Skip to main content
Erschienen in: Current Breast Cancer Reports 3/2020

28.05.2020 | Breast Cancer Disparities (LA Newman, Section Editor)

Breast Cancer Health Disparities in Hispanics/Latinas

verfasst von: Silvia J. Serrano-Gomez, Maria Carolina Sanabria-Salas, Laura Fejerman

Erschienen in: Current Breast Cancer Reports | Ausgabe 3/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Breast cancer incidence and mortality rates are lower in some Hispanic/Latino subpopulations compared with non-Hispanic White women. However, studies suggest that the risk of breast cancer–specific mortality is higher in USA Hispanics/Latinas. In this review we summarized current knowledge on factors associated with breast cancer incidence and risk of mortality in women of Hispanic/Latino origin.

Recent Findings

Associative studies have proposed a multiplicity of factors likely contributing to differences in breast cancer incidence and survival between population groups, including socioeconomic/sociodemographic factors and lifestyle choices as well as access to and quality of care. Reports of association between global genetic ancestry overall as well as subtype-specific breast cancer risk among Hispanic/Latinas suggest that incidence and subtype distribution could result from differential exposure to environmental and lifestyle-related factors correlated with genetic ancestry as well as germline genetic variation.

Summary

Hispanic/Latinos in the USA have been largely underrepresented in cancer research. It is important to implement inclusive programs that facilitate the access of this population to health services and that also include education programs for the community on the importance of screening. In addition, it is important to continue promoting the inclusion of Hispanics/Latinos in genomic studies that allow understanding the biological behavior of this disease in the context of all human genetic diversity.
Literatur
1.
Zurück zum Zitat • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492This is the most recent report from Globocan on cancer statistics worldwide. CrossRefPubMed • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://​doi.​org/​10.​3322/​caac.​21492This is the most recent report from Globocan on cancer statistics worldwide. CrossRefPubMed
5.
Zurück zum Zitat • Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun. 2014;5:5260. https://doi.org/10.1038/ncomms6260This is the first GWAS of breast cancer in Latinos and reported an Indigenous American–specific protective variant located near theESR1gene. CrossRefPubMed • Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun. 2014;5:5260. https://​doi.​org/​10.​1038/​ncomms6260This is the first GWAS of breast cancer in Latinos and reported an Indigenous American–specific protective variant located near theESR1gene. CrossRefPubMed
6.
Zurück zum Zitat Hoffman J, Fejerman L, Hu D, Hunstman S, Li M, John E, et al. Identification of novel common breast cancer risk variants in Latinas at the 6q25 locus. bioRxiv. 2018. Hoffman J, Fejerman L, Hu D, Hunstman S, Li M, John E, et al. Identification of novel common breast cancer risk variants in Latinas at the 6q25 locus. bioRxiv. 2018.
15.
Zurück zum Zitat G Soares-Souza, V Borda, F Kehdy & E Tarazona-Santos. Admixture, genetics and complex diseases in Latin Americans and US Hispanics. Current Genetic Medicine Reports. 2018. G Soares-Souza, V Borda, F Kehdy & E Tarazona-Santos. Admixture, genetics and complex diseases in Latin Americans and US Hispanics. Current Genetic Medicine Reports. 2018.
21.
Zurück zum Zitat Society AAC. Cancer Facts & Figures for Hispanics/Latinos 2018–2020. 2018. Society AAC. Cancer Facts & Figures for Hispanics/Latinos 2018–2020. 2018.
32.
Zurück zum Zitat • Lynce F, Graves KD, Jandorf L, Ricker C, Castro E, Moreno L, et al. Genomic disparities in breast cancer among Latinas. Cancer Control. 2016;23(4):359–72 Comprehensive review on genomic disparities in breast cancer among Latinas. CrossRefPubMed • Lynce F, Graves KD, Jandorf L, Ricker C, Castro E, Moreno L, et al. Genomic disparities in breast cancer among Latinas. Cancer Control. 2016;23(4):359–72 Comprehensive review on genomic disparities in breast cancer among Latinas. CrossRefPubMed
34.
