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Erschienen in: Breast Cancer Research 1/2000

01.12.2000 | Paper Report

APCgene mutations in human breast cancers

verfasst von: Chris Jones

Erschienen in: Breast Cancer Research | Ausgabe 1/2000

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Excerpt

The importance of APC gene mutations in the initiation step of both familial and sporadic colorectal carcinogenesis is well known. Somatic mutations of this gene have also been implicated in pancreatic, gastric and oesophageal cancers. In contrast, only a few APC mutations have been reported in primary human breast cancers. The vast majority of reported APC mutations are protein-truncating, and a novel yeast-based screening method for detection of truncating mutations is presented here. …
Literatur
1.
Zurück zum Zitat Furuuchi K, Tada M, Yamada H, Kataoka A, Furuuchi N, Hamada J, Takahashi M, Todo S, Moriuchi T: Somatic mutations of the APCgene in primary breast cancers. Am J Pathol. 2000, 156: 1997-2005. CrossRefPubMedPubMedCentral Furuuchi K, Tada M, Yamada H, Kataoka A, Furuuchi N, Hamada J, Takahashi M, Todo S, Moriuchi T: Somatic mutations of the APCgene in primary breast cancers. Am J Pathol. 2000, 156: 1997-2005. CrossRefPubMedPubMedCentral
Metadaten
Titel
APCgene mutations in human breast cancers
verfasst von
Chris Jones
Publikationsdatum
01.12.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2000-66710

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