Erschienen in:
01.06.2005 | Oral Presentation
Biological features and xenograft models of a very early human premalignant breast lesion
verfasst von:
S Lee, Y Wu, SK Mohsin, D Medina, DC Allred
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
Most breast cancers appear to arise from certain precursors over long periods of time. Enlargement (>50-fold) of normal terminal duct lobular units (TDLUs) by hyperplastic epithelial cells is one of the most common and earliest histologically recognizable alterations with premalignant potential. Understanding how these hyperplastic enlarged lobular units (HELUs) develop and progress could lead to new and effective strategies for breast cancer prevention therapy. …