Erschienen in:
09.02.2016 | Research Letter
Association of primary aldosteronism with chronic thyroiditis
verfasst von:
Chiara Sabbadin, Caterina Mian, Davide Nacamulli, Gabriella Donà, Fabio Presotto, Corrado Betterle, Marco Boscaro, Luciana Bordin, Decio Armanini
Erschienen in:
Endocrine
|
Ausgabe 1/2017
Einloggen, um Zugang zu erhalten
Excerpt
Primary aldosteronism (PA) is associated with an increased risk of cardio- and cerebro-vascular events, mediated not only by its hypertensive effect but also by its proinflammatory action [
1]. Recent studies suggest a role of aldosterone in the development and/or progression of autoimmune disorders: aldosteronism is associated with an activation of circulating immune cells, which is attenuated by mineralocorticoid receptor (MR)-antagonists [
2]. We previously characterized MR in circulating mononuclear leukocytes (MNL) and found an increased protein expression of PAI-1 and p22(phox) after incubation of MNL with aldosterone, this effect being reversed by coincubation with canrenone [
3,
4]. Aldosterone can directly increase the capacity of dendritic cells to activate CD8
+T cells and induce Th17 polarization of CD4
+T cells, which have been associated with many autoimmune diseases, and a recent study has found an increased expression of Th17-related factors in autoimmune thyroiditis (AIT) [
5,
6]. …
