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Erschienen in: Journal of Assisted Reproduction and Genetics 11/2011

01.11.2011 | ASSISTED REPRODUCTION TECHNOLOGIES

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

verfasst von: Xue Wang, Zhengyi Sun, Jingran Zhen, Qi Yu

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 11/2011

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Abstract

Purpose

The aim of the study was to evaluate the correlation between BDNF and oocyte maturation and to verify whether BDNF could predict in vitro fertilization (IVF) outcome.

Methods

The follicle fluid (FF) for BDNF, E2 and P assay were obtained from 59 patients undergoing intracytoplasmic sperm injection (ICSI). The women were divided into two groups by pregnancy outcome and their clinical and lab data were compared. And the correlation of BDNF with E2, P, age, and IVF data were analyzed.

Results

Positive correlation was observed between BDNF and E2 concentration in FF. BDNF was positively correlated with the rate of mature oocytes collected and cleavage rate.

Conclusions

The BDNF in FF could not predict IVF outcome, but BDNF in FF might play an important role in the maturation of oocyte and development of oocyte into preimplantation embryo.
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Metadaten
Titel
Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients
verfasst von
Xue Wang
Zhengyi Sun
Jingran Zhen
Qi Yu
Publikationsdatum
01.11.2011
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 11/2011
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-011-9635-4

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