 981) | ||
Age (years) | 30.89 ± 5.88 | 30.22 ± 5.02 | 29.89 ± 4.44 | 29.89 ± 4.56 | < 0.01 |
Duration of infertility (years) | 3.49 ± 3.98 | 3.91 ± 3.16 | 3.84 ± 2.95 | 4.01 ± 2.55 | 0.00188 |
Endometrial patterns | < 0.01 | ||||
A | 224 (56.6%) | 1877 (72.8%) | 1973 (71.2%) | 570 (58.1%) | |
B | 123 (31%) | 409 (15.9%) | 548 (19.9%) | 271 (27.6%) | |
C | 49 (12.4%) | 202 (7.8%) | 249 (9%) | 140 (14.3%) | |
Embryo transferred | 1.06 ± 0.85 | 1.19 ± 0.88 | 1.21 ± 0.91 | 1.17 ± 0.88 | < 0.01 |
Progesterone(ng/ml) | 1.09 ± 2.22 | 1.1 ± 0.44 | 1.05 ± 0.42 | 1.03 ± 0.38 | 0.181 |
Clinical pregnancy | 74 (18.7%) | 831 (32.2%) | 1006 (36.3%) | 391 (39.9%) | < 0.01 |
Variables | Group1 | Group2 | Group3 | Group4 | P value |
---|---|---|---|---|---|
(N = 100) | (N = 424) | (N = 646) | (N = 252) | ||
Age (years) | 31.81 ± 5.93 | 30.62 ± 4.83 | 29.8 ± 4.34 | 29.76 ± 4.39 | < 0.01 |
Duration of infertility (years) | 3.49 ± 3.71 | 3.51 ± 3.24 | 3.72 ± 2.77 | 3.42 ± 2.55 | 0.00103 |
Endometrial patterns | < 0.01 | ||||
A | 64 (64%) | 352 (83%) | 548 (84.8%) | 198 (78.62%) | |
B | 6 (6%) | 12 (2.8%) | 13 (2%) | 9 (3.6%) | |
C | 30 (30%) | 60 (14.2%) | 85 (13.2%) | 45 (17.9%) | |
Embryo transferred | 0.91 ± 0.72 | 1.13 ± 0.83 | 1.16 ± 0.78 | 1.17 ± 0.91 | < 0.01 |
Progesterone(ng/ml) | 1.23 ± 1.99 | 1.14 ± 0.44 | 1.11 ± 0.42 | 1.07 ± 0.36 | 0.196 |
Clinical pregnancy | 25 (25%) | 166 (39.2%) | 270 (41.8%) | 104 (41.2%) | < 0.01 |
Influence of different factors on pregnancy outcomes
-
Pattern A: group 1 (12.2%), group 2 (30.8%), group 3 (37.4%), and group 4 (40.5%);
-
Pattern B: group 1 (7.5%), group 2 (18.6%), group 3 (27.8%), and group 4 (35.2%); and
-
Pattern C: group 1 (2.6%), group 2 (14.1%), group 3 (23.8%), and group 4 (30.1%).
Predictors | OR (95%CI) | P |
---|---|---|
Clinical protocol | < 0.001a | |
Long agonist protocol | * | |
Short agonist protocol | 0.7 (0.62, 0.8) | < 0.001 |
Prolonged agonist protocol | 1.4 (1.2, 1.64) | < 0.001 |
Other | 0.85 (0.7, 1.03) | 0.1 |
Duration of infertility | 0.97 (0.95, 0.98) | < 0.001 |
Endometrial thickness | 1.12 (1.09, 1.14) | < 0.001a |
Endometrial morphology | < 0.001 | |
a | * | |
b | 0.8 (0.7, 0.92) | 0.001 |
c | 0.72 (0.61, 0.86) | < 0.001 |
Age | 0.96 (0.94, 0.97) | < 0.001 |
Progesterone | 0.63 (0.54, 0.73) | < 0.001 |
ET | 7.12 (6.52, 7.77) | < 0.001 |
Prediction results
Group | Predicted pregnancy rate (%) | Average predicted pregnancy rate (%) | Average predicted number of infants | Actual pregnancy | The total number of cycles in the group | Actual pregnancy rate (%) | Error rate (%) |
---|---|---|---|---|---|---|---|
1 | < 28.45 | 2.26 | 147 | 151 | 6499 | 2.32 | − 0.06 |
2 | 28.45–42.18 | 35.81 | 466 | 466 | 1301 | 35.81 | 0 |
3 | 42.18–52.27 | 48.07 | 614 | 653 | 1278 | 51.09 | − 3.02 |
4 | 52.27–57.42 | 55.06 | 730 | 728 | 1325 | 54.94 | 0.01 |
5 | 57.42–62.55 | 59.67 | 766 | 781 | 1284 | 60.82 | − 1.15 |
6 | > 62.55 | 67.35 | 879 | 877 | 1304 | 67.25 | 0.10 |
Total | < 62.55 | 27.73 | 3602 | 3656 | 12,991 | 28.14 | − 0.41 |