Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Das Thema chronische Unterbauch- und Viszeralschmerzen wird im Live-Webinar am 7. Mai von 17.30 bis 19 Uhr aus internistischer, gynäkologischer und psychologisch-neurowissenschaftlicher Perspektive beleuchtet. Besprochen werden krankheitsbedingte Ursachen, Mechanismen der kognitiven Schmerzmodulation sowie mögliche Therapieoptionen. Die Fortbildung ist mit 2 CME-Punkten zertifiziert. Melden Sie sich jetzt an!
Erweiterte Suche
Anmelden
nach oben
Endocrine
Erschienen in: Endocrine 3/2021

17.07.2021 | Original Article

Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men

verfasst von: Li Fu, Kevin C. J. Yuen, Aye Nyein Tint, Andrew R. Hoffman, Ariff T. Bongso, Kok Onn Lee

Erschienen in: Endocrine | Ausgabe 3/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Previous studies have suggested the involvement of serum insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the regulation of the female reproductive system. Little is known of these peptides in the seminal plasma (SP) of men and their potential effects on fertility. We assessed SP levels of these peptides in infertile men with low sperm motility (asthenozoospermic; AZ) and low sperm counts (oligozoospermic; OZ), its effects on in vivo sperm motility, and whether there is a correlation with aging.

Methods

Twenty-eight infertile men (AZ; n = 18 and OZ; n = 10) and 20 fertile normozoospermic (NZ) men were studied. Seminal plasma IGF-I, IGF-II, IGFBP-2, IGFBP-3, and prostate-specific antigen (PSA) levels were measured, and spermatozoa mRNA transcript patterns were examined.

Results

Asthenozoospermic men had higher SP IGF-I, IGF-II, IGFBP-2, and PSA levels than NZ and OZ men, whereas SP IGFBP-3 levels were similar between the three groups. Sperm count positively correlated with SP IGF-I, IGF-II, and IGFBP-2; sperm motility negatively correlated with SP IGF-II and IGFBP-2; and age correlated positively with SP IGF-II. The expression of IGF-I and IGF-II mRNA and mRNA receptors was detectable, but no variations in transcript levels were noted.

