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International Archives of Occupational and Environmental Health

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30.10.2018 | Original Article

Association between maternal blood cadmium and lead concentrations and gestational diabetes mellitus in the Japan Environment and Children’s Study

verfasst von: Tomoko Oguri, Takashi Ebara, Shoji F. Nakayama, Mayumi Sugiura-Ogasawara, Michihiro Kamijima, The Japan Environment and Children’s Study Group

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 2/2019

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Abstract

Purpose

To examine the association between elevated blood cadmium (Cd) and lead (Pb) concentrations and increased risk of gestational diabetes mellitus (GDM).

Methods

This cross-sectional study included pregnant women (n = 16,955) enrolled in the Japan Environment and Children’s Study. Concentrations of Cd and Pb in blood samples collected at 22–28 weeks’ gestation were measured by inductively coupled plasma mass spectrometry. GDM was diagnosed according to the 2011 Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists criteria. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression analysis.

Results

Blood Cd and Pb concentrations were slightly higher among women with GDM than among those without GDM; however, these differences were not statistically significant. Elevated blood Cd and Pb concentrations were not associated with increased GDM risk in the nulliparous group (Cd OR 0.76; 95% CI 0.28–2.08 for high vs low category; Pb OR 2.51; 95% CI 0.72–8.72) or the parous group (Cd OR 0.64; 95% CI 0.29–1.44; Pb OR 0.31; 95% CI 0.04–2.29).

Conclusions

This study demonstrates that Cd and Pb exposure, in the range of blood levels observed, has no significant relationship with the development of GDM. Further prospective studies would be valuable to confirm these findings.

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Titel: Association between maternal blood cadmium and lead concentrations and gestational diabetes mellitus in the Japan Environment and Children’s Study
verfasst von: Tomoko Oguri
Takashi Ebara
Shoji F. Nakayama
Mayumi Sugiura-Ogasawara
Michihiro Kamijima
The Japan Environment and Children’s Study Group
Publikationsdatum: 30.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 2/2019
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-018-1367-7

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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