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01.02.2016 | Cardiac Nuclear Imaging (A. Cuocolo, Section Editor)

Cardiac Innervation Imaging: Implications for Risk Stratification and Therapeutic Decision-Making

verfasst von: Albert Flotats, Ignasi Carrió

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 2/2016

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Abstract

Heart failure (HF) is associated with reduced cardiac sympathetic neuronal uptake of norepinephrine (NE), which can be assessed noninvasively using different radiotracers and planar or single-photon emission computed tomography (SPECT)/positron emission tomography (PET) imaging. Such sympathetic derangement in HF patients has shown to be an indicator of unfavorable prognosis. Therefore, cardiac sympathetic imaging might be useful as an indicator of the effectiveness of the medical therapy and consequently for risk stratification of patients with HF to more effectively guide specific therapies. This article reviews the current status on the subject and evaluates the literature published over recent years.
Literatur
1.
Zurück zum Zitat Jacobson AF, Narula J. Introduction to cardiac neuronal imaging: a clinical perspective. J Nucl Med. 2015;56:3S–6.CrossRefPubMed Jacobson AF, Narula J. Introduction to cardiac neuronal imaging: a clinical perspective. J Nucl Med. 2015;56:3S–6.CrossRefPubMed
2.
Zurück zum Zitat Nakajima K, Nakata T. Cardiac 123I-MIBG imaging for clinical decision making: 22-year experience in Japan. J Nucl Med. 2015;56:11S–9.CrossRefPubMed Nakajima K, Nakata T. Cardiac 123I-MIBG imaging for clinical decision making: 22-year experience in Japan. J Nucl Med. 2015;56:11S–9.CrossRefPubMed
3.
Zurück zum Zitat Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212–21.CrossRefPubMed Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212–21.CrossRefPubMed
4.
Zurück zum Zitat Petretta M, Pellegrino T, Cuocolo A. Cardiac neuronal imaging with 123I-meta-iodobenzylguanidine in heart failure: implications of endpoint selection and quantitative analysis on clinical decisions. Eur J Nucl Med Mol Imaging. 2014;41:1663–5.CrossRefPubMed Petretta M, Pellegrino T, Cuocolo A. Cardiac neuronal imaging with 123I-meta-iodobenzylguanidine in heart failure: implications of endpoint selection and quantitative analysis on clinical decisions. Eur J Nucl Med Mol Imaging. 2014;41:1663–5.CrossRefPubMed
5.
Zurück zum Zitat Ketchum ES, Jacobson AF, Caldwell JH, Senior R, Cerqueira MD, Thomas GS, et al. Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging. J Nucl Cardiol. 2012;19:1007–16.CrossRefPubMed Ketchum ES, Jacobson AF, Caldwell JH, Senior R, Cerqueira MD, Thomas GS, et al. Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging. J Nucl Cardiol. 2012;19:1007–16.CrossRefPubMed
6.
Zurück zum Zitat Levy WC, Lee KL, Hellkamp AS, Poole JE, Mozaffarian D, Linker DT, et al. Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population. Circulation. 2009;120:835–42.PubMedCentralCrossRefPubMed Levy WC, Lee KL, Hellkamp AS, Poole JE, Mozaffarian D, Linker DT, et al. Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population. Circulation. 2009;120:835–42.PubMedCentralCrossRefPubMed
7.••
Zurück zum Zitat Narula J, Gerson M, Thomas GS, Cerqueira MD, Jacobson AF. 123I-MIBG imaging for prediction of mortality and potentially fatal events in heart failure: the ADMIRE-HFX study. J Nucl Med. 2015;56:1011–8. Demonstration of 123 I-mIBG late HMR as independent prognostic marker, additive to currently available risk stratification procedures. Narula J, Gerson M, Thomas GS, Cerqueira MD, Jacobson AF. 123I-MIBG imaging for prediction of mortality and potentially fatal events in heart failure: the ADMIRE-HFX study. J Nucl Med. 2015;56:1011–8. Demonstration of 123 I-mIBG late HMR as independent prognostic marker, additive to currently available risk stratification procedures.
8.
Zurück zum Zitat Parker MW, Sood N, Ahlberg AW, Jacobson AF, Heller GV, et al. Relationship between quantitative cardiac neuronal imaging with 123I-meta-iodobenzylguanidine and hospitalization in patients with heart failure. Eur J Nucl Med Mol Imaging. 2014;41:1666–72.CrossRefPubMed Parker MW, Sood N, Ahlberg AW, Jacobson AF, Heller GV, et al. Relationship between quantitative cardiac neuronal imaging with 123I-meta-iodobenzylguanidine and hospitalization in patients with heart failure. Eur J Nucl Med Mol Imaging. 2014;41:1666–72.CrossRefPubMed
