Background
Methods
Study design and setting
Data collection
Statistical methods
Results
Description of cohort
Initiation of ART
ART Initiation During Pregnancy
N = 1986 | ART Initiation During Breastfeeding
N = 969 |
P-value | |
---|---|---|---|
Age | |||
< 30 years | 1293 (65.4 %) | 565 (58.5 %) | < 0.001 |
> 30 years | 685 (34.6 %) | 401 (41.5 %) | |
Health Facility Sizea
| |||
Small (< 100) | 45 (2.3 %) | 29 (3.0 %) | 0.06 |
Medium (100–500) | 1674 (84.3 %) | 836 (86.3 %) | |
Large (> 500) | 267 (13.4 %) | 104 (10.7 %) | |
WHO Clinical Stage at Initiation | |||
Stage 1 | 1241 (62.5 %) | 536 (55.3 %) | < 0.001 |
Stage 2 | 119 (6.0 %) | 87 (9.0 %) | |
Stage 3–4 | 75 (3.8 %) | 95 (9.8 %) | |
Not documented | 551 (27.7 %) | 251 (25.9 %) | |
Adherence Rates | |||
> 95 % | 1330 (97.4 %) | 766 (98.3 %) | 0.18 |
< 95 % | 35 (2.6 %) | 13 (1.7 %) |
Unadjusted Odds Ratios | Adjusted Odds Ratios | |||||
---|---|---|---|---|---|---|
OR | 95 % CI |
P-value | aOR | 95 % CI |
P-value | |
Age | ||||||
< 30 years | --- | --- | --- | --- | --- | --- |
> 30 years | 1.34 | 1.14, 1.57 | < 0.001 | 1.33 | 1.11, 1.59 | 0.003 |
Health Facility Sizea
| ||||||
Small (< 100) | --- | --- | --- | --- | --- | --- |
Medium (100–500) | 0.78 | 0.48, 1.25 | 0.29 | 0.78 | 0.45, 1.35 | 0.37 |
Large (> 500) | 0.60 | 0.36, 1.02 | 0.06 | 0.65 | 0.36, 1.17 | 0.15 |
WHO Clinical Stage at Initiation | ||||||
Stage 1 | --- | --- | --- | --- | --- | --- |
Stage 2 | 1.69 | 1.26, 2.27 | < 0.001 | 1.59 | 1.15, 2.18 | 0.005 |
Stage 3–4 | 2.93 | 2.13, 4.03 | < 0.001 | 2.74 | 1.94, 3.87 | < 0.001 |
Not documented | 1.06 | 0.88, 1.26 | 0.56 | 1.18 | 0.95, 1.47 | 0.14 |
Adherence Rates | ||||||
= > 95 % | --- | --- | --- | --- | --- | --- |
< 95 % | 1.55 | 0.82, 2.95 | 0.18 | 1.50 | 0.78, 2.88 | 0.22 |
Death or treatment default
Unadjusted Odds Ratios | Adjusted Odds Ratios | |||||
---|---|---|---|---|---|---|
OR | 95 % CI |
P-value | aOR | 95 % CI |
P-value | |
Timing of ART Initiation | ||||||
In Pregnancy | 1.72 | 1.37, 2.17 | < 0.001 | 1.62 | 1.28, 2.05 | < 0.001 |
In Breastfeeding | --- | |||||
Age | ||||||
< 30 years | 1.33 | 1.07, 1.65 | 0.01 | 1.27 | 1.02, 1.57 | 0.03 |
> 30 years | --- | |||||
Health Facility Size | ||||||
Small (< 100) | --- | --- | --- | |||
Medium (100–500) | 1.00 | 0.52, 1.92 | 0.99 | |||
Large (> 500) | 1.19 | 0.59, 2.41 | 0.62 | |||
WHO Clinical Stage at Initiation | ||||||
Stage 1 | --- | --- | --- | --- | --- | --- |
Stage 2 | 0.58 | 0.37, 0.92 | 0.02 | 0.62 | 0.39, 0.98 | 0.04 |
Stage 3–4 Not documented | 0.26 1.15 | 0.13, 0.52 0.91, 1.47 | < 0.001 0.24 | 0.30 1.18 | 0.15, 0.60 0.93, 1.50 | < 0.001 0.18 |