Background
Methods
Identification of eligible studies
Inclusion and exclusion criteria
Quality score assessment
Data extraction
Statistical analysis
Results
Characteristics of eligible studies
Author | Year | Country | Ethnicity | NOS scores | Sample size | Genotype in cases | Genotype in controls | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PCOS | Control | CC | AC | AA | CC | AC | AA | |||||
Dasgupta [14] | 2015 | India | Asian | 7 | 250 | 250 | 13 | 120 | 117 | 13 | 117 | 120 |
Jedrzejuk [15] | 2015 | Poland | Caucasian | 7 | 90 | 98 | 19 | 52 | 19 | 17 | 49 | 32 |
Mahmoudi [16] | 2015 | Iran | Asian | 8 | 35 | 35 | 9 | 11 | 15 | 6 | 21 | 8 |
Mahmoudi [17] | 2009 | Iran | Asian | 8 | 162 | 162 | 36 | 68 | 58 | 23 | 90 | 49 |
El-Shal [18] | 2013 | Egypt | Caucasian | 8 | 150 | 150 | 22 | 65 | 63 | 18 | 64 | 68 |
Siddamalla [19] | 2017 | India | Asian | 7 | 95 | 130 | 32 | 21 | 42 | 25 | 35 | 70 |
Wehr [20] | 2011 | Australia | Caucasian | 7 | 543 | 145 | 127 | 274 | 142 | 37 | 60 | 48 |
Cao [21] | 2016 | China | Asian | 7 | 120 | 120 | 40 | 58 | 22 | 26 | 55 | 39 |
Santos [22] | 2018 | Brazil | Caucasian | 7 | 190 | 100 | 41 | 88 | 61 | 16 | 48 | 36 |
Author | Year | Country | Ethnicity | NOS scores | Sample size | Genotype in cases | Genotype in controls | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PCOS | Control | GG | AG | AA | GG | AG | AA | |||||
Jedrzejuk [15] | 2015 | Poland | Caucasian | 7 | 90 | 98 | 31 | 45 | 14 | 43 | 42 | 13 |
Mahmoudi [16] | 2015 | Iran | Asian | 8 | 35 | 35 | 13 | 12 | 10 | 7 | 23 | 5 |
Mahmoudi [17] | 2009 | Iran | Asian | 8 | 162 | 162 | 53 | 85 | 24 | 53 | 91 | 18 |
Bagheri [23] | 2012 | Iran | Asian | 7 | 46 | 46 | 4 | 27 | 15 | 2 | 24 | 20 |
Siddamalla [19] | 2017 | India | Asian | 7 | 94 | 130 | 34 | 45 | 15 | 17 | 41 | 72 |
Wehr [20] | 2011 | Australia | Caucasian | 7 | 537 | 137 | 77 | 244 | 216 | 49 | 66 | 22 |
Cao [21] | 2016 | China | Asian | 7 | 120 | 120 | 37 | 60 | 23 | 25 | 55 | 40 |
Santos [22] | 2018 | Brazil | Caucasian | 7 | 187 | 100 | 74 | 76 | 37 | 41 | 48 | 11 |
Author | Year | Country | Ethnicity | NOS scores | Sample size | Genotype in cases | Genotype in controls | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PCOS | Control | CC | CT | TT | CC | CT | TT | |||||
Dasgupta [14] | 2015 | India | Asian | 7 | 252 | 401 | 47 | 92 | 113 | 105 | 110 | 186 |
Jedrzejuk [15] | 2015 | Poland | Caucasian | 7 | 90 | 98 | 8 | 45 | 37 | 12 | 37 | 49 |
Mahmoudi [16] | 2015 | Iran | Asian | 8 | 35 | 35 | 6 | 14 | 15 | 4 | 16 | 15 |
Mahmoudi [17] | 2009 | Iran | Asian | 8 | 162 | 162 | 20 | 71 | 71 | 14 | 76 | 72 |
El-Shal [18] | 2013 | Egypt | Caucasian | 8 | 150 | 150 | 36 | 74 | 40 | 20 | 61 | 69 |
Siddamalla [19] | 2017 | India | Asian | 7 | 95 | 130 | 24 | 31 | 40 | 17 | 42 | 71 |
