Introduction
Methods
Results
Characteristics | All participants | Without diabetes | Prevalent cases | Incident cases | p value |
---|---|---|---|---|---|
N
| 6,362 | 5,156 | 661 | 545 | |
Age (years) | 69.4 ± 9.1 | 69 ± 9.1 | 73.5 ± 9.2 | 68.4 ± 7.9 | <0.001a,b
|
Men (%) | 40.6 | 40.4 | 39.5 | 44 | NS |
BMI (kg/m2) | 26.3 ± 3.7 | 26.0 ± 3.6 | 26.8 ± 4.1 | 28.1 ± 3.7 | <0.001a,b,c
|
Total cholesterol (mmol/l) | 6.6 ± 1.2 | 6.6 ± 1.2 | 6.5 ± 1.2 | 6.6 ± 1.2 | NS |
Triacylglycerol (mmol/l) | 1.53 ± 0.01 | 1.47 ± 0.01 | 1.83 ± 0.07 | 1.89 ± 0.05 | <0.001a,c
|
HDL-cholesterol (mmol/l) | 1.34 ± 0.37 | 1.37 ± 0.37 | 1.25 ± 0.37 | 1.25 ± 0.34 | <0.001b,c
|
Age at diagnosis (years) | NA | NA | 68.6 ± 0.50 | 74.8 ± 0.34 | <0.001b
|
Variants | RS1 HR | RS1 OR | Replication cohort | Overall | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polymorphisms per BMI | Genotype | Incident diabetesa
| 95% CI | p trend | Prevalent diabetesa
| 95% CI | p trend | ORb
| 95% CI | p trend | p valuec |
BMI ≤ 26 kg/m2
| |||||||||||
− 482C > T | CC | 1.0 | 1.0 | 1.0 | |||||||
CT | 1.35 | (0.96–1.89) | 1.47 | (1.13–1.92) | 1.06 | (0.81–1.38) | |||||
TT | 1.68 | (0.91–3.1) | 0.03 | 1.40 | (0.83–2.35) | 0.009 | 1.99 | (1.25–3.16) | 0.03 | 1.1 × 10-4
| |
− 455T > C | TT | 1.0 | 1.0 | 1.0 | |||||||
TC | 1.27 | (0.89–1.8) | 1.65 | (1.24–2.20) | 0.86 | (0.66–1.13) | |||||
CC | 1.39 | (0.85–2.28) | 0.1 | 1.40 | (0.92–2.13) | 0.01 | 1.09 | (0.74–1.62) | 0.9 | 0.04 | |
BMI >26 kg/m2
| |||||||||||
−482C > T | CC | 1.0 | 1.0 | 1.0 | |||||||
CT | 1.04 | (0.84–1.28) | 0.85 | (0.66–1.10) | 1.04 | (0.88–1.23) | |||||
TT | 0.56 | (0.32–0.98) | 0.3 | 0.84 | (0.51–1.39) | 0.22 | 1.47 | (1.08–1.99) | 0.05 | 0.73 | |
−455T > C | TT | 1.0 | 1.0 | 1.0 | |||||||
TC | 0.88 | (0.71–1.1) | 0.98 | (0.76–1.25) | 0.90 | (0.76–1.06) | |||||
CC | 0.70 | (0.49–0.998) | 0.04 | 0.71 | (0.48–1.06) | 0.16 | 0.79 | (0.62–1.02) | 0.05 | 0.003 |
Characteristics | All participants a
| Controls | Cases | p value |
---|---|---|---|---|
n
| 4,134 | 2,292 | 1,817 | |
Age (years) | 65.5 ± 9.0 | 64.4 ± 7.8 | 66.8 ± 10.1 | <0.001 |
Men (%) | 48.4 | 44.3 | 53.7 | <0.001 |
BMI (kg/m2) | 28.4 ± 4.9 | 26.9 ± 3.9 | 30.4 ± 5.3 | <0.001 |
Polymorphism per BMI | Genotype | ORa
| 95% CI | p value for trend |
---|---|---|---|---|
BMI ≤ 26 kg/m2
b
| ||||
−482C > T | CC | Reference | ||
CT | 1.49 | (0.89–2.49) | ||
TT | 1.66 | (0.68–4.00) | 0.11 | |
−455T > C | TT | Reference | ||
TC | 1.71 | (0.95–3.08) | ||
CC | 1.64 | (0.74–3.62) | 0.13 | |
BMI >26 kg/m2c
| ||||
−482C > T | CC | Reference | ||
CT | 0.94 | (0.63–1.41) | ||
TT | 1.26 | (0.53–3.03) | 0.92 | |
−455T > C | TT | Reference | ||
TC | 0.83 | (0.56–1.25) | ||
CC | 0.78 | (0.40–1.55) | 0.34 |