Background
Methods
Model configuration and validation
Knowledge-based IMRT planning
Dosimetric assessment and statistical comparison
Results
Model validation on similar cases
Mean | SD | 95 % Confidence intervals | △(%) |
P
| |||
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
HI_PGTV
| Original | 0.06 | 0.01 | 0.05 | 0.07 | 0.01 | 0.15* |
RP-VMAT | 0.05 | 0.01 | 0.05 | 0.06 | |||
HI_PTV
| Original | 0.26 | 0.01 | 0.25 | 0.27 | 0 | 0.62* |
RP-VMAT | 0.26 | 0.01 | 0.25 | 0.27 | |||
CI_PGTV
| Original | 1.01 | 0.04 | 0.98 | 1.04 | 0.01 | 0.11 |
RP-VMAT | 1.00 | 0.04 | 0.97 | 1.03 | |||
CI_PTV
| Original | 1.03 | 0.02 | 1.02 | 1.05 | 0.01 | 0.05* |
RP-VMAT | 1.02 | 0.02 | 1.01 | 1.04 | |||
Dmax
| Original | 53.93 | 0.35 | 53.69 | 54.18 | 0.36 (0.67 %) | 0.07* |
RP-VMAT | 53.57 | 0.50 | 53.22 | 53.93 | |||
D2 %
| Original | 53.37 | 0.37 | 53.10 | 53.63 | 0.34 (0.64 %) | 0.15* |
RP-VMAT | 53.03 | 0.46 | 52.70 | 53.36 | |||
D50 %_UB
| Original | 28.90 | 5.31 | 25.10 | 32.69 | 5.39 (18.65 %) | 0.01 |
RP-VMAT | 23.51 | 3.26 | 21.18 | 25.84 | |||
D50 %_FH
| Original | 16.30 | 1.66 | 15.11 | 17.48 | 2.30 (14.11 %) | 0.01 |
RP-VMAT | 14.00 | 0.92 | 13.34 | 14.65 | |||
Dmean_UB
| Original | 30.01 | 4.52 | 26.77 | 33.24 | 4.51 (15.03 %) | 0.01 |
RP-VMAT | 25.50 | 1.54 | 24.40 | 26.60 | |||
Dmean_FH
| Original | 17.18 | 1.80 | 15.90 | 18.47 | 1.85 (10.77 %) | 0.01 |
RP-VMAT | 15.33 | 0.68 | 14.85 | 15.82 | |||
MUs | Original | 412 | 41 | 383 | 441 | 18 (4.37 %) | 0.14 |
RP-VMAT | 430 | 23 | 413 | 447 |
Original vs. RP-IMRT plans
Mean | SD | 95 % Confidence intervals | △(%) |
P
| |||
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
HI_PGTV
| Original | 0.04 | 0.01 | 0.04 | 0.05 | 0.01 | 0.04 |
RP-IMRT | 0.05 | 0.01 | 0.04 | 0.05 | |||
HI_PTV
| Original | 0.25 | 0.01 | 0.24 | 0.25 | 0.01 | 0.01* |
RP-IMRT | 0.26 | 0.01 | 0.25 | 0.26 | |||
CI_PGTV
| Original | 1.03 | 0.05 | 1.01 | 1.05 | 0.01 | 0.61 |
RP-IMRT | 1.02 | 0.05 | 1.00 | 1.04 | |||
CI_PTV
| Original | 1.01 | 0.02 | 1.00 | 1.02 | 0.17 | <0.01* |
RP-IMRT | 1.18 | 0.05 | 1.16 | 1.20 | |||
Dmax
| Original | 52.95 | 0.44 | 52.78 | 53.11 | 1.51 (2.85 %) | <0.01 |
RP-IMRT | 54.46 | 1.52 | 53.89 | 55.02 | |||
D2 %
| Original | 52.61 | 0.43 | 52.44 | 52.77 | 0.15 (0.29 %) | 0.09 |
RP-IMRT | 52.76 | 0.51 | 52.57 | 52.95 | |||
D50 %_UB
| Original | 33.85 | 2.96 | 32.74 | 34.95 | 8.76 (25.88 %) | <0.01* |
RP-IMRT | 25.09 | 1.32 | 24.59 | 25.58 | |||
D50 %_FH
