Background
Results
Search results
Characteristics of trials included in this meta-analysis
Study | NCA | NCO | Mutation site | Detection method | Matching factors | |||
---|---|---|---|---|---|---|---|---|
Age | Sex | Genotype | HBV DNA | |||||
Aiming Zhang, 2013 | 29 | 52 | T1753V, A1762T, G1764A, A1762T/G1764A, A1846T, G1896A, G1899A | NP, AS | + | + | + | + |
Aiming Zhang2, 2013 | 58 | 51 | T1753V, A1762T, G1764A, A1762T/G1764A, A1846T, G1896A, G1899A | NP, AS | + | + | + | + |
Lei Xiao, 2013 | 77 | 136 | T1753V, A1762T/G1764A, C1766T, T1768A, A1846T, G1862T, G1896A, G1899A | NP, AS | + | + | - | - |
Xiaodong Li, 2013 | 146 | 239 | T1753V, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A | NP, AS | + | + | - | - |
X Ren, 2010 (40) | 75 | 328 | T1753V, A1762T, G1764A, C1766T, T1768A, G1896A, G1899A | NP, AS | + | + | + | + |
Zhihui Xu, 2010 | 298 | 495 | T1753V, A1762T, G1764A, C1766T, T1768A, G1862T, G1896A, G1899A | NP, AS | + | + | + | - |
Ling Yang, 2010 | 39 | 44 | A1762T/G1764A, G1862T, G1896A, G1899A | SNP, AS | - | + | + | - |
Zhengang Zhao, 2010 | 20 | 19 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A | NP, DS | - | + | + | - |
Xiaoyan Ma, 2012 | 44 | 28 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A, A1762T/G1764A/G1896A | NP, S | - | + | + | - |
Zhiwei Li, 2002 | 13 | 10 | A1846T, G1862T, G1896A | RP, SA | ND | ND | ND | - |
Shoubing Tang, 2005 | 30 | 30 | A1762T/G1764A, G1896A | RP, CS | + | + | ND | - |
Yintang Jia, 2009 | 8 | 78 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A | NP, DS | ND | ND | ND | - |
Ling Jiang, 2013 | 146 | 239 | A1762T/G1764A, G1896A | QPMK, DS | + | + | ND | - |
Wenjun Du, 2005 | 9 | 75 | A1762T, G1764A, G1896A | RP, GC, S | ND | ND | ND | - |
Xiumei Zhou, 2009 | 80 | 80 | A1762T/G1764A, G1896A, G1899A | RP, GC | + | + | ND | - |
Mingxian Zhou, 2004 | 22 | 56 | A1762T, G1896A | UK | ND | ND | + | - |
Xiaoqiang Ren, 2009 | 348 | 610 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A | NP, AS | + | + | + | - |
Lei Jiang, 2010 | 26 | 78 | G1896A | NP, RFLP | ND | ND | ND | - |
Jinqiang Li, 2006 | 30 | 20 | A1762T/G1764A, G1896A | RP, MS | + | + | ND | - |
Chengyong Liu, 2007 | 34 | 186 | A1762T/G1764A, G1896A, A1762T/G1764A/G1896A | RP, MGS | ND | ND | ND | - |
Xinyu Liu, 2005 | 14 | 75 | A1762T, G1764A, A1762T/G1764A, G1896A, A1762T/G1764A/G1896A | LAS | ND | ND | ND | - |
Shuren Liang, 2003 | 23 | 68 | G1896A | RP, OAS | ND | + | ND | - |
Zhidong Zang, 2007 | 17 | 81 | A1762T/G1764A | RP, LAS | ND | ND | ND | - |
Tao Yan, 2010 | 49 | 45 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A, A1762T/G1764A/G1896A | NP, AS | - | + | + | - |
Wei Guo, 2006 | 38 | 40 | T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A | RP, CS | + | + | ND | - |
