Erschienen in:
01.09.2012 | Letter to the Editor
Ataxia and HIV: Clinicopathologic Correlations in a Case of HIV-Associated Cerebellar Leukoencephalopathy
verfasst von:
Christos Ganos, Christian Bernreuther, Jakob Matschke, Christian Gerloff, Alexander Münchau, Frank Leypoldt
Erschienen in:
The Cerebellum
|
Ausgabe 3/2012
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Excerpt
The widespread application of highly active anti-retroviral treatment (HAART) has had a very positive impact on the clinical course of human immunodeficiency virus (HIV) infection. However, neurological complications in long-term survivors still pose a considerable and possibly growing problem [
1]. Currently, neurocognitive impairment and polyneuropathy are common chronic neurological sequelae of HIV infection. In contrast, the occurrence of ataxia in HIV-infected individuals is unusual and should prompt further diagnostic work-up. In the pre-HAART era, the most common symptomatic causes of ataxia were opportunistic infections, progressive multifocal leucoencephalopathy (PML), lymphomas or strokes caused by varicella zoster virus vasculitis. Furthermore, ataxia was observed in the context of HIV dementia complex [
2,
3]. In the post-HAART era, this spectrum has changed considerably. …