Introduction
Materials and methods
Participants
PD prescription
Data collection
Statistical analysis
Results
Demographic and baseline characteristics of subjects
APD group (n = 42) | APD–CAPD group (n = 28) | CAPD group (n = 26) | P value† | |
---|---|---|---|---|
Male, n (%) | 23 (54.8) | 14 (50.0) | 13 (50.0) | 0.898 |
Age (years) | 51.88 ± 13.49 | 55.00 ± 16.61 | 55.74 ± 9.77 | 0.527 |
Systolic blood pressure (mmHg) | 152.70 ± 16.90 | 147.70 ± 18.00 | 154.90 ± 20.89 | 0.418 |
Diabetic nephropathy, n (%) | 15 (35.7) | 12 (42.8) | 8 (30.8) | 0.648 |
Medication, n (%) | ||||
Antihypertensive agents | 30 (71.4) | 22 (67.9) | 19 (73.1) | 0.795 |
Anemia-improving agents* | 31 (73.8) | 22 (78.6) | 18 (69.2) | 0.737 |
Phosphorus-reducing agents | 22 (52.4) | 14 (50.0) | 15 (57.7) | 0.845 |
Blood urea nitrogen (mmol/L) | 25.05 ± 8.97 | 22.66 ± 9.12 | 21.29 ± 7.17 | 0.195 |
Creatinine (umol/L) | 853.40 ± 233.15 | 811.10 ± 225.99 | 824.30 ± 279.70 | 0.761 |
Uric acid (umol/L) | 445.80 ± 108.00 | 437.70 ± 126.78 | 434.60 ± 88.64 | 0.907 |
iPTH (pg/mL) | 418.90 ± 193.32 | 447.90 ± 165.40 | 445.90 ± 228.64 | 0.845 |
Serum potassium (mmol/L) | 4.72 ± 0.77 | 4.60 ± 0.72 | 4.63 ± 0.75 | 0.803 |
Serum calcium (mmol/L) | 2.02 ± 0.27 | 2.08 ± 0.23 | 2.11 ± 0.25 | 0.323 |
Serum phosphorus (mmol/L) | 1.99 ± 0.73 | 1.89 ± 0.59 | 1.92 ± 0.71 | 0.805 |
Serum sodium (mmol/L) | 140.20 ± 2.95 | 140.10 ± 3.53 | 140.90 ± 5.06 | 0.735 |
CO2-CP (mmol/L) | 22.24 ± 2.39 | 21.73 ± 3.07 | 22.58 ± 3.04 | 0.532 |
Albumin (g/L) | 35.13 ± 6.12 | 33.87 ± 5.44 | 32.93 ± 5.52 | 0.298 |
Pre-albumin (mg/L) | 301.20 ± 76.53 | 291.70 ± 52.59 | 289.20 ± 75.21 | 0.751 |
Total protein (g/L) | 65.06 ± 11.19 | 65.56 ± 9.18 | 64.15 ± 8.71 | 0.872 |
Fasting plasma glucose (mmol/L | 5.61 ± 1.55 | 5.65 ± 1.78 | 5.57 ± 1.06 | 0.984 |
Hemoglobin (g/L) | 80.69 ± 13.43 | 82.54 ± 12.46 | 81.35 ± 14.67 | 0.855 |
eGFR (mL/min/1.73 m2)# | 5.71 ± 2.10 | 5.52 ± 1.69 | 6.40 ± 2.29 | 0.312 |
Urine volume (mL) | 1352.00 ± 303.57 | 1381.00 ± 446.44 | 1581.00 ± 545.54 | 0.149 |
Comparison of changes in parameters among groups after treatment during the break-in period
APD group (n = 42) |
P
| APD–CAPD group (n = 28) |
P
| CAPD group (n = 26) |
P
| |
---|---|---|---|---|---|---|
Toxins | ||||||
