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Rheumatology International
Erschienen in: Rheumatology International 9/2012

01.09.2012 | Review Article

Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review

verfasst von: Boya Nugraha, Matthias Karst, Stefan Engeli, Christoph Gutenbrunner

Erschienen in: Rheumatology International | Ausgabe 9/2012

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Abstract

Fibromyalgia syndrome (FMS) is a common chronic pain condition characterized by chronic widespread pain and decreased pain threshold, with hyperalgesia and allodynia. Associated signs include fatigue, morning stiffness, non-restorative sleep, mood disturbance, depression, irritable bowel syndrome, and headache. In addition to the administration of drugs, psychological therapies treatment of FMS mainly consists of physical therapies. Although the precise pathogenesis of FMS remains elucidated, modern understanding conceptualizes FMS as central sensitization as a consequence of altered endogenous pain- and stress-response system and continuous nociceptive input. Altered brain-derived neurotrophic factor (BDNF) levels in FMS suggest that BDNF—well known for its effects on neuronal plasticity—is involved in this sensitization process. Exercise leads to changes in serum BDNF levels, too. This association highlights the importance of exercise in FMS and other chronic pain conditions.
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Metadaten
Titel
Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review
verfasst von
Boya Nugraha
Matthias Karst
Stefan Engeli
Christoph Gutenbrunner
Publikationsdatum
01.09.2012
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 9/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-011-2348-2

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