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01.03.2013 | Original paper

Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

verfasst von: Fatemeh Saberi Hosnijeh, Isabelle Romieu, Valentina Gallo, Elio Riboli, Anne Tjønneland, Jytte Halkjær, Guy Fagherazzi, Françoise Clavel-Chapelon, Laure Dossus, Annie Lukanova, Rudolf Kaaks, Antonia Trichopoulou, Pagona Lagiou, Michael Katsoulis, Salvatore Panico, Giovanna Tagliabue, Catalina Bonet, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Maria-José Sánchez, Dorthe Johansen, Signe Borgquist, Petra Peeters, H. Bas Bueno-de-Mesquita, Martine M. Ros, Ruth C. Travis, Timothy J. Key, Paolo Vineis, Roel Vermeulen

Erschienen in: Cancer Causes & Control | Ausgabe 3/2013

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Abstract

Purpose

Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).

Methods

During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia.

Results

No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height.

Conclusion

The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.

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Titel: Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
verfasst von: Fatemeh Saberi Hosnijeh
Isabelle Romieu
Valentina Gallo
Elio Riboli
Anne Tjønneland
Jytte Halkjær
Guy Fagherazzi
Françoise Clavel-Chapelon
Laure Dossus
Annie Lukanova
Rudolf Kaaks
Antonia Trichopoulou
Pagona Lagiou
Michael Katsoulis
Salvatore Panico
Giovanna Tagliabue
Catalina Bonet
Miren Dorronsoro
José María Huerta
Eva Ardanaz
Maria-José Sánchez
Dorthe Johansen
Signe Borgquist
Petra Peeters
H. Bas Bueno-de-Mesquita
Martine M. Ros
Ruth C. Travis
Timothy J. Key
Paolo Vineis
Roel Vermeulen
Publikationsdatum: 01.03.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 3/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-0128-2

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Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)