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Erschienen in: Archives of Osteoporosis 1/2022

01.12.2022 | Short Communication

Association of Helicobacter pylori infection with osteoporosis risk in a physical examination population

verfasst von: Ya-Fei Ye, Ya-Hong Chen, Dun Hong, Zhu Liduzi Jiesisibieke, Tao-Hsin Tung, Mei-Xian Zhang

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2022

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Abstract

Summary

The association between Helicobacter pylori (H. pylori) infection and osteoporosis risk remains equivocal. Our findings showed that H. pylori infection appears to have no effect on the risk of osteopenia and osteoporosis. Weight status may modify the association of H. pylori infection with low bone mass.

Purpose

To evaluate the association between baseline H. pylori infection and osteoporosis risk in the general population.

Methods

From January 1, 2019, to March 31, 2020, 1388 women and men aged over 50 years underwent a health examination. H. pylori infection was detected by the 13C urea breath test. Subjects were classified as having normal bone mineral density (BMD), osteopenia, and osteoporosis according to dual-energy X-ray absorptiometry. Chi-square tests and multinomial logistic regression models were performed to analyze the associations of H. pylori infection with osteopenia and osteoporosis.

Results

Of the 1388 participants, 545 (39.3%) were H. pylori-positive. The prevalence rates of osteoporosis and osteopenia were 10.2% and 32.3%, respectively. No differences were observed in the rates of osteoporosis and osteopenia between H. pylori-positive and H. pylori-negative groups (P > 0.05). The association for the trend between the H. pylori infection and osteoporosis was only seen in the nonoverweight subgroup (trend χ2 = 5.455, P = 0.02). The odds ratio (OR) between H. pylori infection and osteoporosis was 1.31 (95% CI, 0.86–2.02, P = 0.211) after adjusting for sex, age, and body weight status.

Conclusions

We demonstrate that H. pylori infection is not an independent risk factor for osteopenia and osteoporosis. This study did not support the association of H. pylori infection with osteoporosis.
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Metadaten
Titel
Association of Helicobacter pylori infection with osteoporosis risk in a physical examination population
verfasst von
Ya-Fei Ye
Ya-Hong Chen
Dun Hong
Zhu Liduzi Jiesisibieke
Tao-Hsin Tung
Mei-Xian Zhang
Publikationsdatum
01.12.2022
Verlag
Springer London
Erschienen in
Archives of Osteoporosis / Ausgabe 1/2022
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-022-01074-0

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