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International Archives of Occupational and Environmental Health

Erschienen in:

01.03.2011 | Original Article

Biological monitoring for occupational acrylamide exposure from acrylamide production workers

verfasst von: Yu-Fang Huang, Kuen-Yuh Wu, Saou-Hsing Liou, Shi-Nian Uang, Chu-Chih Chen, Wei-Chung Shih, Shih-Chuan Lee, Chih-Chun Jean Huang, Mei-Lien Chen

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 3/2011

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Abstract

Objective

We conducted a repeated-measurement study to (1) investigate the correlation between occupational exposure to airborne acrylamide (AA) and the time-dependent behavior of urinary AAMA, GAMA2, and GAMA3 and (2) calculate the estimated biological exposure index at the permissible exposure limit (PEL) level of 30 μg/m³.

Methods

Forty-four workers were recruited—8 were AA-exposed and 36 were controls. Pre- and post-shift urine samples were collected from the exposed group in parallel with personal sampling for 8 consecutive days and only 1 day for the control group and analyzed using liquid chromatography-electrospray ionization/tandem mass spectrometry (LC–ESI–MS/MS).

Results

Post-shift urinary AAMA level was significantly associated with personal AA exposure (p < 0.001), indicating that urinary AAMA was a better AA exposure biomarker. The estimated urinary excretion of AAMA was 3.0 mg/g creatinine for nonsmoking workers exposed to the PEL of 30 μg/m³. The median GAMA (the sum of GAMA2 and GAMA3)/AAMA ratio for exposed workers was 0.03 (range, 0.005–0.14), relatively lower than that of the nonoccupational group.

Conclusions

Although sample size in this study was small, the repeated-measurement data provide useful reference for future studies related to biological monitoring of occupational exposure to AA.

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Titel: Biological monitoring for occupational acrylamide exposure from acrylamide production workers
verfasst von: Yu-Fang Huang
Kuen-Yuh Wu
Saou-Hsing Liou
Shi-Nian Uang
Chu-Chih Chen
Wei-Chung Shih
Shih-Chuan Lee
Chih-Chun Jean Huang
Mei-Lien Chen
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 3/2011
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-010-0558-7

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Biological monitoring for occupational acrylamide exposure from acrylamide production workers

Abstract

Objective

Methods

Results

Conclusions

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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