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Archives of Gynecology and Obstetrics

Erschienen in:

01.05.2014 | General Gynecology

Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women: a meta-analysis

verfasst von: Hongxiu Zhang, Xincheng Tao, Jie Wu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2014

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Abstract

Background

The relationship of homocysteine (Hcy), folate, and vitamin B12 with bone mineral density (BMD) has been investigated in postmenopausal women. However, the relationship is still controversial.

Purpose

To evaluate the association of Hcy, folate, vitamin B12 and BMD in postmenopausal women with a meta-analysis.

Methods

We searched for all published articles indexed in Medline (1950–2012), Embase (1974–2012), and China National Knowledge Infrastructure (1994–2012). Any case–control or cohort study relating to Hcy, vitamin B12, folate, and BMD was included, and the data were extracted independently by two reviewers. Criteria for inclusion were the assessment of Hcy, vitamin B12, folate, and BMD in postmenopausal women as outcomes. We performed this meta-analysis with Review Manager 5.1 software. Odds ratios and 95 % confidence intervals (CI) were used to evaluate the results.

Results

Six eligible studies were selected for meta-analysis. Our analysis suggested that vitamin B12 and Hcy levels were significantly higher in postmenopausal osteoporosis (PMOP) group than that in controls (P = 0.007, <0.05; 95 % CI 3.06–19.38 and P = 0.0003, <0.05; 95 % CI 0.75–2.52, respectively). Folate level was lower in PMOP group than that in controls, but this difference was not statistically significant (P = 0.09, 95 % CI −3.33 to 0.25).

Conclusions

Hcy and vitamin B12, but not folate, were related to BMD in PMOP. Extra vitamin B12 may not play a protective role for osteoporosis in postmenopausal women. Future studies are needed to confirm them, especially the relationship between increased vitamin B12 and BMD.

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Titel: Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women: a meta-analysis
verfasst von: Hongxiu Zhang
Xincheng Tao
Jie Wu
Publikationsdatum: 01.05.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 5/2014
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3075-6

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