Background
Case presentation
Perihilar cholangiocarcinoma
Patient history
Diagnostics
Treatment
Pathology
Bile duct cholangiocarcinoma
Patient history
Diagnostics
Treatment
Pathology
Molecular pathology
Gene | Exon | Codon | Mutation | Interpretation |
---|---|---|---|---|
BRAF
| 15 | 582–612 | Wildtype | |
DDR2
| 3–18 | 1–342, 351–395, 432–586, 620–856 | Wildtype | |
ERBB2
| 8, 19–21 | 302–321, 761–881 | Wildtype | |
HRAS
| 2–4 | 1–35, 41–82, 105–150 | Wildtype | |
KEAP1
| 2–6 | 1–34, 37–122, 127–437, 443–625 | Wildtype | |
KRAS
| 2–4 | 4–66, 111–150 | Wildtype | |
NFE2L2
| 2 | 16–104 | Wildtype | |
NRAS
| 2–4 | 1–32, 45–83, 110–150 | Wildtype | |
PIK3CA
| 1, 4, 7, 9, 20 | 66–117, 312–350, 418–435, 521–554, 980–1069 | EX20: c.3140A>G p.H1047R | activating |
PTEN
| 1–9 | 1–34, 39–267, 275–333, 343–366 | Wildtype | |
RHOA
| 2, 3 | 3–89 | Wildtype | |
TP53
| 5–9 | 133–260, 263–331 | Wildtype |