Yanhong Yu, 2008 | 25 | 98 | A1762T/G1764A | RP, GC | ND | ND | ND | - |
Guanghui Wu, 2008 | 30 | 30 | A1762T/G1764A, G1896A | RP, RFLP | ND | + | + | - |
Hangdi Xu, 2013 | 12 | 12 | A1762T, G1764A, A1846T, G1896A | RP, IS | + | + | + | + |
Fan Li, 2008 (31) | 87 | 196 | T1753V, A1762T, G1764A, G1862T, G1896A, G1899A | NP, AS | ND | + | ND | - |
Lu Xu, 2012 | 64 | 69 | T1753V, A1762T, G1764A, A1762T/G1764A, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A | RP, AS | + | - | ND | - |
Hangdi Xu2, 2013 | 104 | 254 | A1846T, G1896A | SNP, AS | ND | - | - | - |
Patient characteristics
Trials | Group | N | Age, y | Gender (m/f) | Genotype (B/O) | HBeAg (P/N) | TB (μmol/L) | HBV DNA (log10IU/ml) |
---|---|---|---|---|---|---|---|---|
Aiming Zhang | A | 29 | 43.4 | 27/2 | 7/22 | 11/18 | 330.2 | 3.86 |
C | 52 | 42.3 | 42/10 | 16/36 | 32/20 | NG | 4.63 | |
Aiming Zhang2 | A | 58 | 47.4 | 48/10 | 12/46 | 26/32 | 338.4 | 4.02 |
C | 51 | 46.2 | 39/12 | 8/43 | 19/32 | NG | 4.69 | |
Lei Xiao | A | 77 | 38.2 | 70/7 | 71/6 | 22/55 | 427.5 | NG |
C | 136 | 36.9 | 113/23 | 82/54 | 79/57 | 37.62 | NG | |
Xiaodong Li | A | 146 | 47.4 | 119/27 | 30/116 | 45/101 | 313.4 | 5 |
C | 239 | 46.2 | 207/32 | 52/187 | 140/99 | 74.4 | 5.8 | |
X Ren | A | 75 | 39 | 67/8 | 23/52 | 29/46 | 451 | 5.3 |
C | 328 | 38 | 281/47 | 54/274 | 194/134 | 12.8 | 5.2 | |
Zhihui Xu | A | 298 | 45.9 | 255/43 | 63/235 | 99/199 | 418.5 | 5.48 |
C-M/S | 495 | 38.3/39.1 | 427/68 | 82/413 | 261/234 | 16.4/164.2 | 5.26/5.99 | |
Ling Yang | A | 39 | 36 | 36/3 | 24/10 | 11/28 | 353 | 5.75 |
C | 44 | 26 | 36/8 | 22/22 | 36/8 | NG | 9.16 | |
Zhengang Zhao | A | 20 | 49.7 | 14/6 | 0/16 | 8/12 | 287.37 | 5.82 |
C | 19 | 40.37 | 14/5 | 2/15 | 14/5 | 19.75 | 7.67 | |
Xiaoyan Ma | A | 44 | 51.6 | 31/13 | 0/44 | NG | NG | NG |
C | 28 | 38.7 | 20/8 | 2/26 | NG | NG | NG | |
Zhiwei Li | A | 13 | 21 to 58 | 17/6 | NG | NG | NG | NG |
C | 10 | NG | NG | NG | NG | |||
Shoubing Tang | A | 30 | 21 | 25/5 | NG | 13/17 | NG | 1.47 |
C | 30 | 20 | 24/6 | NG | 16/14 | NG | 3.29 | |
Yintang Jia | A | 8 | NG | NG | NG | NG | NG | NG |
C | 78 | NG | NG | NG | NG | NG | NG | |
Ling Jiang | A | 146 | 46 | 119/27 | NG | 49/97 | 313.4 | 5 |
C-M/S | 239 | 41/38 | 206/33 | NG | 146/93 | 42.38/106.54 | 6.27/5.39 | |
Wenjun Du | A | 9 | NG | NG | NG | NG | NG | NG |
C | 75 | NG | NG | NG | NG | NG | NG | |
Xiumei Zhou | A | 80 | 48.6 | 108/72 | NG | NG | NG | NG |
C | 80 | NG | NG | NG | NG | |||
Mingxian Zhou | A | 22 | NG | NG | 3/19 | NG | NG | 4.31 |
C | 56 | NG | NG | 9/47 | NG | NG | 4.72 | |
Xiaoqiang Ren | A | 348 | 46 | 292/56 | 53/200 | 132/216 | 255.9 | 4.55 |
C-M/S | 610 | 38/35 | 518/92 | 95/476 | 386/224 | 12.4/55.4 | 4.43/5.21 | |