Conclusion

Decreased sperm motility, but not sperm count, in infertile AZ men is associated with increased SP IGF-I, IGF-II, IGFBP-2, and PSA levels. Changes in SP IGFs and their interactions with IGFBPs and IGF receptors, and PSA levels suggest a role of these SP peptides in modulating sperm motility and possibly prostate disease development in aging men.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
R. Abir, R. Garor, C. Felz, S. Nitke, H. Krissi et al. Growth hormone and its receptor in human ovaries from fetuses and adults. Fertil Steril 90, 1333–1339 (2008)PubMedCrossRef
2.
K.L. Hull, S. Harvey, Growth hormone and reproduction: a review of endocrine and autocrine/paracrine interactions. Int J Endocrinol 2014, 234014 (2014)PubMedPubMedCentralCrossRef
3.
A. Radicioni, E. Paris, F. Dondero, V. Bonifacio, A. Isidori, Recombinant-growth hormone (rec-hGH) therapy in infertile men with idiopathic oligozoospermia. Acta Eur Fertil 25, 311–317 (1994)PubMed
4.
K.O. Lee, S.C. Ng, P.S. Lee, A.T. Bongso, E.A. Taylor et al. Effect of growth hormone therapy in men with severe idiopathic oligozoospermia. Eur J Endocrinol 132, 159–162 (1995)PubMedCrossRef
5.
P. Ovesen, J.O. Jorgensen, J. Ingerslev, K.K. Ho, H. Orskov et al. Growth hormone treatment of subfertile males. Fertil Steril 66, 292–298 (1996)PubMedCrossRef
6.
B.H. Breier, M.H. Vickers, C.G. Gravance, P.J. Casey, Therapy with growth hormone: major prospects for the treatment of male subfertility? Endocr J 45(Suppl), S53–S60 (1998)PubMedCrossRef
7.
8.
9.
H.J. Glander, J. Kratzsch, C. Weisbrich, G. Birkenmeier, Insulin-like growth factor-I and alpha 2-macroglobulin in seminal plasma correlate with semen quality. Hum Reprod 11, 2454–2460 (1996)PubMedCrossRef
10.
S. Rajaram, D.J. Baylink, S. Mohan, Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18, 801–831 (1997)PubMed
11.
R.C. Baxter, Circulating binding proteins for the insulin like growth factors. Trends Endocrinol Metab 4, 91–96 (1993)PubMedCrossRef
12.
S.E. Gargosky, H.M. Pham, K.F. Wilson, F. Liu, L.C. Giudice et al. Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology 131, 3051–3060 (1992)PubMedCrossRef
13.
E. Ipsa, V.F. Cruzat, J.N. Kagize, J.L. Yovich, K.N. Keane, Growth hormone and insulin-like growth factor action in reproductive tissues. Front Endocrinol (Lausanne) 10, 777 (2019)CrossRef
14.
M. Simopoulou, A. Philippou, E. Maziotis, K. Sfakianoudis, N. Nitsos et al. Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1. Andrologia 50, e13048 (2018)PubMedCrossRef
15.
J.B. Colombo, R.K. Naz, Modulation of insulin-like growth factor-1 in the seminal plasma of infertile men. J Androl 20, 118–125 (1999)PubMed
16.
H.S. Lee, Y.S. Park, J.S. Lee, J.T. Seo, Serum and seminal plasma insulin-like growth factor-1 in male infertility. Clin Exp Reprod Med 43, 97–101 (2016)PubMedPubMedCentralCrossRef
17.
Z.R. Miao, T.K. Lin, T.A. Bongso, X. Zhou, P. Cohen et al. Effect of insulin-like growth factors (IGFs) and IGF-binding proteins on in vitro sperm motility. Clin Endocrinol (Oxf) 49, 235–239 (1998)CrossRef
18.
G. Naderi, H. Mohseni Rad, F. Tabassomi, A. Latif, Seminal insulin-like growth factor-I may be involved in the pathophysiology of infertility among patients with clinical varicocele. Hum Fertil (Camb) 18, 92–95 (2015)CrossRef
19.
K. Ramasharma, C.M. Cabrera, C.H. Li, Identification of insulin-like growth factor-II in human seminal and follicular fluids. Biochem Biophys Res Commun 140, 536–542 (1986)PubMedCrossRef
20.
R.G. Rosenfeld, H. Pham, Y. Oh, G. Lamson, L.C. Giudice, Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma. J Clin Endocrinol Metab 70, 551–553 (1990)PubMedCrossRef
21.
A.P. Chokkalingam, Y.T. Gao, J. Deng, F.Z. Stanczyk, I.A. Sesterhenn et al. Insulin-like growth factors and risk of benign prostatic hyperplasia. Prostate 52, 98–105 (2002)PubMedCrossRef
22.
A. Knuppel, G.K. Fensom, E.L. Watts, M.J. Gunter, N. Murphy et al. Circulating insulin-like growth factor-I concentrations and risk of 30 cancers: prospective analyses in UK Biobank. Cancer Res 80, 4014–4021 (2020)PubMedCrossRef
