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Annals of Nuclear Medicine

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01.11.2015 | Original Article

Biodistribution and estimation of radiation-absorbed doses in humans for ¹³N-ammonia PET

verfasst von: Chang Yi, Donglan Yu, Xinchong Shi, Qiao He, Xuezhen Zhang, Xiangsong Zhang

Erschienen in: Annals of Nuclear Medicine | Ausgabe 9/2015

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Abstract

Objective

To evaluate the biodistribution of radiation-absorbed doses of ¹³N-ammonia in healthy people.

Methods

Five healthy human subjects underwent whole-body PET and CT scans after injection of 555–740 MBq of ¹³N-ammonia. Five serial dynamic emission scans in each healthy volunteer were acquired. Regions of interest were drawn on the CT image and transferred to the corresponding transverse PET slice. Estimates of the radiation-absorbed doses were calculated using the medical internal radiation dosimetry method.

Results

The highest concentrations of ¹³N-ammonia were found in the heart and liver, followed by pancreas, brain, spleen and stomach. The highest absorbed organ doses were to the heart wall (7.14E−03 ± 3.63E−03 mGy/MBq) and kidneys (6.02E−03 ± 3.53E−03 mGy/MBq). The effective dose (ED) was 6.58E−03 ± 1.23E−03 mSv/MBq.

Conclusions

With these new estimates for ¹³N-ammonia dosimetry, the results for Chinese people were not appreciably different from those of the previous study performed with old devices. As one of the most important myocardial perfusion PET tracers, the whole-body ¹³N-ammonia PET appears to be safe for humans, yielding a relatively modest radiation burden that would allow multiple PET studies on the same subject per year.

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Titel: Biodistribution and estimation of radiation-absorbed doses in humans for 13N-ammonia PET
verfasst von: Chang Yi
Donglan Yu
Xinchong Shi
Qiao He
Xuezhen Zhang
Xiangsong Zhang
Publikationsdatum: 01.11.2015
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 9/2015
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-015-1012-4

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Biodistribution and estimation of radiation-absorbed doses in humans for ¹³N-ammonia PET

Abstract

Objective

Methods

Results

Conclusions

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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