Blood urea nitrogen (mmol/L) | 14.41 ± 5.68 | 0.000 | 13.51 ± 4.03 | 0.000 | 16.40 ± 5.43 | 0.008 |
Creatinine (umol/L) | 657.80 ± 193.71 | 0.000 | 627.30 ± 154.41 | 0.001 | 711.00 ± 258.94 | 0.136 |
Uric acid (umol/L) | 370.60 ± 73.48 | 0.000 | 357.80 ± 107.32 | 0.014 | 404.50 ± 87.20 | 0.223 |
Electrolytes | ||||||
Serum potassium (mmol/L) | 3.80 ± 0.50 | 0.000 | 3.75 ± 0.51 | 0.000 | 4.17 ± 0.51 | 0.012 |
Serum calcium (mmol/L) | 2.12 ± 0.25 | 0.069 | 2.17 ± 0.25 | 0.154 | 2.23 ± 0.31 | 0.132 |
Serum phosphorus (mmol/L) | 1.43 ± 0.38 | 0.000 | 1.27 ± 0.27 | 0.000 | 1.68 ± 0.47 | 0.160 |
Serum sodium (mmol/L) | 139.00 ± 3.75 | 0.094 | 141.20 ± 3.50 | 0.277 | 141.50 ± 3.34 | 0.589 |
CO2-CP (mmol/L) | 24.51 ± 2.70 | 0.000 | 24.93 ± 3.75 | 0.001 | 24.48 ± 2.01 | 0.010 |
Nutritional indicators | ||||||
Albumin (g/L) | 29.81 ± 4.85 | 0.000 | 31.33 ± 5.32 | 0.083 | 32.32 ± 5.38 | 0.691 |
Pre-albumin (mg/L) | 268.60 ± 87.23 | 0.072 | 299.60 ± 107.41 | 0.728 | 302.20 ± 83.05 | 0.556 |
Total protein (g/L) | 58.30 ± 8.70 | 0.003 | 61.72 ± 8.83 | 0.117 | 60.19 ± 7.18 | 0.080 |
Others | ||||||
FPG (mmol/L) | 5.32 ± 0.87 | 0.302 | 5.46 ± 0.92 | 0.622 | 5.58 ± 1.27 | 0.983 |
Hemoglobin (g/L) | 81.26 ± 15.34 | 0.856 | 83.00 ± 11.44 | 0.885 | 85.19 ± 13.86 | 0.336 |
APD group (n = 42) | APD–CAPD group (n = 28) | CAPD group (n = 26) |
P
a
|
P
b
|
P
c
| |
---|---|---|---|---|---|---|
Toxins | ||||||
Blood urea nitrogen (mmol/L) | − 10.64 ± 6.66 | − 9.15 ± 6.78 | − 4.89 ± 3.57 | 0.367 | 0.000 | 0.006 |
Creatinine (umol/L) | − 195.50 ± 114.84 | − 183.80 ± 161.41 | − 113.50 ± 61.73 | 0.723 | 0.042 | 0.001 |
Uric acid (umol/L) | − 75.14 ± 67.62 | − 79.86 ± 56.42 | − 30.12 ± 56.83 | 0.762 | 0.006 | 0.002 |
Electrolytes | ||||||
Serum potassium (mmol/L) | − 0.91 ± 0.78 | − 0.86 ± 0.72 | − 0.46 ± 0.53 | 0.763 | 0.012 | 0.027 |
Serum calcium (mmol/L) | 0.11 ± 0.32 | 0.09 ± 0.31 | 0.12 ± 0.23 | 0.879 | 0.860 | 0.743 |
Serum phosphorus (mmol/L) | − 0.57 ± 0.61 | − 0.61 ± 0.63 | − 0.24 ± 0.38 | 0.752 | 0.017 | 0.011 |
Serum sodium (mmol/L) | − 1.25 ± 4.83 | 1.03 ± 4.63 | 0.65 ± 3.01 | 0.053 | 0.078 | 0.720 |
CO2-CP (mmol/L) | 2.27 ± 2.95 | 3.20 ± 3.87 | 1.91 ± 3.92 | 0.261 | 0.665 | 0.968 |
Nutritional indicators | ||||||