| Original | 15.65 | 3.33 | 14.41 | 16.90 | 1.92 (12.27 %) | <0.01* |
RP-IMRT | 13.73 | 1.43 | 13.19 | 14.26 | |||
Dmean_UB
| Original | 33.99 | 2.77 | 32.95 | 35.02 | 7.74 (22.77 %) | <0.01 |
RP-IMRT | 26.25 | 1.22 | 25.79 | 26.70 | |||
Dmean_FH
| Original | 16.26 | 2.74 | 15.24 | 17.28 | 1.64 (10.09) | <0.01 |
RP-IMRT | 14.62 | 1.10 | 14.21 | 15.04 | |||
MUs | Original | 805 | 82 | 774 | 836 | 394 (48.94 %) | <0.01* |
RP-IMRT | 1199 | 80 | 1169 | 1229 |
Supine vs. prone setup orientations
Original | RapidPlan | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | 95 % CIs | △(%) |
P
| Mean | SD | 95 % CIs | △(%) |
P
| ||
HI_PGTV
| S. | 0.04 | 0.01 | 0.04 ~ 0.05 | 0 | 0.66* | 0.05 | 0.01 | 0.04 ~ 0.05 | 0 | 0.97 |
P. | 0.04 | 0.01 | 0.04 ~ 0.05 | 0.05 | 0.01 | 0.04 ~ 0.06 | |||||
HI_PTV
| S. | 0.24 | 0.01 | 0.24 ~ 0.25 | 0.01 | 0.24* | 0.25 | 0.01 | 0.25 ~ 0.26 | 0.01 | 0.22* |
P. | 0.25 | 0.01 | 0.24 ~ 0.25 | 0.26 | 0.02 | 0.25 ~ 0.26 | |||||
CI_PGTV
| S. | 1.03 | 0.07 | 0.99 ~ 1.09 | 0.01 | 0.73 | 1.01 | 0.06 | 0.97 ~ 1.05 | 0.01 | 0.48 |
P. | 1.02 | 0.05 | 1.00 ~ 1.04 | 1.02 | 0.05 | 0.99 ~ 1.04 | |||||
CI_PTV
| S. | 1.02 | 0.02 | 1.00 ~ 1.04 | 0.01 | 0.16 | 1.19 | 0.07 | 1.14 ~ 1.24 | 0.01 | 0.56* |
P. | 1.01 | 0.02 | 1.00 ~ 1.02 | 1.18 | 0.05 | 1.16 ~ 1.20 | |||||
Dmax
| S. | 52.93 | 0.45 | 52.61 ~ 53.25 | 0.03 (0.06 %) | 0.98 | 54.73 | 1.67 | 53.53 ~ 55.93 | 0.41 (0.75 %) | 0.48 |
P. | 52.96 | 0.45 | 52.75 ~ 53.17 | 54.32 | 1.46 | 53.64 ~ 55.00 | |||||
D2 %
| S. | 52.56 | 0.41 | 52.26 ~ 52.85 | 0.07 (0.13 %) | 0.68* | 52.71 | 0.24 | 52.53 ~ 52.88 | 0.08 (0.15 %) | 0.86 |
P. | 52.63 | 0.45 | 52.42 ~ 52.84 | 52.79 | 0.61 | 52.50 ~ 53.07 | |||||
D50 %_UB
| S. | 34.13 | 2.73 | 32.16 ~ 36.06 | 0.41 (1.20 %) | 0.74* | 25.12 | 0.84 | 24.52 ~ 25.72 | 0.05 (0.20 %) | 0.93* |
P. | 33.72 | 3.12 | 32.26 ~ 35.18 | 25.07 | 1.53 | 24.36 ~ 25.79 | |||||
D50 %_FH
| S. | 18.89 | 2.69 | 16.96 ~ 20.81 | 4.85 (25.67 %) | <0.01* | 14.67 | 1.80 | 13.38 ~ 15.95 | 1.41 (9.61 %) | 0.01* |
P. | 14.04 | 2.28 | 12.97 ~ 15.11 | 13.26 | 0.94 | 12.82 ~ 13.70 | |||||
Dmean_UB
| S. | 34.25 | 2.90 | 32.17 ~ 36.32 | 0.39 (1.14 %) | 0.72* | 26.19 | 0.97 | 25.50 ~ 26.89 | 0.08 (0.31 %) | 0.87* |
P. | 33.86 | 2.77 | 32.56 ~ 35.15 | 26.27 | 1.36 | 25.64 ~ 26.91 | |||||
Dmean_FH
| S. | 19.23 | 2.41 | 17.51 ~ 20.96 | 4.45 (23.14 %) | <0.01 | 15.41 | 1.07 | 14.64 ~ 16.17 | 1.18 (7.66 %) | <0.01* |
P. | 14.78 | 1.31 | 14.17 ~ 15.39 | 14.23 | 0.91 | 13.81 ~ 14.66 |