9.
Zurück zum Zitat Clements IP, Kelkar AA, Garcia EV, Butler J, Chen J, Folks R, et al. Prognostic significance of 123I-mIBG SPECT myocardial imaging in heart failure: differences between patients with ischaemic and non-ischaemic heart failure. Eur Heart J Cardiovasc Imaging 2015. doi:10.1093/ehjci/jev295. Clements IP, Kelkar AA, Garcia EV, Butler J, Chen J, Folks R, et al. Prognostic significance of 123I-mIBG SPECT myocardial imaging in heart failure: differences between patients with ischaemic and non-ischaemic heart failure. Eur Heart J Cardiovasc Imaging 2015. doi:10.​1093/​ehjci/​jev295.
10.
Zurück zum Zitat Clements IP, Chen J, Folks R, Butler J, Jacobson AF. Quantitative iodine 123 meta-iodobenzylguanidine (123I mIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: development and validation of automated procedures in conjunction with technetium-99 m tetrofosmin myocardial perfusion SPECT. J Nucl Cardiol 2015. doi:10.1007/s12350-015-0097-4. Clements IP, Chen J, Folks R, Butler J, Jacobson AF. Quantitative iodine 123 meta-iodobenzylguanidine (123I mIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: development and validation of automated procedures in conjunction with technetium-99 m tetrofosmin myocardial perfusion SPECT. J Nucl Cardiol 2015. doi:10.​1007/​s12350-015-0097-4.
11.
Zurück zum Zitat Shah AM, Bourgoun M, Narula J, Jacobson AF, Solomon SD. Influence of ejection fraction on the prognostic value of sympathetic innervation imaging with Iodine-123 MIBG in heart failure. J Am Coll Cardiol Img. 2012;5:1139–46.CrossRef Shah AM, Bourgoun M, Narula J, Jacobson AF, Solomon SD. Influence of ejection fraction on the prognostic value of sympathetic innervation imaging with Iodine-123 MIBG in heart failure. J Am Coll Cardiol Img. 2012;5:1139–46.CrossRef
12.
Zurück zum Zitat Sood N, Al Badarin F, Parker M, Pullatt R, Jacobson AF, Bateman TM, et al. Resting perfusion MPI-SPECT combined with cardiac 123I-mIBG sympathetic innervation imaging improves prediction of arrhythmic events in non-ischemic cardiomyopathy patients: sub-study from the ADMIRE-HF trial. J Nucl Cardiol. 2013;20:813–20.CrossRefPubMed Sood N, Al Badarin F, Parker M, Pullatt R, Jacobson AF, Bateman TM, et al. Resting perfusion MPI-SPECT combined with cardiac 123I-mIBG sympathetic innervation imaging improves prediction of arrhythmic events in non-ischemic cardiomyopathy patients: sub-study from the ADMIRE-HF trial. J Nucl Cardiol. 2013;20:813–20.CrossRefPubMed
13.
Zurück zum Zitat Al Badarin FJ, Wimmer AP, Kennedy KF, Jacobson AF, Bateman TM. The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: incremental prognostic benefit of cardiac 123I-mIBG scintigraphy. J Nucl Cardiol. 2014;21:756–62.CrossRefPubMed Al Badarin FJ, Wimmer AP, Kennedy KF, Jacobson AF, Bateman TM. The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: incremental prognostic benefit of cardiac 123I-mIBG scintigraphy. J Nucl Cardiol. 2014;21:756–62.CrossRefPubMed
14.
Zurück zum Zitat Saba S, Aban I, Soman P. 123I-mIBG scintigraphy: yet another risk stratifier for the heart failure toolbox! J Nucl Cardiol. 2014;21:909–12.CrossRefPubMed Saba S, Aban I, Soman P. 123I-mIBG scintigraphy: yet another risk stratifier for the heart failure toolbox! J Nucl Cardiol. 2014;21:909–12.CrossRefPubMed
15.
Zurück zum Zitat JCS Joint Working Group. Guidelines for clinical use of cardiac nuclear medicine (JCS 2010) – digest version –. Circ J. 2012;76:761–7.CrossRef JCS Joint Working Group. Guidelines for clinical use of cardiac nuclear medicine (JCS 2010) – digest version –. Circ J. 2012;76:761–7.CrossRef
16.
Zurück zum Zitat Nakata T, Nakajima K, Yamashina S, Yamada T, Momose M, Kasama S, et al. A pooled analysis of multicenter cohort studies of 123I-MIBG-imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6:772–84.CrossRefPubMed Nakata T, Nakajima K, Yamashina S, Yamada T, Momose M, Kasama S, et al. A pooled analysis of multicenter cohort studies of 123I-MIBG-imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6:772–84.CrossRefPubMed
17.
Zurück zum Zitat Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, et al. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol. 2014;21:970–8.PubMedCentralCrossRefPubMed Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, et al. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol. 2014;21:970–8.PubMedCentralCrossRefPubMed