Albumin (g/L) | − 5.30 ± 4.70 | − 2.54 ± 4.37 | − 0.60 ± 5.12 | 0.016 | 0.000 | 0.140 |
Pre-albumin (mg/L) | − 32.64 ± 66.39 | 7.89 ± 90.43 | 13.04 ± 80.97 | 0.035 | 0.014 | 0.827 |
Total protein (g/L) | − 6.76 ± 5.78 | − 3.87 ± 6.66 | − 3.96 ± 4.98 | 0.059 | 0.045 | 0. 958 |
Others | ||||||
FPG (mmol/L) | − 0.28 ± 1.62 | − 0.19 ± 1.71 | 0.01 ± 1.56 | 0.813 | 0.469 | 0.665 |
Hemoglobin (g/L) | 0.57 ± 10.50 | 0.46 ± 13.03 | 3.85 ± 7.55 | 0.970 | 0.172 | 0.253 |
Comparison of PD-related complications of three PD modes during the break-in period
Complications, n (%) | APD group (n = 42) | APD–CAPD group (n = 28) | CAPD group (n = 26) | Total (n = 98) | P value |
---|---|---|---|---|---|
Catheter migration | 4 (9.5) | 3 (10.7) | 2 (7.7) | 9 (9.2) | 0.929 |
PD fluid leakage | 2 (4.8) | 1 (3.6) | 1 (3.8) | 4 (4.1) | 0.966 |
Abdominal pain | 3 (7.1) | 3 (10.7) | 2 (7.7) | 8 (8.2) | 0.861 |
Abdominal distention | 2 (4.8) | 1 (3.6) | 1 (3.8) | 4 (4.1) | 0.966 |
Catheter obstruction | 1 (2.4) | 1 (3.6) | 1 (3.8) | 3 (3.1) | 0.932 |
PD-related peritonitis | 1 (2.4) | 0 | 1 (3.8) | 2 (2.0) | 0.603 |
Catheter-related peritonitis | 1 (2.4) | 1 (3.6) | 2 (7.7) | 4 (4.1) | 0.557 |
Comparison of changes in parameters among groups at a month after treatment
APD group (n = 42) |
P
| APD–CAPD group (n = 28) |
P
| CAPD group (n = 26) |
P
| |
---|---|---|---|---|---|---|
Toxins | ||||||
Blood urea nitrogen (mmol/L) | 14.07 ± 4.76 | 0.000 | 13.42 ± 4.79 | 0.001 | 11.54 ± 3.71 | 0.000 |
Creatinine (umol/L) | 694.40 ± 186.75 | 0.003 | 610.20 ± 185.66 | 0.004 | 638.10 ± 211.03 | 0.010 |
Uric acid (umol/L) | 372.00 ± 79.12 | 0.002 | 358.30 ± 113.98 | 0.045 | 382.50 ± 82.38 | 0.035 |
iPTH (pg/mL) | 321.20 ± 180.91 | 0.044 | 306.3 ± 138.85 | 0.014 | 305.3 ± 159.74 | 0.017 |
Electrolytes | ||||||
Serum potassium (mmol/L) | 4.22 ± 0.63 | 0.005 | 4.15 ± 0.46 | 0.029 | 4.39 ± 0.59 | 0.210 |
Serum calcium (mmol/L) | 2.25 ± 0.27 | 0.000 | 2.41 ± 0.23 | 0.000 | 2.30 ± 0.17 | 0.002 |
Serum phosphorus (mmol/L) | 1.58 ± 0.39 | 0.006 | 1.42 ± 0.40 | 0.008 | 1.46 ± 0.43 | 0.007 |
Serum sodium (mmol/L) | 142.10 ± 3.15 | 0.011 | 143.70 ± 2.77 | 0.001 | 142.30 ± 2.83 | 0.209 |
CO2-CP (mmol/L) | 25.37 ± 2.68 | 0.000 | 24.66 ± 2.50 | 0.002 | 25.52 ± 3.10 | 0.001 |
Nutritional indicators | ||||||
