The online version of this article (doi:10.1186/1752-1947-6-217) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
GB and RF were responsible for interpretation of the case report. ELM, MDB, and MD were responsible for provision of study materials or details regarding our patient. MC, GL, ADC, GL and RF collected and assembled data and samples for FISH and immunohistochemical analysis. MC was responsible for PCR clonality analysis. EML, MDB and ADC were responsible for immunohistochemical evaluation. GL and RF were responsible for FISH evaluation. All authors were involved in manuscript writing and provided final approval for the manuscript.
Breast involvement by non-Hodgkin lymphoma is particularly rare in men. We describe the case of a patient with a rapidly growing, painless gynecomastia-like nodule in the left breast. On ultrasonography, the nodule was suspicious for breast carcinoma.
A breast biopsy from a 54-year-old Caucasian man showed the morphoimmunophenotypical features of grade 3 follicular lymphoma. Moreover, fluorescence in situ hybridization analysis showed a t(14,18) translocation suggesting breast involvement by a systemic lymphoma rather than a primary breast lymphoma. The histological diagnosis was subsequently confirmed after nodule excision. Mediastinal and abdominal node involvement was then identified on computed tomography and positron emission tomography scans during staging examinations. Our patient was treated with chemotherapy. After three years our patient experienced a right retro-areolar relapse. He then received two further cycles of chemotherapy but developed a myeloid acute leukemia and, as a result of this, he subsequently died.
The rarity of breast lymphomas, especially in men, and the problems related to the therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.
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