Zurück zum Zitat • Dutil J, Golubeva VA, Pacheco-Torres AL, Diaz-Zabala HJ, Matta JL, Monteiro AN. The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective. Breast Cancer Res Treat. 2015;154(3):441–53. https://doi.org/10.1007/s10549-015-3629-3Comprehensive description of previous studies reporting on the spectrum of BRCA alleles in Latin America and the Caribbean. CrossRefPubMedPubMedCentral • Dutil J, Golubeva VA, Pacheco-Torres AL, Diaz-Zabala HJ, Matta JL, Monteiro AN. The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective. Breast Cancer Res Treat. 2015;154(3):441–53. https://​doi.​org/​10.​1007/​s10549-015-3629-3Comprehensive description of previous studies reporting on the spectrum of BRCA alleles in Latin America and the Caribbean. CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Weitzel JN, Clague J, Martir-Negron A, Ogaz R, Herzog J, Ricker C, et al. Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network. J Clin Oncol. 2013;31(2):210–6. https://doi.org/10.1200/JCO.2011.41.0027.CrossRefPubMed Weitzel JN, Clague J, Martir-Negron A, Ogaz R, Herzog J, Ricker C, et al. Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network. J Clin Oncol. 2013;31(2):210–6. https://​doi.​org/​10.​1200/​JCO.​2011.​41.​0027.CrossRefPubMed
39.
Zurück zum Zitat • Weitzel JN, Neuhausen SL, Adamson A, Tao S, Ricker C, Maoz A, et al. Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. Cancer. 2019;125(16):2829–36. https://doi.org/10.1002/cncr.32083Description of rare high penetrance mutations among BRCA-negative Hispanics with breast cancer. CrossRefPubMed • Weitzel JN, Neuhausen SL, Adamson A, Tao S, Ricker C, Maoz A, et al. Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. Cancer. 2019;125(16):2829–36. https://​doi.​org/​10.​1002/​cncr.​32083Description of rare high penetrance mutations among BRCA-negative Hispanics with breast cancer. CrossRefPubMed
40.
Zurück zum Zitat Keegan TH, John EM, Fish KM, Alfaro-Velcamp T, Clarke CA, Gomez SL. Breast cancer incidence patterns among California Hispanic women: differences by nativity and residence in an enclave. Cancer Epidemiol Biomarkers Prevent : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(5):1208–18. https://doi.org/10.1158/1055-9965.EPI-10-0021.CrossRef Keegan TH, John EM, Fish KM, Alfaro-Velcamp T, Clarke CA, Gomez SL. Breast cancer incidence patterns among California Hispanic women: differences by nativity and residence in an enclave. Cancer Epidemiol Biomarkers Prevent : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(5):1208–18. https://​doi.​org/​10.​1158/​1055-9965.​EPI-10-0021.CrossRef
42.
Zurück zum Zitat • Pinheiro PS, Sherman RL, Trapido EJ, Fleming LE, Huang Y, Gomez-Marin O, et al. Cancer incidence in first generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and new Latinos. Cancer Epidemiol Biomark Prev. 2009;18(8):2162–9. https://doi.org/10.1158/1055-9965.EPI-09-0329Showed how cancer rates vary among Hispanic subpopulations by country of origin and immigration status. CrossRef • Pinheiro PS, Sherman RL, Trapido EJ, Fleming LE, Huang Y, Gomez-Marin O, et al. Cancer incidence in first generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and new Latinos. Cancer Epidemiol Biomark Prev. 2009;18(8):2162–9. https://​doi.​org/​10.​1158/​1055-9965.​EPI-09-0329Showed how cancer rates vary among Hispanic subpopulations by country of origin and immigration status. CrossRef
43.
62.
Zurück zum Zitat Society AC. Breast Cancer Facts & Figures 2017–2018. 2017. Society AC. Breast Cancer Facts & Figures 2017–2018. 2017.
66.
Zurück zum Zitat Clarke TC, Endeshaw M, Duran D, Saraiya M. Breast cancer screening among women by nativity, birthplace, and length of time in the United States. Natl Health Stat Report. 2019;129:1–15. Clarke TC, Endeshaw M, Duran D, Saraiya M. Breast cancer screening among women by nativity, birthplace, and length of time in the United States. Natl Health Stat Report. 2019;129:1–15.
78.
Zurück zum Zitat Jara Sánchez C, Ruiz A, Martín M, Antón A, Munárriz B, Plazaola A, et al. Influence of timing of initiation of adjuvant chemotherapy over survival in breast cancer: a negative outcome study by the Spanish Breast Cancer Research Group (GEICAM). Breast Cancer Res Treat. 2007;101(2):215–23. https://doi.org/10.1007/s10549-006-9282-0.CrossRefPubMed Jara Sánchez C, Ruiz A, Martín M, Antón A, Munárriz B, Plazaola A, et al. Influence of timing of initiation of adjuvant chemotherapy over survival in breast cancer: a negative outcome study by the Spanish Breast Cancer Research Group (GEICAM). Breast Cancer Res Treat. 2007;101(2):215–23. https://​doi.​org/​10.​1007/​s10549-006-9282-0.CrossRefPubMed
