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Current Psychiatry Reports
Erschienen in: Current Psychiatry Reports 11/2023

27.09.2023

Antipsychotic-Induced Weight Gain in Severe Mental Illness: Risk Factors and Special Considerations

verfasst von: Nicolette Stogios, Bailey Humber, Sri Mahavir Agarwal, Margaret Hahn

Erschienen in: Current Psychiatry Reports | Ausgabe 11/2023

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Abstract

Purpose of Review

Weight gain is a disconcerting issue experienced by patients treated with antipsychotics (APs). This review summarizes current knowledge on the prevalence, etiology, and risk factors for antipsychotic-induced weight gain (AIWG), and evidence for interventions, including special considerations.

Recent Findings

Predisposing risk factors for AIWG include lack of prior AP exposure, sex, and age. AP dose and duration of exposure are additional treatment-related factors that may contribute to this issue. Among current approaches to target AIWG, metformin has the most evidence to support its use, and this is increasingly reflected in clinical guidelines. While lifestyle approaches are recommended, cost-effectiveness and scalability represent limitations.

Summary

More research is needed to identify newer treatment options and inform clinical recommendations for AIWG. Concerns around scope of practice in psychiatry to address AIWG and related comorbidities will require enhanced training opportunities and interdisciplinary collaborations, as well as updated position statements/practice guidelines emphasizing prevention.
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Metadaten
Titel
Antipsychotic-Induced Weight Gain in Severe Mental Illness: Risk Factors and Special Considerations
verfasst von
Nicolette Stogios
Bailey Humber
Sri Mahavir Agarwal
Margaret Hahn
Publikationsdatum
27.09.2023
Verlag
Springer US
Erschienen in
Current Psychiatry Reports / Ausgabe 11/2023
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-023-01458-0

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