Lei Jiang | A | 26 | NG | NG | NG | NG | NG | NG |
C | 78 | NG | NG | NG | NG | NG | NG | |
Jinqiang Li | A | 30 | 48.1 | 24/6 | NG | NG | NG | NG |
C | 20 | 43.9 | 15/5 | NG | NG | NG | NG | |
Chengyong Liu | A | 34 | NG | NG | NG | NG | NG | NG |
C | 186 | NG | NG | NG | NG | NG | NG | |
Xinyu Liu | A | 14 | NG | NG | NG | NG | NG | NG |
C | 75 | NG | NG | NG | NG | NG | NG | |
Shuren Liang | A | 23 | 39.71 | 18/5 | NG | NG | NG | NG |
C-M0/M1/S | 68 | 35/36.1/35.5 | 55/13 | NG | NG | NG | NG | |
Zhidong Zang | A | 17 | NG | 10/7 | NG | NG | 342.3 | 2.25 |
C | 81 | NG | 64/17 | NG | NG | 51.9 | 1.83 | |
Tao Yan | A | 49 | 45.8 | 42/7 | 9/40 | 23/26 | 312.2 | 4.88 |
C | 45 | 33.9 | 36/9 | 12/33 | 36/9 | 16.5 | 6.91 | |
Wei Guo | A | 38 | 32.6 | 34/4 | NG | 21/17 | NG | 5.09 |
C | 40 | 30.2 | 33/7 | NG | 26/14 | NG | 5.48 | |
Yanhong Yu | A | 25 | NG | NG | NG | NG | NG | NG |
C | 98 | NG | NG | NG | NG | NG | NG | |
Guanghui Wu | A | 30 | 40 | 25/5 | 6/24 | NG | NG | NG |
C | 30 | 29 | 20/10 | 4/26 | NG | NG | NG | |
Hangdi Xu | A | 12 | 35 | 11/1 | 10/2 | 4/8 | 324.9 | 6.71 |
C | 12 | 35.7 | 10/2 | 8/4 | 10/2 | 15.6 | 6.74 | |
Fan Li | A | 87 | 45.4 | 69/18 | NG | 27/60 | 331 | 4.42 |
C | 196 | 38.8 | 170/26 | NG | 130/66 | 23.8 | 5.42 | |
Lu Xu | A | 64 | 35.1 | 57/7 | NG | 31/33 | 372.2 | 3.89 |
C | 69 | 29.5 | 48/21 | NG | 53/16 | 46.5 | 5.49 | |
Hangdi Xu2 | A | 104 | 40.9 | 91/13 | 68/36 | 51/53 | 317.5 | 6.09 |
C-M/S | 254 | 37.6/40.7 | 186/68 | 51/203 | 185/69 | 14.9/98.3 | 6.14/5.77 |
Data synthesis
Overall risk estimates
Subgroup analysis
Mutation site | Matching factor | OR | _LCI | _UCI |
P
|
---|---|---|---|---|---|
T1753V | unmatched | 1.919 | 1.414 | 2.606 | 0.000 |
age and sex matched | 1.481 | 0.982 | 2.234 | 0.061 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND | |
A1762T | unmatched | 2.685 | 2.264 | 3.185 | 0.000 |
age and sex matched | 2.307 | 1.555 | 3.422 | 0.000 | |
age, sex, genotype and HBV DNA matched | 1.326 | 0.585 | 3.007 | 0.499 | |
G1764A | unmatched | 2.901 | 2.041 | 4.122 | 0.000 |
age and sex matched | 2.023 | 1.013 | 4.041 | 0.046 | |
age, sex, genotype and HBV DNA matched | 1.310 | 0.555 | 3.094 | 0.538 | |
A1762T/G1764A | unmatched | 2.376 | 1.548 | 3.648 | 0.000 |
age and sex matched | 2.602 | 1.270 | 5.333 | 0.009 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND | |
G1896A | unmatched | 2.181 | 1.800 | 2.642 | 0.000 |
age and sex matched | 2.014 | 1.505 | 2.695 | 0.000 | |
age, sex, genotype and HBV DNA matched | 1.479 | 1.017 | 2.152 | 0.041 | |
G1899A | unmatched | 3.525 | 2.882 | 4.312 | 0.000 |
age and sex matched | 3.171 | 2.464 | 4.081 | 0.000 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND | |
