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10.11.2022 | Meta- Analysis

Association between the history of abortion and gestational diabetes mellitus: A meta-analysis

verfasst von: Hao Wang, Xianwei Guo, Qiuxia Song, Wanying Su, Muzi Meng, Chenyu Sun, Ning Li, Qiwei Liang, Guangbo Qu, Mingming Liang, Xiuxiu Ding, Yehuan Sun

Erschienen in: Endocrine | Ausgabe 1/2023

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Abstract

Purpose

Gestational diabetes mellitus (GDM) is a common metabolic disease in pregnant women. The purpose of this study was to determine whether a history of abortion increases the risk of GDM by meta-analysis.

Methods

A comprehensive literature search was conducted in nine databases of studies on the association between abortion history and GDM up to April 12, 2022. Fixed- or random-effects models were used to estimate the pooled odds ratio (OR) and 95% CI. The I square value (I²) was used to assess heterogeneity. Possible sources of heterogeneity were explored by conducting subgroup analysis and meta-regression. A sensitivity analysis was also performed for this meta-analysis. Publication bias was assessed by funnel plots and Egger’s tests.

Results

Thirty-one studies enrolling 311,900 subjects were included in this meta-analysis. The risk of GDM was higher in women who experienced abortion than in those who did not (OR = 1.41 95% CI: 1.28–1.55, I² = 66.8%). The risk of GDM increased with an increasing number of abortions (1 time: OR = 1.67, 95% CI = 1.26–2.22; 2 times: OR = 2.10, 95% CI = 1.26–3.49; ≥3 times: OR = 2.49, 95% CI = 1.24–5.01). Both spontaneous abortion (OR = 1.52, 95% CI = 1.30–1.78) and induced abortion (OR = 1.07, 95% CI = 1.03–1.11) were associated with an increased risk of GDM.

Conclusions

A history of abortion was associated with an increased risk of GDM in pregnant women, which may be a risk factor for predicting GDM.

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Titel: Association between the history of abortion and gestational diabetes mellitus: A meta-analysis
verfasst von: Hao Wang
Xianwei Guo
Qiuxia Song
Wanying Su
Muzi Meng
Chenyu Sun
Ning Li
Qiwei Liang
Guangbo Qu
Mingming Liang
Xiuxiu Ding
Yehuan Sun
Publikationsdatum: 10.11.2022
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2023
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-022-03246-x

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Association between the history of abortion and gestational diabetes mellitus: A meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

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