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BioDrugs

01.10.2016 | Adis Drug Evaluation

BAY 81-8973 (Octocog Alfa; Kovaltry®): A Review in Haemophilia A

Erschienen in: BioDrugs | Ausgabe 5/2016

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Abstract

BAY 81-8973 (octocog alfa; Kovaltry®) is an unmodified, full-length, recombinant factor VIII (FVIII) concentrate with the same amino acid sequence as Kogenate® FS, but produced with innovative manufacturing technologies. This narrative review discusses the clinical efficacy and tolerability of BAY 81-8973 in haemophilia A, as well as summarizing its pharmacological properties. Results of the LEOPOLD I, LEOPOLD II and LEOPOLD Kids trials demonstrated that routine prophylaxis with intravenous BAY 81-8973 was associated with a low annualized bleeding rate (ABR) in previously treated adult and paediatric patients with severe haemophilia A. In terms of the ABR, BAY 81-8973 prophylaxis was more effective than on-demand treatment. Intravenous BAY 81-8973 was generally well tolerated, with no inhibitor development reported in previously treated patients in the completed LEOPOLD trial programme. In conclusion, BAY 81-8973 is a useful option for prophylaxis and treatment in adult and paediatric patients with haemophilia A.
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Metadaten
Titel
BAY 81-8973 (Octocog Alfa; Kovaltry®): A Review in Haemophilia A
Publikationsdatum
01.10.2016
Erschienen in
BioDrugs / Ausgabe 5/2016
Print ISSN: 1173-8804
Elektronische ISSN: 1179-190X
DOI
https://doi.org/10.1007/s40259-016-0191-4