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Inflammation

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01.10.2010

Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

verfasst von: Alicja Kasperska-Zajac

Erschienen in: Inflammation | Ausgabe 5/2010

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Abstract

Dehydroepiandrosterone (DHEA) is considered as an important immunomodulating and anti-inflammatory hormone. Despite the continuing interest in DHEA replacement therapy, our knowledge of its effects upon asthma is very limited. DHEA is able to reverse cytokine imbalances associated with asthma, may prevent and attenuate allergic inflammation in airways, and does not possess the undesirable side effects of glucocorticoids; therefore, it may be potentially applied in the treatment of asthma. The steroid-sparing effect observed with DHEA clinically could appear especially favorable in asthmatic patients receiving oral treatment and those inhaling high doses of glucocorticoids. In addition, DHEA and its analogs might prove useful in reversing relative glucocorticoids insensitivity in patients with corticosteroid-resistant asthma. In this review we have focused specifically on DHEA’s role in asthma.

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Titel: Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses
verfasst von: Alicja Kasperska-Zajac
Publikationsdatum: 01.10.2010
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 5/2010
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-010-9188-1

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