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Clinical Orthopaedics and Related Research®

Erschienen in:

01.10.2011 | Basic Research

Androgen Receptor CAG Repeat Size is Associated with Stress Fracture Risk: A Pilot Study

verfasst von: Ran Yanovich, MSc, Roni Milgrom, MSc, Eitan Friedman, MD, PhD, Daniel S. Moran, PhD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 10/2011

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Abstract

Background

Stress fractures commonly affect military recruits during basic training. Several lines of evidence suggest genetic factors are involved in stress fracture predisposition. As gender steroid hormone levels and activity have been implicated in affecting bone strength, one of the candidate genes likely to be involved is the androgen receptor gene.

Questions/purposes

We assessed the possible involvement of the androgen receptor gene in stress fracture predisposition in Israeli soldiers.

Patients and Methods

Between January 2007 and December 2009, we collected clinical and imaging data from 454 Israeli soldiers referred for bone scans with clinical symptoms compatible with stress fractures: 171 soldiers (154 men, 17 women) (patients) with bone scan-proven stress fractures and 283 soldiers (242 men, 41 women) with normal bone scans (control subjects). All participants were genotyped for the length of the CAG (cytosine-adenine-guanine) repeat in exon 1 of the androgen receptor gene using PCR and subsequent fragment analysis on sequence analyzer.

Results

The androgen receptor gene CAG repeat was ranged between six and 31 (mean ± SD, 20.6 ± 4.3) among patients and between 11 and 32 (mean ± SD, 20.0 ± 3.8) among control subjects. Smaller-sized (< 16) androgen receptor CAG repeats were more prevalent among control subjects (23%) than among patients (13%); the risk for having SFs was almost halved if the size of the repeat was shorter than 16 repeats.

Conclusions

The androgen receptor gene CAG repeat has a different allele distribution among Israeli soldiers with stress fractures than in control subjects. While our finding must be validated, it could be used for screening individuals at risk for stress fractures.

Level of Evidence

Level II, prognostic study. See the Guidelines for Authors complete description of levels of evidence.

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Titel: Androgen Receptor CAG Repeat Size is Associated with Stress Fracture Risk: A Pilot Study
verfasst von: Ran Yanovich, MSc
Roni Milgrom, MSc
Eitan Friedman, MD, PhD
Daniel S. Moran, PhD
Publikationsdatum: 01.10.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 10/2011
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-011-1805-2

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Abstract

Background

Questions/purposes

Patients and Methods

Results

Conclusions

Level of Evidence

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