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01.03.2013 | Original paper

Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case–control study (the Bellvitge Colorectal Cancer Study)

verfasst von: Raul Zamora-Ros, Carla Not, Elisabeth Guinó, Leila Luján-Barroso, Raul M. García, Sebastiano Biondo, Ramón Salazar, Victor Moreno

Erschienen in: Cancer Causes & Control | Ausgabe 3/2013

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Abstract

Background

Flavonoid-rich foods, such as fruits, vegetables, and tea, may have a protective effect upon colorectal cancer. However, current epidemiological evidence for a protective effect of flavonoid intake upon colorectal cancer is promising but not conclusive.

Objective

To examine the relation between dietary flavonoid and lignan intakes and the risk of colorectal cancer within a Spanish population.

Design

Data from the Bellvitge Colorectal Cancer Study, a case–control study (424 cases with incident colorectal cancer and 401 hospital-based controls), were used. A reproducible and validated food frequency questionnaire was administered in personal interviews. An ad hoc food composition database on flavonoids and lignans was compiled, mainly using data from the US Department of Agriculture and Phenol-Explorer databases. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using unconditional logistic regression models.

Results

An inverse association was found between intake of total flavonoids (OR, 0.59; 95 % CI, 0.35–0.99 for the highest vs. the lowest quartile; p for trend = 0.04), lignans (OR, 0.59; 95 % CI, 0.34–0.99; p for trend = 0.03), and some individual flavonoid subgroups (flavones, proanthocyanidins) and the risk of colorectal cancer. Separate analyses by cancer site showed similar results.

Conclusions

Intake of total dietary flavonoids (particularly certain flavonoid subgroups) and lignans was inversely associated with colorectal cancer risk in a Spanish population.

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Titel: Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case–control study (the Bellvitge Colorectal Cancer Study)
verfasst von: Raul Zamora-Ros
Carla Not
Elisabeth Guinó
Leila Luján-Barroso
Raul M. García
Sebastiano Biondo
Ramón Salazar
Victor Moreno
Publikationsdatum: 01.03.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 3/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9992-z

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Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case–control study (the Bellvitge Colorectal Cancer Study)