18.
Zurück zum Zitat Nakajima K, Nakata T, Yamada T, Yamashina S, Momose M, Kasama S, et al. A prediction model for 5-year cardiac mortality in patients with chronic heart failure using 123I-metaiodobenzylguanidine imaging. Eur J Nucl Med Mol Imaging. 2014;41:1673–82.PubMedCentralCrossRefPubMed Nakajima K, Nakata T, Yamada T, Yamashina S, Momose M, Kasama S, et al. A prediction model for 5-year cardiac mortality in patients with chronic heart failure using 123I-metaiodobenzylguanidine imaging. Eur J Nucl Med Mol Imaging. 2014;41:1673–82.PubMedCentralCrossRefPubMed
19.••
Zurück zum Zitat Nakajima K, Nakata T, Matsuo T, Jacobson AF. Creation of mortality risk charts using 123I meta-iodobenzylguanidine heart-to-mediastinum ratio in patients with heart failure: two- and five year risk models. Eur Heart J Cardiovasc Imaging 2015. doi:10.1093/ehjci/jev322. Creation of clinically useful mortality risk charts with three common clinical variables including age, NYHA class and LVEF, together with 123 I-mIBG late HMR for prognostic stratification in heart failure patients. Nakajima K, Nakata T, Matsuo T, Jacobson AF. Creation of mortality risk charts using 123I meta-iodobenzylguanidine heart-to-mediastinum ratio in patients with heart failure: two- and five year risk models. Eur Heart J Cardiovasc Imaging 2015. doi:10.​1093/​ehjci/​jev322. Creation of clinically useful mortality risk charts with three common clinical variables including age, NYHA class and LVEF, together with 123 I-mIBG late HMR for prognostic stratification in heart failure patients.
20.
Zurück zum Zitat Fallavollita JA, Heavey BM, Luisi Jr AJ, Michalek SM, Baldwa S, Mashtare Jr TL, et al. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141–9.PubMedCentralCrossRefPubMed Fallavollita JA, Heavey BM, Luisi Jr AJ, Michalek SM, Baldwa S, Mashtare Jr TL, et al. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141–9.PubMedCentralCrossRefPubMed
21.••
Zurück zum Zitat Verschure DO, Veltman CE, Manrique A, Somsen GA, Koutelou M, Katsikis A, et al. For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis. Eur Heart J Cardiovasc Imaging. 2014;15:996–1003. A meta-analysis showing the intermediate to long-term prognostic value of 123 I-mIBG late HMR. Verschure DO, Veltman CE, Manrique A, Somsen GA, Koutelou M, Katsikis A, et al. For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis. Eur Heart J Cardiovasc Imaging. 2014;15:996–1003. A meta-analysis showing the intermediate to long-term prognostic value of 123 I-mIBG late HMR.
22.
Zurück zum Zitat Boogers MJ, Borleffs CJ, Henneman MM, van Bommel RJ, Boersma E, et al. Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter defibrillator patients. J Am Coll Cardiol. 2010;55:2769–77.CrossRefPubMed Boogers MJ, Borleffs CJ, Henneman MM, van Bommel RJ, Boersma E, et al. Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter defibrillator patients. J Am Coll Cardiol. 2010;55:2769–77.CrossRefPubMed
23.
Zurück zum Zitat Bax JJ, Kraft O, Buxton AE, Fjeld JG, Parizek P, Agostini D, et al. 123 I-MIBG scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing: a prospective multicenter pilot study. Circ Cardiovasc Imaging. 2008;1:131–40.CrossRefPubMed Bax JJ, Kraft O, Buxton AE, Fjeld JG, Parizek P, Agostini D, et al. 123 I-MIBG scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing: a prospective multicenter pilot study. Circ Cardiovasc Imaging. 2008;1:131–40.CrossRefPubMed
24.
Zurück zum Zitat Wessler BS, Udelson JE. Neuronal dysfunction and medical therapy in heart failure: can an imaging biomarker help to “personalize” therapy? J Nucl Med. 2015;56:20S–4.CrossRefPubMed Wessler BS, Udelson JE. Neuronal dysfunction and medical therapy in heart failure: can an imaging biomarker help to “personalize” therapy? J Nucl Med. 2015;56:20S–4.CrossRefPubMed
Metadaten
Titel
Cardiac Innervation Imaging: Implications for Risk Stratification and Therapeutic Decision-Making
verfasst von
Albert Flotats
Ignasi Carrió
Publikationsdatum
01.02.2016
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 2/2016
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-015-9368-3

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