Bagheri [24] | 2013 | Iran | Asian | 7 | 38 | 38 | 8 | 14 | 16 | 2 | 19 | 17 |
Wehr [20] | 2011 | Australia | Caucasian | 7 | 536 | 137 | 72 | 238 | 226 | 23 | 65 | 49 |
Cao [21] | 2016 | China | Asian | 7 | 120 | 120 | 11 | 52 | 57 | 8 | 72 | 40 |
Santos [22] | 2018 | Brazil | Caucasian | 7 | 188 | 99 | 70 | 87 | 31 | 40 | 48 | 11 |
Author | Year | Country | Ethnicity | NOS scores | Sample size | Genotype in cases | Genotype in controls | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PCOS | Control | TT | TC | CC | TT | TC | CC | |||||
Dasgupta [14] | 2015 | India | Asian | 7 | 250 | 249 | 8 | 87 | 155 | 9 | 88 | 152 |
Jedrzejuk [15] | 2015 | Poland | Caucasian | 7 | 90 | 98 | 11 | 51 | 28 | 25 | 50 | 23 |
Mahmoudi [16] | 2015 | Iran | Asian | 8 | 35 | 35 | 2 | 17 | 16 | 1 | 10 | 24 |
Mahmoudi [17] | 2009 | Iran | Asian | 8 | 162 | 162 | 12 | 67 | 83 | 7 | 59 | 96 |
Bagheri [23] | 2012 | Iran | Asian | 7 | 46 | 46 | 22 | 20 | 4 | 29 | 15 | 2 |
Wehr [20] | 2011 | Australia | Caucasian | 7 | 538 | 135 | 82 | 241 | 215 | 22 | 60 | 53 |
Cao [21] | 2016 | China | Asian | 7 | 120 | 120 | 10 | 40 | 70 | 10 | 45 | 65 |
Author | Year | Country | Ethnicity | NOS scores | Sample size | Genotype in cases | Genotype in controls | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PCOS | Control | AA | AG | GG | AA | AG | GG | |||||
Bagheri [23] | 2012 | Iran | Asian | 7 | 181 | 181 | 7 | 51 | 123 | 6 | 48 | 127 |
Ranjzad [25] | 2012 | Iran | Asian | 8 | 35 | 35 | 1 | 6 | 28 | 0 | 8 | 27 |
Zadeh-Vakili [26] | 2013 | Iran | Asian | 8 | 221 | 260 | 6 | 58 | 157 | 8 | 66 | 186 |
Meta-analysis results of VDR ApaI rs7975232 (A > C) variant and PCOS susceptibility
Polymoyphisms | Population | Genetic model | Genetic model | No. of studies | Test of association | Model | Test of heterogeneity | Egger’s test(P) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P-value | P-value | I2 (%) | |||||||
rs7975232 | All | C vs. A | Allelic | 9 | 1.19 | 1.06~1.34 | 0.004 | F | 0.170 | 32.5 | 0.676 |
VDR ApaI | CC vs. CA + AA | Dominant | 9 | 1.35 | 1.09~1.69 | 0.008 | F | 0.310 | 16.0 | 0.145 | |
CC + CA vs. AA | Recessive | 9 | 1.20 | 1.01~1.42 | 0.042 | F | 0.050 | 50.0 | 0.132 | ||
Asian | C vs. A | Allelic | 5 | 1.21 | 1.04~1.42 | 0.016 | F | 0.060 | 57.9 | 0.963 | |
CC vs. CA + AA | Dominant | 5 | 1.70 | 1.26~2.29 | 0.001 | F | 0.700 | 0.0 | 0.265 | ||
CC + CA vs. AA | Recessive | 5 | 1.10 | 0.88~1.37 | 0.411 | R | 0.018 | 66.4 | 0.234 | ||
Caucasian | C vs. A | Allelic | 4 | 1.17 | 0.98~1.38 | 0.053 | F | 0.849 | 0.0 | 0.452 | |
CC vs. CA + AA | Dominant | 4 | 1.11 | 0.83~1.48 | 0.470 | F | 0.578 | 0.0 | 0.145 | ||
CC + CA vs. AA | Recessive | 4 | 1.32 | 0.89~1.46 | 0.084 | F | 0.683 | 0.0 | 0.247 | ||
