Background
Methods
Study design
Data preparation
Analysis with IPA
Mining analysis of mutual targets
Results
Herbal names (Latin) | Hepatorenal toxicity | Effect | Molecular ingredients (CAS number) | Targets |
---|---|---|---|---|
Ba ji tian (Radix Morindae officinalis) | None | tonifying kidney-Yang | Aascorbic acid (CAS:1972-08-3) | PTGER3, TGFA, VEGFA, FTMT, SLC11A2, and other 42 targets |
Ci wu jia (Radix seu Caulis et Folium Acanthopana) | None | tonifying kidney-Yang | Sesamin (CAS:607-80-7) | NOS3, NOX1, UGT1A1, CYP2B6, CCND1, and other 12 targets |
Du zhong (Cortex Eucommiae) | None | tonifying kidney-Yang | Aucubin (CAS:479-98-1) | BCL2, BAX, TNF, IL6, RELA, NFKBIA, and other 27 targets |
Bu gu zhi (Fructus Psoraleae) | long-term risks of causing kidney disease | tonifying kidney-Yang | Angelicin (CAS:523-50-2) | CYP1A1, ESR1, ESR2, ESTRB, NR3A2, and other 27 targets |
Di huang (Radix Rehmanniae) | None | tonifying kidney-Yin | Catalpol (CAS:2415-24-9) | NOS2, SOD1, CASP3, BCL2, ICAM1, and other 14 targets |
Nv zhen (Radix Ligustri lucidi) | None | tonifying kidney-Yin | Ursolic acid (CAS:77-52-1) | JUN, PTGS2, ACHE, MMP9, RELA, and other 39 targets |
Sang shen (Fructus Mori) | None | tonifying kidney-Yin | Morin (CAS:480-16-0) | XDH, PIP4K2A, ALOX5, CD36, BATF3, and other 58 targets |
Gou qi zi (Fructus Lycii) | None | tonifying kidney-Yin | Beta-carotene (CAS:7235-40-7) | CYP3A4, Cyp2b1, CYP1A2, HMOX1, ALB, and other 77 targets |
Results of IPA Analysis
Result of global kidney-tonifying herbal medicines with anti-aging effect
Targets in network | Score | Top related Bio Functions and Diseases |
---|---|---|
ALB, APOB, ATF2, AUH, BCL2, CD40LG, CREB1, CUTA, DDIT3, ELANE, IL6, and other 62 targets | 38 | Cell Death and Survial, Cardiovascular Disease, Gene Expression |
ALOX5, CAV1, CCND1, CDK2, CDK4, CRYZ, CTNNB1, EDN1, EGR1, ESR2, FGF2, and other 47 targets | 27 | Cancer, Organismal Injury and Abnormalities, Cellular Development |
CSD2, DBI, DUOX2, F3, HMOX1, ICAM1, IL4, IL10, IL13, MAOA, MIOX, NOS2, and other 39 targets | 26 | Free Radical Scavenging, Cell to Cell Signaling and Interaction, Cardiovascular Disease |
APP, AR, CASO3, CDKN1A, CXCL8, EGF, FASLG, FN1, HIF1A, IL2, ITGAM, MAPK1, and other 86 targets | 25 | Gene Expression, Cell Death and Survial, Cancer |
ACTA2, ATPC1, BTK, CAPN1, CCL20, CTSB, IL1A, ITGAL, ITGB1, KCNMA1, TP53, and other 106 targets | 22 | Cellular Growth and Proliferation, Connective Tissue Development |
Result of kidney Yang-tonifying herbal medicines and kidney Yin-tonifying herbal medicines with anti-aging effect
Result of data mining of mutual target proteins
Result of enrichment analysis
Biological process | P value | Ratio | Involved targets |
---|---|---|---|
response to chemical stimulus | 7.95E-15 | 0.61 | TNF, CCL2, PTGS2, TNC, TH, MME, TGFB1, VCAM1, and other 5 targets |
response to stress | 8.55E-13 | 0.61 | TNF, CCL2, PTGS2, TNC, TH, MME, TGFB1, SLC11A2, and other 12 targets |
response to stimulus | 1.66E-11 | 0.77 | TNF, CCL2, PTGS2, TNC, TH, MME, TGFB1, VCAM1, and other 6 targets |
response to inorganic substance | 1.66E-11 | 0.29 | CUTA, PTGS2, CYP1A1, OLR1, RELA, TNC, SOD1, SOD3, and other 11 targets. |
response to wounding | 4.25E-10 | 0.35 | IL6, TNF, CCL2, OLR1, CYP1A1, RELA, TNC, MME, and other 9 targets |
regulation of immune system process | 1.90E-09 | 0.31 | ICAM1, IL6, TNF, CCL2, RELA, SOD1, TGFB1, VCAM1, and other 7 targets |
response to drug | 1.19E-08 | 0.24 | CCL2, TNF, CYP1A1, PTGS2, JUN, RELA, MME, IL1B, and other 13 targets |
positive regulation of response to stimulus | 1.77E-08 | 0.24 | IL6, CCL2, TNF, PTGER3, PTGS2, CD40LG, RELA, and other 17 targets |