C1766T | unmatched | 1.849 | 1.403 | 2.437 | 0.000 |
age and sex matched | 1.719 | 1.226 | 2.411 | 0.002 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND | |
T1768A | unmatched | 2.199 | 1.563 | 3.094 | 0.000 |
age and sex matched | 2.203 | 1.425 | 3.405 | 0.000 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND | |
A1846T | unmatched | 3.163 | 2.157 | 4.639 | 0.000 |
age and sex matched | 2.854 | 2.127 | 3.831 | 0.000 | |
age, sex, genotype and HBV DNA matched | ND | ND | ND | ND |
Prediction of ACLF by HBV mutation
Mutation site | Mutation status | No. of ACLF patients | No. of patients without ACLF | Sensitivity % (95 % CI) | Specificity, % (95 % CI) | PPV | NPV |
---|---|---|---|---|---|---|---|
T1753V | pos | 392 | 397 | 29.3 (26.9 to 31.9) | 83.3 (81.8 to 84.8) | 49.7 (46.1 to 53.2) | 67.8 (66.0 to 69.5) |
neg | 945 | 1986 | |||||
A1762T | pos | 872 | 1207 | 74.5 (71.9 to 76.9) | 45.8 (43.7 to 47.9) | 41.9 (39.8 to 44.1) | 77.3 (75.0 to 80.0) |
neg | 299 | 1019 | |||||
G1764A | pos | 921 | 228 | 43.0 (40.9 to 45.1) | 80.6 (78.3 to 82.9) | 80.1 (77.7 to 82.4) | 43.7 (41.6 to 45.9) |
neg | 1221 | 949 | |||||
A1762T/G1764A | pos | 678 | 825 | 51.6 (48.9 to 54.4) | 63.1 (61.1 to 65.1) | 45.1 (42.6 to 47.7) | 69.0 (66.9 to 71.0) |
neg | 635 | 1412 | |||||
C1766T | pos | 113 | 118 | 10.3 (8.6 to 12.2) | 94.1 (93.0 to 95.1) | 48.9 (42.3 to 55.6) | 65.8 (64.0 to 67.5) |
neg | 986 | 1897 | |||||
T1768A | pos | 80 | 64 | 6.9 (5.5 to 8.5) | 96.9 (96.1 to 97.6) | 55.6 (47.1 to 63.8) | 65.1 (63.4 to 66.8) |
neg | 1083 | 2020 | |||||
A1846T | pos | 304 | 251 | 54.7 (50.4 to 58.9) | 72.8 (69.8 to 75.6) | 54.8 (50.5 to 59.0) | 72.7 (69.7 to 75.5) |
neg | 252 | 670 | |||||
G1896A | pos | 1025 | 1254 | 52.6 (50.4 to 54.8) | 65.6 (64.0 to 67.1) | 45.0 (42.9 to 47.0) | 72.1 (70.5 to 73.6) |
neg | 924 | 2386 | |||||
G1899A | pos | 323 | 182 | 22.2 (20.1 to 24.4) | 92.7 (91.7 to 93.7) | 64.0 (59.6 to 68.2) | 67.2 (65.6 to 68.8) |
neg | 1133 | 2325 | |||||
G1896A/A1762T/G1764A | pos | 107 | 135 | 17.6 (14.7 to 20.9) | 87.4 (85.2 to 89.3) | 44.2 (37.9 to 50.7) | 65.1 (62.6 to 67.6) |
neg | 500 | 934 |
HBV genotype and HBeAg status
Assessment of within-group heterogeneity, publication bias and sensitivity analysis
Mutation site |
P value for heterogeneity |
P value for Egger’s test | Sensitivity analysis |
---|---|---|---|
T1753V | 0.006 | 0.923 | - |
A1762T | 0.164 | 0.181 | - |
G1764A | 0.004 | 0.100 | - |
A1762T/G1764A | 0.000 | 0.455 | - |
C1766T | 0.852 | 0.300 | - |
T1768A | 0.681 | 0.291 | - |
A1846T | 0.037 | 0.856 | - |
G1862T | 0.001 | 0.125 | + |
G1896A | 0.002 | 0.520 | - |
G1899A | 0.307 | 0.591 | - |
G1896A/A1762T/G1764A | 0.073 | 0.045 | - |