Introduction
Methods
Environmental exposure
Study population
Registers
Haematological malignancies
Assessment of occupational exposure
Statistics
Results
Variable, n (%) | School cohort | Reference cohort | p value | ||
---|---|---|---|---|---|
Sex | 12,111 | (10.0) | 108,987 | (90.0) | |
Female | 6024 | (49.7) | 54,200 | (49.7) | |
Male | 6087 | (50.3) | 54,787 | (50.3) | 0.99 |
Age, median (range) | 62.4 | (13.0–76.0) | 62.1 | (12.0–76.0) | < 0.01 |
Follow-up, median (range) | 49.4 | (1.2–63.4) | 49.0 | (0.1–63.4) | < 0.01 |
Born in Denmarka | 11,834 | (99.1) | 95,098 | (87.8) | < 0.01 |
Death | 1898 | (15.7) | 15,081 | (13.8) | < 0.01 |
Overall haematological malignancies | 110 | (0.9) | 1,015 | (0.9) | 0.80 |
Hodgkin lymphoma (C81) | 14 | (0.1) | 96 | (0.1) | 0.34 |
Non-Hodgkin lymphoma and malignant immunoproliferative disease (C82–85, C88.3–88.9) | 45 | (0.4) | 450 | (0.4) | 0.50 |
Multiple myeloma (C90, C88.0–88.2) | 8 | (0.1) | 152 | (0.1) | 0.04 |
Lymphatic leukaemia (C91) | 18 | (0.2) | 166 | (0.2) | 0.92 |
Myeloid leukaemia (C92) | 19 | (0.2) | 134 | (0.1) | 0.32 |
Monocytic leukaemia (C93) | 3 | (0.02) | 6 | (0.01) | 0.02 |
Other and unspecified leukaemia (C94–95) | 1 | (0.01) | 8 | (0.01) | 0.91 |
Other and unspecified cancer in lymphatic and haematopoietic tissue (C96) | 2 | (0.02) | 3 | (< 0.01) | 0.03 |
Wage earning years, median (range)b | 27.9 | (0.02–58.2) | 28.7 | (0.02–78.2) | < 0.01 |
Occupational asbestos exposureb | |||||
No | 9777 | (82.7) | 91,501 | (89.4) | |
Yes; JEM1 | 2048 | (17.3) | 10,888 | (10.6) | < 0.01 |
JEM2b | p value | |||
---|---|---|---|---|
Unexposed | Exposed | Total | ||
JEM1a | ||||
Unexposed | 96,856 | 4422 | 101,278 | |
Exposed | 4599 | 8337 | 12,936 | |
Total | 101,455 | 12,759 | 114,214 | 0.06 |
JEM2 > 10 | ||||
---|---|---|---|---|
Unexposed | Exposed | Total | ||
JEM1 > 10 | ||||
Unexposed | 111,788 | 448 | 112,236 | |
Exposed | 1287 | 691 | 1978 | |
Total | 113,075 | 1139 | 114,214 | < 0.001 |
JEM2 > 15 | ||||
---|---|---|---|---|
Unexposed | Exposed | Total | ||
JEM1 > 15 | ||||
Unexposed | 112,661 | 252 | 112,913 | |
Exposed | 960 | 341 | 1301 | |
Total | 113,621 | 593 | 114,214 | < 0.001 |
JEM1 | JEM1 > 10 year | JEM1 > 15 year | |||||||
---|---|---|---|---|---|---|---|---|---|
Cases | HR | (95% CI) | Cases | HR | (95% CI) | Cases | HR | (95% CI) | |
Haematological malignancy | |||||||||
Population | |||||||||
Reference | 989 | 1 | 989 | 1 | 989 | 1 | |||
School | 106 | 0.92 | (0.75–1.13) | 106 | 0.92 | (0.75–1.12) | 106 | 0.92 | (0.75–1.12) |
Sex | |||||||||
Female | 430 | 1 | 430 | 1 | 430 | 1 | |||
Male | 665 | 1.58 | (1.39–1.79) | 665 | 1.56 | (1.38–1.76) | 665 | 1.57 | (1.39–1.77) |
Asbestos exposure | |||||||||
