nach oben

Inflammation

Erschienen in:

01.03.2019 | ORIGINAL ARTICLE

Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells

verfasst von: Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Takashi Matsuo

Erschienen in: Inflammation | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Carnosic acid, which is a bioactive compound isolated from rosemary, has various pharmacological effects. However, the anti-inflammatory effect of carnosic acid on periodontitis is still unknown. The aim of this study was to investigate the effect of carnosic acid on CXC chemokine receptor 3 (CXCR3) ligands, which are involved in Th1 cells migration and accumulation, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). Carnosic acid decreased CXC chemokine ligand (CXCL)9, CXCL10, and CXCL11 production in IL-27-stimulated TR146 cells in a dose-dependent fashion. Moreover, we disclosed that carnosic acid could suppress signal transducer and activator of transcription (STAT)1, STAT3, and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells. Furthermore, STAT1, STAT3, and Akt inhibitors could suppress CXCR3 ligands production in IL-27-treated TR146 cells. In summary, carnosic acid could reduce CXCR3 ligands production in human oral epithelial cell by inhibiting STAT1, STAT3, and Akt activation.

Page, R.C. 1991. The role of inflammatory mediators in the pathogenesis of periodontal disease. Journal of Periodontal Research 26: 230–242.CrossRefPubMed

Kawai, T., R. Eisen-Lev, M. Seki, J.W. Eastcott, M.E. Wilson, and M.A. Taubman. 2000. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. Journal of Immunology 64: 2102–2109.CrossRef

Zhang, X., and Y.T. Teng. 2006. Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappaB ligand-positive CD4+-Th1-cell-associated alveolar bone loss in vivo. Infection and Immunity 74: 4927–4931.CrossRefPubMedPubMedCentral

Hienz, S.A., S. Paliwal, and S. Ivanovski. 2015. Mechanisms of bone resorption in periodontitis. Journal of Immunology Research 2015: 615486.CrossRefPubMedPubMedCentral

Heise, C.E., A. Pahuja, S.C. Hudson, M.S. Mistry, A.L. Putnam, M.M. Gross, P.A. Gottlieb, W.S. Wade, M. Kiankarimi, D. Schwarz, P. Crowe, A. Zlotnik, and D.G. Alleva. 2005. Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. The Journal of Pharmacology and Experimental Therapeutics 313: 1263–1271.CrossRefPubMed

Hosokawa, Y., I. Hosokawa, K. Ozaki, and T. Matsuo. 2017. IL-27 modulates chemokine production in TNF-α -stimulated human oral epithelial cells. Cellular Physiology and Biochemistry 43: 1198–1206.CrossRefPubMed

Thummuri, D., V.G.M. Naidu, and P. Chaudhari. 2017. Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling. Journal of Molecular Medicine 95: 1065–1076.CrossRefPubMed

Vázquez, N.M., G. Fiorilli, P.A. Cáceres Guido, and S. Moreno. 2016. Carnosic acid acts synergistically with gentamicin in killing methicillin-resistant Staphylococcus aureus clinical isolates. Phytomedicine. 23: 1337–1343.CrossRefPubMed

Su, K., C.F. Wang, Y. Zhang, Y.J. Cai, Y.Y. Zhang, and Q. Zhao. 2016. The inhibitory effects of carnosic acid on cervical cancer cells growth by promoting apoptosis via ROS-regulated signaling pathway. Biomedicine & Pharmacotherapy 82: 180–191.CrossRef

10.

Gaya, M., V. Repetto, J. Toneatto, C. Anesini, G. Piwien-Pilipuk, and S. Moreno. 2013. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. Biochimica et Biophysica Acta 1830: 3796–3806.

11.

Jacobsen, J., E.B. Nielsen, K. Brøndum-Nielsen, M.E. Christensen, H.B. Olin, N. Tommerup, and M.R. Rassing. 1999. Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability. European Journal of Oral Sciences 107: 138–146.CrossRefPubMed

12.

Garlet, G.P., W. Martins Jr., B.R. Ferreira, C.M. Milanezi, and J.S. Silva. 2003. Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. Journal of Periodontal Research 38: 210–217.CrossRefPubMed

13.

Hosokawa, Y., I. Hosokawa, K. Ozaki, and T. Matsuo. 2018. Honokiol and magnolol inhibit CXCL10 and CXCL11 production in IL-27-stimulated human oral epithelial cells. Inflammation 41: 2110–2115.CrossRefPubMed

14.

Hosokawa, Y., I. Hosokawa, K. Ozaki, H. Nakae, and T. Matsuo. 2009 Apr. Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts. Journal of Periodontal Research 44 (2): 225–231.CrossRefPubMed

15.

Hosokawa, Y., I. Hosokawa, K. Ozaki, H. Nakae, and T. Matsuo. 2010. TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts. Molecular Immunology 47: 666–670.CrossRefPubMed

16.

Hosokawa, Y., I. Hosokawa, K. Ozaki, T. Nakanishi, H. Nakae, and T. Matsuo. 2010 Jul. Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts. The Journal of Nutritional Biochemistry 21 (7): 659–664.CrossRefPubMed

17.

Liu, M., X. Zhou, L. Zhou, Z. Liu, J. Yuan, J. Cheng, J. Zhao, L. Wu, H. Li, H. Qiu, and J. Xu. 2018. Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats. Journal of Cellular Physiology 233: 6291–6303.CrossRefPubMed

18.

Kida, Y., M. Kobayashi, T. Suzuki, A. Takeshita, Y. Okamatsu, S. Hanazawa, T. Yasui, and K. Hasegawa. 2005. Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts. Cytokine. 29: 159–168.CrossRefPubMed

19.

Rizzo, A., N. Bevilacqua, L. Guida, M. Annunziata, C. Romano Carratelli, and R. Paolillo. 2012. Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells. Cytokine. 60: 197–204.CrossRefPubMed

20.

Kim, D.H., K.W. Park, I.G. Chae, J. Kundu, E.H. Kim, J.K. Kundu, and K.S. Chun. 2016. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular Carcinogenesis 55: 1096–1110.CrossRefPubMed

21.

Kar, S., S. Palit, W.B. Ball, and P.K. Das. 2012. Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis. 17: 735–747.CrossRefPubMed

Titel: Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells
verfasst von: Ikuko Hosokawa
Yoshitaka Hosokawa
Kazumi Ozaki
Takashi Matsuo
Publikationsdatum: 01.03.2019
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 4/2019
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-019-00991-6

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2019

Curcumin Modulates Paraquat-Induced Epithelial to Mesenchymal Transition by Regulating Transforming Growth Factor-β (TGF-β) in A549 Cells

Correction to: miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis

Correction to: Plumbagin Prevents IL-1β-Induced Inflammatory Response in Human Osteoarthritis Chondrocytes and Prevents the Progression of Osteoarthritis in Mice

α7nAChR Deletion Aggravates Myocardial Infarction and Enhances Systemic Inflammatory Reaction via mTOR-Signaling-Related Autophagy

Probucol Ameliorates Complete Freund’s Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation

Regulatory T Cells Could Improve Intestinal Barrier Dysfunction in Heatstroke

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin