Erschienen in:
01.09.2012
Ca2+ Signaling in Cerebellar Purkinje Neurons—Editorial
verfasst von:
Donna Gruol, Mario Manto, Duane Haines
Erschienen in:
The Cerebellum
|
Ausgabe 3/2012
Einloggen, um Zugang zu erhalten
Abstract
Tight regulation of calcium (Ca2+) dynamics is critical for all neurons. Ca2+ is a major mediator of cellular excitability, synaptic plasticity, and regulation of transcription, amongst others. Recent years have seen major developments in terms of understanding the roles of Ca2+ signals in the cerebellar circuitry, especially for Purkinje neurons and granule cells. The unique morphology of Purkinje neurons serves as a platform to unravel the secrets of Ca2+ homeostasis in cerebellar microcircuits. This special issue covers recent advances in Ca2+ signaling and imaging, and highlights the importance of spatiotemporal compartmentalization underlying Ca2+ dynamics. Sorting out the pieces of the puzzle of homeostatic regulation of Ca2+ remains an instrumental step to start rational therapies of Ca2+ deregulation.