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Journal of Natural Medicines

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01.04.2012 | Review

Chemical and pharmacological studies of Oplopanax horridus, a North American botanical

verfasst von: Tyler Calway, Guang-Jian Du, Chong-Zhi Wang, Wei-Hua Huang, Jing Zhao, Shao-Ping Li, Chun-Su Yuan

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2012

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Abstract

Oplopanax horridus (OH), or Devil’s club, is an ethnobotanical used by the indigenous people native to the Pacific Northwest of North America. There are three species in the genus Oplopanax, and OH is the only species that is distributed in North America. Compared with the extensive research on OH’s “cousin,” American ginseng, there is comparatively little reported about the chemical makeup and pharmacological effects of OH. Nevertheless, there has been some research over the past few years that shows promise for the future usage perspectives of OH. To date, 17 compounds were isolated and elucidated, including polyynes, glycosides, lignans, and polyenes, with most of the attention being paid to the polyynes. Gas chromatography (GC) and high-performance liquid chromatography (HPLC) were used to determine the contents of volatile compounds and polyynes in the essential oil and extracts of OH. For the pharmacological studies, antibacterial and antidiabetes effects of polyynes were reported. Our recent study has focused more on the anticancer effects of OH and the involved mechanisms of action. In this review, we will summarize the research status in the botany, phytochemistry, and pharmacology of OH.

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Titel: Chemical and pharmacological studies of Oplopanax horridus, a North American botanical
verfasst von: Tyler Calway
Guang-Jian Du
Chong-Zhi Wang
Wei-Hua Huang
Jing Zhao
Shao-Ping Li
Chun-Su Yuan
Publikationsdatum: 01.04.2012
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2012
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0602-2

Springer Medizin

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