No | 935 | 1 | 1,061 | 1 | 1,073 | 1 | |||
Yes | 160 | 0.98 | (0.82–1.17) | 34 | 1.21 | (0.86–1.71) | 22 | 1.16 | (0.76–1.77) |
Combined lymphoma | |||||||||
Population | |||||||||
Reference | 683 | 1 | 683 | 1 | 683 | 1 | |||
School | 66 | 0.83 | (0.65–1.07) | 66 | 0.83 | (0.64–1.07) | 66 | 0.83 | (0.64–1.07) |
Sex | |||||||||
Female | 288 | 1 | 288 | 1 | 288 | 1 | |||
Male | 461 | 1.65 | (1.42–1.92) | 461 | 1.63 | (1.41–1.89) | 461 | 1.63 | (1.40–1.89) |
Asbestos exposure | |||||||||
No | 643 | 1 | 730 | 1 | 736 | 1 | |||
Yes | 106 | 0.94 | (0.76–1.16) | 19 | 0.98 | (0.62–1.55) | 13 | 0.99 | (0.57–1.72) |
Combined leukaemia | |||||||||
Population | |||||||||
Reference | 303 | 1 | 303 | 1 | 303 | 1 | |||
School | 38 | 1.07 | (0.76–1.50) | 38 | 1.06 | (0.76–1.49) | 38 | 1.07 | (0.76–1.50) |
Sex | |||||||||
Female | 140 | 1 | 140 | 1 | 140 | 1 | |||
Male | 201 | 1.44 | (1.15–1.80) | 201 | 1.42 | (1.14–1.77) | 201 | 1.44 | (1.16–1.79) |
Asbestos exposure | |||||||||
No | 288 | 1 | 326 | 1 | 332 | 1 | |||
Yes | 53 | 1.07 | (0.79–1.46) | 15 | 1.78 | (1.05–3.00) | 9 | 1.56 | (0.80–3.04) |
JEM2 | JEM2 > 10 year | JEM2 > 15 year | |||||||
---|---|---|---|---|---|---|---|---|---|
Cases | HR | (95% CI) | Cases | HR | (95% CI) | Cases | HR | (95% CI) | |
Haematological malignancy | |||||||||
Population | |||||||||
Reference | 989 | 1 | 989 | 1 | 989 | 1 | |||
School | 106 | 0.92 | (0.75–1.12) | 106 | 0.91 | (0.75–1.11) | 106 | 0.91 | (0.75–1.12) |
Sex | |||||||||
Female | 430 | 1 | 430 | 1 | 430 | 1 | |||
Male | 665 | 1.56 | (1.37–1.77) | 665 | 1.56 | (1.38–1.76) | 665 | 1.56 | (1.38–1.76) |
Asbestos exposure | |||||||||
No | 917 | 1 | 1,068 | 1 | 1,078 | 1 | |||
Yes | 178 | 1.05 | (0.88–1.24) | 27 | 1.47 | (1.00–2.16) | 17 | 1.69 | (1.04–2.73) |
Combined lymphoma | |||||||||
Population | |||||||||
Reference | 683 | 1 | 683 | 1 | 683 | 1 | |||
School | 66 | 0.83 | (0.64–1.07) | 66 | 0.83 | (0.64–1.07) | 66 | 0.83 | (0.64–1.07) |
Sex | |||||||||
Female | 288 | 1 | 288 | 1 | 288 | 1 | |||
Male | 461 | 1.63 | (1.40–1.90) | 461 | 1.62 | (1.40–1.88) | 461 | 1.62 | (1.40–1.88) |
Asbestos exposure | |||||||||
No | 632 | 1 | 734 | 1 | 740 | 1 | |||
Yes | 117 | 0.99 | (0.80–1.22) | 15 | 1.18 | (0.71–1.98) | 9 | 1.30 | (0.67–2.51) |
Combined leukaemia | |||||||||
Population | |||||||||
Reference | 303 | 1 | 303 | 1 | 303 | 1 | |||
School | 38 | 1.06 | (0.76–1.49) | 38 | 1.05 | (0.75–1.48) | 38 | 1.06 | (0.76–1.48) |
Sex | |||||||||
Female | 140 | 1 | 140 | 1 | 140 | 1 | |||
Male | 201 | 1.41 | (1.12–1.77) | 201 | 1.42 | (1.14–1.77) | 201 | 1.43 | (1.15–1.78) |
Asbestos exposure | |||||||||
No | 281 | 1 | 329 | 1 | 333 | 1 | |||
Yes | 60 | 1.18 | (0.88–1.59) | 12 | 2.14 | (1.19–3.84) | 8 | 2.59 | (1.28–5.26) |