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Quality of Life Research

Erschienen in:

26.09.2016

Assessment of health-related quality of life, mental health status and psychological distress based on the type of pharmacotherapy used among patients with depression

verfasst von: Drishti Shah, Varun Vaidya, Amit Patel, Mary Borovicka, Monica-Holiday Goodman

Erschienen in: Quality of Life Research | Ausgabe 4/2017

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Abstract

Purpose

Effectiveness of antidepressants is generally comparable between and within classes. However, real-world studies on antidepressant treatment and its consequences on the overall quality of life and mental health of individuals are limited. The purpose of this study was to examine the association of specific class of antidepressants with the health-related quality of life, psychological distress and self-reported mental health of individuals suffering from depression who are on monotherapy.

Methods

This retrospective, longitudinal study included individuals with depression who were on antidepressant monotherapy, using data from 2008 to 2011 Medical Expenditure Panel Survey (MEPS). Changes in health-related quality of life, self-reported mental health and psychological distress over a year’s time were observed. A multinomial logistic regression model was built to examine the association between the class of antidepressant medications and the dependent variables.

Results

A total of 688 adults met the study inclusion criteria. No significant difference was observed in the change in Physical Component Summary (PCS), self-reported mental health and psychological distress based on the class of antidepressants. However, individuals on serotonin–norepinephrine reuptake inhibitors (SNRIs) (OR 0.337, 95 % CI 0.155–0.730) were significantly less likely to show improvement on Mental Component Summary (MCS) scores as compared to those on selective serotonin reuptake inhibitors (SSRIs).

Conclusions

The study findings suggest that practitioners should be aware of the differences in the health-related quality of life of those taking SSRIs versus other classes of antidepressants. Further research needs to be done to determine the reason for SSRIs to show greater improvement on mental health as compared to SNRIs.

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Titel: Assessment of health-related quality of life, mental health status and psychological distress based on the type of pharmacotherapy used among patients with depression
verfasst von: Drishti Shah
Varun Vaidya
Amit Patel
Mary Borovicka
Monica-Holiday Goodman
Publikationsdatum: 26.09.2016
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 4/2017
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-016-1417-0

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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