Albumin (g/L) | 38.12 ± 6.05 | 0.042 | 38.75 ± 3.97 | 0.003 | 37.88 ± 3.33 | 0.000 |
Pre-albumin (mg/L) | 375.40 ± 95.85 | 0.001 | 361.80 ± 59.67 | 0.000 | 339.40 ± 105.90 | 0.056 |
Total protein (g/L) | 67.96 ± 7.41 | 0.213 | 70.64 ± 7.27 | 0.065 | 68.50 ± 5.86 | 0.043 |
Others | ||||||
FPG (mmol/L) | 6.25 ± 1.87 | 0.111 | 7.34 ± 3.38 | 0.035 | 6.91 ± 2.25 | 0.009 |
Hemoglobin (g/L) | 107.30 ± 15.62 | 0.000 | 112.10 ± 11.94 | 0.000 | 110.20 ± 18.98 | 0.000 |
GFR (mL/min/1.73 m2)# | 4.08 ± 2.03 | 0.003 | 4.08 ± 1.70 | 0.005 | 5.26 ± 2.37 | 0.114 |
Urine volume (mL) | 1190.00 ± 531.33 | 0.153 | 1308.00 ± 494.24 | 0.594 | 1376.00 ± 420.60 | 0.181 |
APD group (n = 42) | APD–CAPD group (n = 28) | CAPD group (n = 26) | P value | |
---|---|---|---|---|
Toxins | ||||
Blood urea nitrogen (mmol/L) | − 10.13 ± 7.98 | − 8.15 ± 10.45 | − 8.65 ± 7.09 | 0.689 |
Creatinine (umol/L) | − 172.50 ± 100.23 | − 195.60 ± 142.75 | − 159.90 ± 177.34 | 0.731 |
Uric acid (umol/L) | − 61.77 ± 81.87 | − 47.13 ± 99.23 | − 50.84 ± 74.94 | 0.817 |
iPTH (pg/ml) | − 97.73 ± 159.48 | − 141.40 ± 82.40 | − 140.70 ± 124.94 | 0.409 |
Electrolytes | ||||
Serum potassium (mmol/L) | − 0.53 ± 0.93 | − 0.34 ± 0.87 | 0.01 ± 0.65 | 0.059 |
Serum calcium (mmol/L) | 0.26 ± 0.24 | 0.30 ± 0.26 | 0.19 ± 0.31 | 0.434 |
Serum phosphorus (mmol/L) | − 0.59 ± 0.51 | − 0.73 ± 0.63 | − 0.60 ± 0.70 | 0.728 |
Serum sodium (mmol/L) | 1.71 ± 3.41 | 3.30 ± 5.14 | 1.32 ± 4.78 | 0.343 |
CO2-CP (mmol/L) | 2.57 ± 3.64 | 2.49 ± 2.66 | 3.12 ± 4.50 | 0.823 |
Nutritional indicators | ||||
Albumin (g/L) | 3.37 ± 4.54 | 4.21 ± 4.11 | 4.89 ± 4.50 | 0.443 |
Pre-albumin (mg/L) | 62.33 ± 97.06 | 45.44 ± 81.62 | 43.00 ± 74.10 | 0.669 |
Total protein (g/L) | 3.27 ± 7.41 | 6.02 ± 4.32 | 6.38 ± 6.59 | 0.169 |
Others | ||||
Fasting plasma glucose (mmol/L) | 0.45 ± 2.67 | 1.72 ± 2.30 | 1.42 ± 1.77 | 0.142 |
Hemoglobin (g/L) | 26.26 ± 14.33 | 32.47 ± 14.08 | 28.43 ± 21.58 | 0.475 |
GFR (mL/min/1.73 m2) | − 1.63 ± 1.63 | − 1.44 ± 1.60 | − 1.14 ± 2.65 | 0.679 |
Urine volume (mL) | − 161.70 ± 528.45 | − 72.92 ± 469.64 | − 195.50 ± 550.74 | 0.706 |
Peritoneal equilibration tests for three PD modes
APD group | APD–CAPD group | CAPD group |
P
| |
---|---|---|---|---|
High transport/low transport (n/n)a | 24/18 | 15/13 | 15/11 | 0.943 |