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International Archives of Occupational and Environmental Health

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11.01.2017 | Original Article

Biological monitoring of cobalt in hard metal factory workers

verfasst von: Andrea Princivalle, Ivo Iavicoli, Marzia Cerpelloni, Antonia Franceschi, Maurizio Manno, Luigi Perbellini

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 2/2017

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Abstract

Purpose

The main aim of this study was to investigate the cobalt (Co) concentrations in urine along 4 months and their relationship with Co concentrations in blood and haemoglobin (adducts) in 34 workers from a hard metal manufacturing plant where metallic Co and Co oxide were used. Furthermore, the excretion kinetics of Co was investigated and the half-lives of Co in blood, plasma and urine were calculated along 18 days of non-exposure in the same workers.

Methods

Co was analysed, in all biological samples, by ICP/MS.

Results

Wide fluctuations in the urinary Co concentration were observed throughout the work shift and during the work week. A highly significant linear correlation was found between Co concentration (geometrical mean) in urine samples provided each Thursday (end shift) during 16 subsequent weeks and levels of Co-haemoglobin adducts or blood Co concentrations at the end of the same period. The Co elimination kinetics in globin calculated along 18 days without Co exposure was slow, being related to the physiological metabolism of haemoglobin, while in blood, plasma and urine Co half-lives were 12.3, 9.1 and 5.3 days, respectively.

Conclusion

Co concentrations in haemoglobin or blood are highly related to the geometrical mean concentration of urinary Co when samples are collected weekly for several subsequent weeks. The biological monitoring of occupational exposure to Co in hard metal facilities provides reliable results by using the Co concentrations in haemoglobin or in whole blood. The urinary findings, though, do not show the same reliability because of their wide daily and weekly fluctuations.

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Titel: Biological monitoring of cobalt in hard metal factory workers
verfasst von: Andrea Princivalle
Ivo Iavicoli
Marzia Cerpelloni
Antonia Franceschi
Maurizio Manno
Luigi Perbellini
Publikationsdatum: 11.01.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 2/2017
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-016-1190-y

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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