81.
Zurück zum Zitat Colleoni M, Bonetti M, Coates AS, Castiglione-Gertsch M, Gelber RD, Price K, et al. Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group. J Clin Oncol. 2000;18(3):584–90. https://doi.org/10.1200/JCO.2000.18.3.584.CrossRefPubMed Colleoni M, Bonetti M, Coates AS, Castiglione-Gertsch M, Gelber RD, Price K, et al. Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group. J Clin Oncol. 2000;18(3):584–90. https://​doi.​org/​10.​1200/​JCO.​2000.​18.​3.​584.CrossRefPubMed
91.
Zurück zum Zitat Warnecke RB, Campbell RT, Vijayasiri G, Barrett RE, Rauscher GH. Multilevel examination of health disparity: the role of policy implementation in neighborhood context, in patient resources, and in healthcare facilities on later stage of breast cancer diagnosis. Cancer Epidemiol Biomark Prev. 2019;28(1):59–66. https://doi.org/10.1158/1055-9965.EPI-17-0945.CrossRef Warnecke RB, Campbell RT, Vijayasiri G, Barrett RE, Rauscher GH. Multilevel examination of health disparity: the role of policy implementation in neighborhood context, in patient resources, and in healthcare facilities on later stage of breast cancer diagnosis. Cancer Epidemiol Biomark Prev. 2019;28(1):59–66. https://​doi.​org/​10.​1158/​1055-9965.​EPI-17-0945.CrossRef
97.
Zurück zum Zitat Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, et al. Basal-like subtype of invasive breast carcinoma immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 2004;10:5367–74.CrossRefPubMed Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, et al. Basal-like subtype of invasive breast carcinoma immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 2004;10:5367–74.CrossRefPubMed
100.
Zurück zum Zitat Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. J Am Med Assoc. 2006;295(21):2492–502.CrossRef Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. J Am Med Assoc. 2006;295(21):2492–502.CrossRef
102.
Zurück zum Zitat Fejerman L, Serrano-Gómez S.J, Tamayo L. Breast cancer risk and mortality in women of Latin American Origin. In: Trapido AGREJ, editor. Advancing the Science of Cancer in Latinos Springer Open; 2020. Fejerman L, Serrano-Gómez S.J, Tamayo L. Breast cancer risk and mortality in women of Latin American Origin. In: Trapido AGREJ, editor. Advancing the Science of Cancer in Latinos Springer Open; 2020.
104.
105.
Zurück zum Zitat • Marker KM, Zavala VA, Vidaurre T, Lott PC, Vásquez JN, Casavilca-Zambrano S, et al. Human epidermal growth factor receptor 2–positive breast cancer is associated with Indigenous American ancestry in Latin American Women. Cancer Res. 2020. https://doi.org/10.1158/0008-5472.can-19-3659This study reported for the first time an association between Indigenous American ancestry and an increased risk for HER2-positive tumors in Latina women. • Marker KM, Zavala VA, Vidaurre T, Lott PC, Vásquez JN, Casavilca-Zambrano S, et al. Human epidermal growth factor receptor 2–positive breast cancer is associated with Indigenous American ancestry in Latin American Women. Cancer Res. 2020. https://​doi.​org/​10.​1158/​0008-5472.​can-19-3659This study reported for the first time an association between Indigenous American ancestry and an increased risk for HER2-positive tumors in Latina women.
Metadaten
Titel
Breast Cancer Health Disparities in Hispanics/Latinas
verfasst von
Silvia J. Serrano-Gomez
Maria Carolina Sanabria-Salas
Laura Fejerman
Publikationsdatum
28.05.2020
Verlag
Springer US
Erschienen in
Current Breast Cancer Reports / Ausgabe 3/2020
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-020-00370-3

Weitere Artikel der Ausgabe 3/2020

Current Breast Cancer Reports 3/2020 Zur Ausgabe

Breast Cancer Disparities (LA Newman, Section Editor)

Large Datasets for Disparities Research in Breast Cancer

Breast Cancer Disparities (LA Newman, Section Editor)

Breast Reconstruction Disparities in the United States and Internationally

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.