Erschienen in:
14.03.2023 | Case Report - Diagnosis
Anti-Mi-2 antibody-positive lung cancer-associated polymyositis
verfasst von:
Masafumi Shimoda, Yoshiaki Tanaka, Atsuo Taniguchi, Kozo Morimoto, Kozo Yoshimori, Ken Ohta
Erschienen in:
International Cancer Conference Journal
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Ausgabe 3/2023
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Abstract
After a 75-year-old man was diagnosed with lung cancer, proximal weakness and myalgia in the bilateral lower extremities developed, and the creatinine kinase (CK) level was elevated. The anti-Mi-2 antibody test was positive, muscle T2-weighted/fat-suppressed magnetic resonance imaging showed high intensity, and there were no skin lesions. Therefore, he was diagnosed with lung cancer-associated polymyositis (PM). The lung tumour shrank after chemotherapy, accompanied by gradual improvement of his PM-derived symptoms and CK level. Although positive anti-Mi-2 antibody tests rarely indicate PM and cancer, examining myositis-specific autoantibodies, including anti-Mi-2, should be considered if the CK level increases after a cancer diagnosis.