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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

Journal of Medical Case Reports 1/2012

Breast systemic follicular lymphoma in a man: a case report

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2012
Autoren:
Elvira La Mantia, Monica Cantile, Giuseppina Liguori, Maurizio Di Bonito, Annarosaria De Chiara, Massimiliano D'Aiuto, Giuseppe Pannone, Renato Franco, Gerardo Botti
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-6-217) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

GB and RF were responsible for interpretation of the case report. ELM, MDB, and MD were responsible for provision of study materials or details regarding our patient. MC, GL, ADC, GL and RF collected and assembled data and samples for FISH and immunohistochemical analysis. MC was responsible for PCR clonality analysis. EML, MDB and ADC were responsible for immunohistochemical evaluation. GL and RF were responsible for FISH evaluation. All authors were involved in manuscript writing and provided final approval for the manuscript.

Abstract

Introduction

Breast involvement by non-Hodgkin lymphoma is particularly rare in men. We describe the case of a patient with a rapidly growing, painless gynecomastia-like nodule in the left breast. On ultrasonography, the nodule was suspicious for breast carcinoma.

Case presentation

A breast biopsy from a 54-year-old Caucasian man showed the morphoimmunophenotypical features of grade 3 follicular lymphoma. Moreover, fluorescence in situ hybridization analysis showed a t(14,18) translocation suggesting breast involvement by a systemic lymphoma rather than a primary breast lymphoma. The histological diagnosis was subsequently confirmed after nodule excision. Mediastinal and abdominal node involvement was then identified on computed tomography and positron emission tomography scans during staging examinations. Our patient was treated with chemotherapy. After three years our patient experienced a right retro-areolar relapse. He then received two further cycles of chemotherapy but developed a myeloid acute leukemia and, as a result of this, he subsequently died.

Conclusions

The rarity of breast lymphomas, especially in men, and the problems related to the therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.

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Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Literatur
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