23.
E.L. Watts, G.K. Fensom, K. Smith Byrne, A. Perez-Cornago, N.E. Allen et al. Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank. Int J Cancer 148, 2274–2288 (2021)PubMedCrossRef
24.
J.M. Gomez, F.J. Maravall, N. Gomez, M.A. Navarro, R. Casamitjana et al. The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. Growth Horm IGF Res 14, 91–96 (2004)PubMedCrossRef
25.
J.K. Parsons, J. Bergstrom, J. Silberstein, E. Barrett-Connor, Prevalence and characteristics of lower urinary tract symptoms in men aged > or = 80 years. Urology 72, 318–321 (2008)PubMedCrossRef
26.
27.
K.O. Lee, Y. Oh, L.C. Giudice, P. Cohen, D.M. Peehl et al. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients. J Clin Endocrinol Metab 79, 1367–1372 (1994)PubMed
28.
T.G. Cooper, E. Noonan, S. von Eckardstein, J. Auger, H.W. Baker et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 16, 231–245 (2010)PubMedCrossRef
29.
World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 3rd edn Cambridge, 107 (1992)
30.
A. Bongso, A.K. Jarina, J. Ho, S.C. Ng, S.S. Ratnam, Comparative evaluation of three sperm-washing methods to improve sperm concentration and motility in frozen-thawed oligozoospermic and normozoospermic samples. Arch Androl 31, 223–230 (1993)PubMedCrossRef
31.
S. Sanchez-Luengo, P.J. Fernandez, A. Romeu, Insulin growth factors may be implicated in human sperm capacitation. Fertil Steril 83, 1064–1066 (2005)PubMedCrossRef
32.
A. Yilmaz, M.E. Davis, R.C. Simmen, Reproductive performance of bulls divergently selected on the basis of blood serum insulin-like growth factor I concentration. J Anim Sci 77, 835–839 (1999)PubMedCrossRef
33.
A. Hoeflich, H.D. Reichenbach, J. Schwartz, T. Grupp, M.M. Weber et al. Insulin-like growth factors and IGF-binding proteins in bovine seminal plasma. Domest Anim Endocrinol 17, 39–51 (1999)PubMedCrossRef
34.
S. Selvaraju, I.J. Reddy, S. Nandi, S.B. Rao, J.P. Ravindra, Influence of IGF-I on buffalo (Bubalus bubalis) spermatozoa motility, membrane integrity, lipid peroxidation and fructose uptake in vitro. Anim Reprod Sci 113, 60–70 (2009)PubMedCrossRef
35.
R.T. Padilha, D.M. Magalhaes-Padilha, M.M. Cavalcante, A.P. Almeida, K.T. Haag et al. Effect of insulin-like growth factor-I on some quality traits and fertility of cryopreserved ovine semen. Theriogenology 78, 907–913 (2012)PubMedCrossRef
36.
P. Kumar, Suman, S. Pawaria, J. Dalal, S. Bhardwaj et al. Serum and seminal plasma IGF-1 associations with semen variables and effect of IGF-1 supplementation on semen freezing capacity in buffalo bulls. Anim Reprod Sci 204, 101–110 (2019)PubMedCrossRef
37.
H. Rodriguez-Martinez, E. A. Martinez, J. J. Calvete, F. J. Pena Vega, J. Roca, Seminal plasma: relevant for fertility? Int J Mol Sci 22, 4368 (2021).PubMedPubMedCentralCrossRef
38.
P. Cohen, H.C. Graves, D.M. Peehl, M. Kamarei, L.C. Giudice et al. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 75, 1046–1053 (1992)PubMed
39.
P. Cohen, D.M. Peehl, H.C. Graves, R.G. Rosenfeld, Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease. J Endocrinol 142, 407–415 (1994)PubMedCrossRef
40.
P. Ovesen, A. Flyvbjerg, H. Orskov, Insulin-like growth factor I (IGF-I) and IGF binding proteins in seminal plasma before and after vasectomy in normal men. Fertil Steril 63, 913–918 (1995)PubMedCrossRef
41.
D.M. Henricks, A.J. Kouba, B.R. Lackey, W.R. Boone, S.L. Gray, Identification of insulin-like growth factor I in bovine seminal plasma and its receptor on spermatozoa: influence on sperm motility. Biol Reprod 59, 330–337 (1998)PubMedCrossRef
42.
43.
P. Cohen, D.M. Peehl, G. Lamson, R.G. Rosenfeld, Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. J Clin Endocrinol Metab 73, 401–407 (1991)PubMedCrossRef
44.
J. Janssen, A.J. Varewijck, M.P. Brugts, The insulin-like growth factor-I receptor stimulating activity (IRSA) in health and disease. Growth Horm IGF Res 48-49, 16–28 (2019)PubMedCrossRef
45.
J. Zhou, C. Bondy, Anatomy of the insulin-like growth factor system in the human testis. Fertil Steril 60, 897–904 (1993)PubMedCrossRef
46.
