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Osteoporosis International

Erschienen in:

04.07.2019 | Original Article

Association between serum uric acid and bone health in adolescents

verfasst von: F. Karimi, M. H. Dabbaghmanesh, G. R. Omrani

Erschienen in: Osteoporosis International | Ausgabe 10/2019

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Abstract

Summary

Previous studies are suggestive of the protective role of uric acid on bone in the middle-aged and elderly. Whether this association exists in younger individuals has not been examined. This investigation showed a significant positive association between serum uric acid and bone parameters among Iranian adolescents.

Introduction

Uric acid (UA) might be linked to bone health, but it is unclear whether its effects on bone are limited to certain population subgroups. This study is aimed at investigating the correlation between serum uric acid levels and bone mineral density (BMD) in Iranian adolescents.

Methods

This cross-sectional study was conducted on 413 (221 girls and 192 boys) Iranian adolescents aged 9–19 years. An analysis of anthropometric, biochemical parameters and bone density was performed on the participants. Measurements included serum uric acid, calcium, phosphorus, alkaline phosphatase, albumin, and vitamin D. They were divided according to their serum UA into the low UA group who had UA ≤ 6 mg/dL and the high UA group with UA > 6 mg/dL. BMD and bone mineral content (BMC) were measured in the total body, lumbar spine, and left femoral neck, using dual energy X-ray absorptiometry (DXA), and bone mineral apparent density (BMAD) was calculated.

Results

A Pearson correlation analysis revealed a significant correlation between UA and bone parameters. In multiple regression analyses adjusted for potential confounders, serum UA was proven to be associated with BMD and BMC at all sites. There was no association between UA, serum calcium, and vitamin D concentrations.

Conclusion

Our study, as the first research on adolescents, demonstrated a higher bone density in those who had higher UA levels.

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Titel: Association between serum uric acid and bone health in adolescents
verfasst von: F. Karimi
M. H. Dabbaghmanesh
G. R. Omrani
Publikationsdatum: 04.07.2019
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 10/2019
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-019-05072-w

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Summary

Introduction

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