rs1544410 | All | G vs. A | Allelic | 8 | 1.11 | 0.91~1.37 | 0.307 | R | 0.030 | 54.8 | 0.462 |
VDR BsmI | GG vs. GA + AA | Dominant | 8 | 0.94 | 0.75~1.17 | 0.556 | F | 0.280 | 20 | 0.563 | |
GG + GA vs. AA | Recessive | 8 | 1.08 | 0.45~2.62 | 0.860 | R | 0.030 | 57 | 0.245 | ||
Asian | G vs. A | Allelic | 5 | 1.27 | 1.06~1.53 | 0.011 | F | 0.114 | 46.3 | 0.256 | |
GG vs. CA + AA | Dominant | 5 | 1.89 | 1.08~3.30 | 0.026 | R | 0.027 | 63.5 | 0.356 | ||
GG + GA vs. AA | Recessive | 5 | 1.54 | 0.63~3.76 | 0.342 | R | 0.001 | 86.1 | 0.235 | ||
Caucasian | G vs. A | Allelic | 3 | 0.95 | 0.78~1.15 | 0.597 | F | 0.180 | 41.7 | 0.751 | |
GG vs. CA + AA | Dominant | 3 | 0.57 | 0.27~1.18 | 0.128 | R | 0.002 | 84.3 | 0.156 | ||
GG + GA vs. AA | Recessive | 3 | 0.46 | 0.35~1.28 | 0.136 | R | 0.069 | 62.7 | 0.237 | ||
rs731236 | All | C vs. T | Allelic | 10 | 1.14 | 0.93~1.40 | 0.218 | R | 0.001 | 67.5 | 0.452 |
VDR TaqI | CC vs. TC + TT | Dominant | 10 | 1.20 | 0.84~1.71 | 0.322 | R | 0.006 | 61.1 | 0.564 | |
CC + TC vs. TT | Recessive | 10 | 1.07 | 0.81~1.41 | 0.628 | R | 0.003 | 63.5 | 0.521 | ||
Asian | C vs. T | Allelic | 6 | 1.09 | 0.85~1.41 | 0.493 | R | 0.034 | 58.6 | 0.426 | |
CC vs. CT + TT | Dominant | 6 | 1.46 | 0.81~2.64 | 0.207 | R | 0.008 | 68.2 | 0.359 | ||
CC + CT vs. TT | Recessive | 6 | 1.02 | 0.83~1.24 | 0.858 | F | 0.128 | 41.6 | 0.215 | ||
Caucasian | C vs. A | Allelic | 4 | 1.19 | 0.82~1.74 | 0.359 | R | 0.002 | 79.5 | 0.568 | |
CC vs. CA + AA | Dominant | 4 | 1.01 | 0.63~1.63 | 0.961 | R | 0.062 | 59.1 | 0.356 | ||
CC + CA vs. AA | Recessive | 4 | 1.15 | 0.63~2.10 | 0.654 | R | 0.001 | 80.8 | 0.628 | ||
rs2228570 | All | T vs. C | Allelic | 7 | 1.04 | 0.83~1.30 | 0.715 | R | 0.050 | 52.3 | 0.539 |
VDR FokI | TT vs. CT + CC | Dominant | 7 | 0.90 | 0.65~1.24 | 0.521 | F | 0.291 | 18.1 | 0.759 | |
TT + CT vs. CC | Recessive | 7 | 1.06 | 0.88~1.27 | 0.569 | F | 0.149 | 36.6 | 0.349 | ||
Asian | T vs. C | Allelic | 5 | 1.13 | 0.94~1.37 | 0.190 | F | 0.150 | 40.8 | 0.564 | |
TT vs. CT + CC | Dominant | 5 | 1.26 | 0.76~2.08 | 0.374 | F | 0.785 | 0.0 | 0.486 | ||
TT + CT vs. CC | Recessive | 5 | 1.15 | 0.92~1.44 | 0.233 | F | 0.136 | 42.8 | 0.843 | ||
Caucasian | C vs. A | Allelic | 2 | 0.85 | 0.68~1.07 | 0.173 | F | 0.124 | 57.7 | – | |
CC vs. CA + AA | Dominant | 2 | 0.65 | 0.29~1.44 | 0.284 | R | 0.084 | 66.5 | – | ||
CC + CA vs. AA | Recessive | 2 | 0.88 | 0.63~1.23 | 0.465 | F | 0.352 | 0.0 | – | ||
rs757343 | All (Asian) | A vs. G | Allelic | 3 | 1.04 | 0.81~1.34 | 0.734 | F | 0.939 | 0.0 | 0.428 |
VDR Tru9I | AA vs. AG + GG | Dominant | 3 | 1.09 | 0.52~2.28 | 0.830 | F | 0.753 | 0.0 | 0.740 | |
AA+AG vs. GG | Recessive | 3 | 1.05 | 0.79~1.39 | 0.759 | F | 0.899 | 0.0 | 0.445 |