B.R. Lackey, W.R. Boone, S.L. Gray, D.M. Henricks, Computer-assisted sperm motion analysis of bovine sperm treated with insulin-like growth factor I and II: implications as motility regulators and chemokinetic factors. Arch Androl 41, 115–125 (1998)PubMedCrossRef
47.
D.F. Katz, E.Z. Drobnis, J.W. Overstreet, Factors regulating mammalian sperm migration through the female reproductive tract and oocyte vestments. Gamete Res 22, 443–469 (1989)PubMedCrossRef
48.
S.S. Suarez, X.B. Dai, R.P. DeMott, K. Redfern, M.A. Mirando, Movement characteristics of boar sperm obtained from the oviduct or hyperactivated in vitro. J Androl 13, 75–80 (1992)PubMed
49.
B. Carlsson, T. Hillensjo, A. Nilsson, J. Tornell, H. Billig, Expression of insulin-like growth factor-I (IGF-I) in the rat fallopian tube: possible autocrine and paracrine action of fallopian tube-derived IGF-I on the fallopian tube and on the preimplantation embryo. Endocrinology 133, 2031–2039 (1993)PubMedCrossRef
50.
M. Girbau, P.R. Gonzalez-Guerrero, L. Bassas, F. de Pablo, Insulin receptors and insulin-like growth factor I receptors in embryos from gastrula until organogenesis. Mol Cell Endocrinol 90, 69–75 (1992)PubMedCrossRef
51.
X. Zhang, G.M. Kidder, A.J. Watson, G.A. Schultz, D.T. Armstrong, Possible roles of insulin and insulin-like growth factors in rat preimplantation development: investigation of gene expression by reverse transcription-polymerase chain reaction. J Reprod Fertil 100, 375–380 (1994)PubMedCrossRef
52.
A. Bongso, S.C. Ng, C.Y. Fong, S. Ratnam, Improved fertilization rates of human oocytes in coculture. J In Vitro Fert Embryo Transf 8, 216–221 (1991)PubMedCrossRef
53.
T.A. Bongso, S.C. Ng, H. Mok, M.N. Lim, H.L. Teo et al. Effect of sperm motility on human in vitro fertilization. Arch Androl 22, 185–190 (1989)PubMedCrossRef
54.
Y. Al-Jebari, A. Elenkov, E. Wirestrand, I. Schutz, A. Giwercman et al. Risk of prostate cancer for men fathering through assisted reproduction: nationwide population based register study. Br Med J 366, l5214 (2019)CrossRef
55.
M.L. Eisenberg, S. Li, J.D. Brooks, M.R. Cullen, L.C. Baker, Increased risk of cancer in infertile men: analysis of U.S. claims data. J Urol 193, 1596–1601 (2015)PubMedCrossRef
56.
G. Dong, R. Rajah, T. Vu, A.R. Hoffman, R.G. Rosenfeld et al. Decreased expression of Wilms’ tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia. J Clin Endocrinol Metab 82, 2198–2203 (1997)PubMed
Metadaten
Titel
Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men
verfasst von
Li Fu
Kevin C. J. Yuen
Aye Nyein Tint
Andrew R. Hoffman
Ariff T. Bongso
Kok Onn Lee
Publikationsdatum
17.07.2021
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2021
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-021-02823-w

Weitere Artikel der Ausgabe 3/2021

Endocrine 3/2021 Zur Ausgabe

Research Letter

Pediatric multidisciplinary weight management—how can we improve further?

Original Article

Reduction of impulsivity in patients receiving deep transcranial magnetic stimulation treatment for obesity

Original Article

Distress, anxiety, depression and unmet needs in thyroid cancer survivors: a longitudinal study

Letter to the Editor

Letter to “Levothyroxine absorption test results in patients with TSH elevation resistant to treatment”

Original Article

Mild progressive osseous heteroplasia overlap syndrome with PTH and TSH resistance appearing during adolescence and not early childhood

Original Article

Identifying potential metabolic tissue biomarkers for papillary thyroid cancer in different iodine nutrient regions

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

06.05.2024 Kolonkarzinom Nachrichten

Menschen mit linksseitigem Kolonkarzinom leben im Mittel zweieinhalb Jahre länger als solche mit rechtsseitigem Tumor. Auch aktuell ist das Sterberisiko bei linksseitigen Tumoren US-Daten zufolge etwa um 11% geringer als bei rechtsseitigen.

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Wo hapert es noch bei der Umsetzung der POMGAT-Leitlinie?

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise