Erschienen in:
01.12.2000 | Paper Report
APCgene mutations in human breast cancers
verfasst von:
Chris Jones
Erschienen in:
Breast Cancer Research
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Ausgabe 1/2000
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Excerpt
The importance of APC gene mutations in the initiation step of both familial and sporadic colorectal carcinogenesis is well known. Somatic mutations of this gene have also been implicated in pancreatic, gastric and oesophageal cancers. In contrast, only a few APC mutations have been reported in primary human breast cancers. The vast majority of reported APC mutations are protein-truncating, and a novel yeast-based screening method for detection of truncating mutations is presented here. …